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Nafarelin

Nafarelin Structure
Nafarelin structure
CAS No.
76932-56-4
Chemical Name:
Nafarelin
Synonyms
C07613;Nasanyl;Nacenyl;Synarel;RS-94991;AI314925;Synrelina;NAFARELIN;AI3 14925;AI3-14925
CBNumber:
CB4246893
Molecular Formula:
C66H83N17O13
Molecular Weight:
1322.47
MDL Number:
MFCD00871253
MOL File:
76932-56-4.mol
MSDS File:
SDS
Last updated:2024-03-21 13:23:50
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Nafarelin Properties

Density 1.49±0.1 g/cm3(Predicted)
solubility DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
pka 9.82±0.15(Predicted)
form Solid
color White to Off-White
InChIKey RWHUEXWOYVBUCI-ITQXDASVSA-N
EWG's Food Scores 1
FDA UNII 1X0094V6JV
ATC code H01CA02

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360
HS Code  3504009000

Nafarelin price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 255938 Nafarelin 76932-56-4 1mg $389 2021-12-16 Buy
American Custom Chemicals Corporation API0000035 NAFARELIN 95.00% 76932-56-4 8MG $870.17 2021-12-16 Buy
Biosynth Carbosynth FN65097 Nafarelin acetate 76932-56-4 50mg $263 2021-12-16 Buy
Biosynth Carbosynth FN65097 Nafarelin acetate 76932-56-4 10mg $75 2021-12-16 Buy
AK Scientific K335 Nafarelin acetate salt hydrate 76932-56-4 5mg $112 2021-12-16 Buy
Product number Packaging Price Buy
255938 1mg $389 Buy
API0000035 8MG $870.17 Buy
FN65097 50mg $263 Buy
FN65097 10mg $75 Buy
K335 5mg $112 Buy

Nafarelin Chemical Properties,Uses,Production

Description

Nafarelin is a gonadorelin analogue. It produces an initial phase of stimulation followed by down-regulation of gonadotrophin-releasing hormone receptors, thus reducing the release of FSH and LH, leading to inhibition of androgen and oestrogen production.

Chemical Properties

Nafarelin is a synthetic analogue of gonadotrophin-releasing hormone (GnRH), which is about 200 times more potent than the native hormone and is more resistant to proteolysis Chrisp and Goa (1990), Parker and Schimmer (2001). Like GnRH, it binds with high affinity to the GnRH receptor on anterior pituitary cells, where it acts as an agonist. 

Originator

Nafarelin Acetate,Bachem AG

Uses

LHRH agonist.

brand name

Synarel (Searle).

Therapeutic Function

Gonadotropic

Biological Functions

Acutely, Nafarelin stimulates the secretion of LH and FSH from the anterior pituitary, but prolonged, continuous exposure leads to inhibition of secretion by desensitization of the pituitary gonadotropes Vickery (1985). The initial stimulation of gonadotrophin secretion results in an increase in serum concentrations of estradiol in females and testosterone in males. These then decrease to very low concentrations equivalent to those found in menopausal women and castrated men respectively.

Clinical Use

Nafarelin has potential wide therapeutic applications in the treatment of endometriosis, uterine leiomyoma (fibroids), malignant neoplasms, and in assisted reproduction protocols. However, its use is currently restricted to the treatment of endometriosis and in assisted reproduction protocols.

Side effects

Nafarelin does not have the same androgenic adverse effects as danazol, but it can cause menopausal symptoms. The most commonly reported symptoms are hot flushes, vaginal dryness, altered libido and headaches. Treatment for 6 months results in a loss of bone density. The vertebral trabecular bone density falls by nearly 9% and may not return to normal after treatment. Nafarelin also has a similar effect to oestrogen deficiency on blood lipids e.g. concentrations of total cholesterol and triglycerides may increase.

Synthesis

i. 1 mmol from preparation A was placed in the reaction vessel of a 5 L Vega 296 automatic solid phase peptide synthesizer.
ii. Following amino acids were added to the Preparation A resin:
Nα-Boc-Pro 2 equiv.
Nα-Boc-Arg 2 equiv.
Nα-Boc-Leu 2 equiv.
Nα-Boc-D-NaI 1.5 equiv.
Nα-Boc-Tyr 1.5 quiv
Nα-Boc-Ser(tBu) 2 equiv.
Nα-Boc-Trp 1.75 equiv.
Nα-Boc-His(tos) 1.75 equiv.
(pyro)Glu 2.5 equiv.
iii. Crude peptide was dissolved in 2M acetic acid and converted to acetate salt by passage through a column of AG3-X4A resin.
iv. Acetate was dissolved in minimal amount of methanol.
v. It was then reprecipitated using acetone.
vi. It was then purified using HPLC to get the Nafarelin.

Nafarelin Preparation Products And Raw materials

Raw materials

Ethyl acetamidocyanoacetate Benzhydrylamine COBALT(III) FLUORIDE 1-Boc-Pyrrolidine Boc-3-(2-Naphthyl)-D-alanine
N-[(tert-Butoxy)carbonyl]-L-tryptophan BOC-L-Leucine Hydrogen fluoride BOC-Glycine BOC-L-Proline
1-Hydroxybenzotriazole Dicyclohexylcarbodiimide

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Preparation Products

Nafarelin Suppliers

Global( 197)Suppliers
Supplier Tel Email Country ProdList Advantage
Apextide Co Ltd 		+undefined15700198315 senjie.hou@sinopep.com China 71 58
Cellmano Biotech Limited
0551-65326643 18156095617 info@cellmano.com China 999 58
Shanghai Yunao International Trade Co., Ltd 		+8617621705551 asdf@shanghaihg.cn China 265 58
Henan Tengmao Chemical Technology Co. LTD 		+8615238638457 salesvip2@hntmhg.com China 415 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 951 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10248 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Supplier Advantage
Apextide Co Ltd 		58
Cellmano Biotech Limited
58
Shanghai Yunao International Trade Co., Ltd 		58
Henan Tengmao Chemical Technology Co. LTD 		58
hebei hongtan Biotechnology Co., Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei xin bonus chemical co. LTD 		58

View Lastest Price from Nafarelin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nafarelin pictures 2024-04-22 Nafarelin
76932-56-4
 US $30.00 / box 1box 98% 2000kg hebei hongtan Biotechnology Co., Ltd
Nafarelin pictures 2023-12-09 Nafarelin
76932-56-4
 US $110.00-90.00 / kilogram 1kilogram 99% 10 tons/per week Henan Tengmao Chemical Technology Co. LTD
(D-2-Nal6)-LHRH acetate salt pictures 2023-10-12 (D-2-Nal6)-LHRH acetate salt
76932-56-4
 US $50.00 / g 1g 99% 500t Shanghai Yunao International Trade Co., Ltd
  • Nafarelin pictures
  • Nafarelin
    76932-56-4
  • US $30.00 / box
  • 98%
  • hebei hongtan Biotechnology Co., Ltd
  • Nafarelin pictures
  • Nafarelin
    76932-56-4
  • US $110.00-90.00 / kilogram
  • 99%
  • Henan Tengmao Chemical Technology Co. LTD

Nafarelin Spectrum

Nafarelin(76932-56-4)MS

76932-56-4(Nafarelin)Related Search:

Leuprorelin acetate Glucagon Desmopressin Lypressin Gonadorelin acetate
GLP-1 (7-37) Angiotensin acetate Deslorelin Taspoglutide Lixisenatide
Nafarelin Acetate Nafarelin Gonadorelin Nafarelin Acetate (NAF) PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-NHET
3-(NAPHTHALEN-2-YL)PROPAN-1-AMINE PYR-HIS-TRP-SER-TYR-D-ALA-LEU-ARG-PRO-GLY-NH2 NAFARELIN ACETATE

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(D-2-NAL6)-LHRH NAFARELIN 98.0+% Nafareline C07613 Pyr-His-Trp-Ser-Tyr-D-2-Nal-Leu-Arg-Pro-Gly-NH2 acetate salt Nacenyl Nasanyl RS-94991-298 Synarel Synrelina ala(2-naphthyl)(6)-lhr PYR-HIS-TRP-SER-TYR-D-2-NAL-LEU-ARG-PRO-GLY-NH2 NAFARELIN 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-3-(2-naphtyl)-D-Ala-L-Leu-L-Arg-L-Pro-Gly-NH2 RS-94991 76932-60-0 (Monoacetate (salt)) 86220-42-0 (Acetate (salt), hydrate) Lhrh, Ala(2-naphthyl)(6)- Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)- Nafarelin [inn:ban] Nafarelina Nafarelina [spanish] (D-2-Nal6)-LHRH Nafarelin 6-(3-(2-naphthalenyl)-d-alanine)-luteinizinghormone-releasingfactor(pig 6-(3-(2-naphthalenyl)-d-alanine)luteinizinghormone-releasingfactor(pig) Nafarelin Acetate|(D-2-Nal6)-LHRH Luteinizing hormone-releasing factor (swine), 6-[3-(2-naphthalenyl)-D-alanine]- N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[[(2-amino-2-oxoethyl)amino]-oxomethyl]-1-pyrrolidinyl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(2-naphthalenyl)-1-oxopro Nafarelin, >98% Nafarelin USP/EP/BP (D-2-Nal6)-LHRH acetate salt TIANFU-CHEM_Nafarelin 76932-56-4 99.0% Nafarelin Acetate, Nafarelina AI3 14925 AI314925 AI3-14925 Nafarelin acetate salt 76932-56-4 C66H83N17O13 hormones