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Pentetrazol

CAS No.
54-95-5
Chemical Name:
Pentetrazol
Synonyms
PTZ;pentylenetetrazol;Tetrazol;Pentetrazole;PENTYLENETETRAZOLE;TT87;Su-Zol;Cortis;Corvis;Opticor
CBNumber:
CB4248615
Molecular Formula:
C6H10N4
Molecular Weight:
138.17
MDL Number:
MFCD00005939
MOL File:
54-95-5.mol
MSDS File:
SDS
Last updated:2023-09-06 17:45:48

Pentetrazol Properties

Melting point 59-61 °C (lit.)
Boiling point 194 °C/12 mmHg (lit.)
Density 1.0617 (rough estimate)
refractive index 1.4910 (estimate)
Flash point 194°C/12mm
storage temp. -20°C
solubility ≥15.38 mg/mL in EtOH; ≥6.3 mg/mL in DMSO; ≥83.2 mg/mL in H2O
form solid
pka 1.25±0.20(Predicted)
color White, crystalline powder
Sensitive Hygroscopic
Merck 14,7141
BRN 135492
Stability Stable. Incompatible with strong oxidizing agents.
InChIKey CWRVKFFCRWGWCS-UHFFFAOYSA-N
CAS DataBase Reference 54-95-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII WM5Z385K7T
NIST Chemistry Reference Pentylenetetrazol(54-95-5)
ATC code R07AB03,R07AB53
EPA Substance Registry System Pentetrazol (54-95-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P301+P310+P330-P302+P352-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36/37/38-23/24/25
Safety Statements  26-36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  XF8225000
TSCA  Yes
HazardClass  6.1
PackingGroup  II
Toxicity LD50 in rats (mg/kg): 85±2 s.c., 62 i.p. (Goldenthal)
NFPA 704
1
3 0

Pentetrazol price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P6500 Pentylenetetrazole 54-95-5 25g $98.5 2024-03-01 Buy
Sigma-Aldrich P6500 Pentylenetetrazole 54-95-5 50g $188 2024-03-01 Buy
Alfa Aesar L16185 1,5-Pentamethylene-1H-tetrazole, 98% 54-95-5 5g $29.65 2024-03-01 Buy
Alfa Aesar L16185 1,5-Pentamethylene-1H-tetrazole, 98% 54-95-5 25g $90.7 2024-03-01 Buy
Cayman Chemical 18682 Pentylenetetrazole ≥98% 54-95-5 10g $44 2024-03-01 Buy
Product number Packaging Price Buy
P6500 25g $98.5 Buy
P6500 50g $188 Buy
L16185 5g $29.65 Buy
L16185 25g $90.7 Buy
18682 10g $44 Buy

Pentetrazol Chemical Properties,Uses,Production

Description

Pentylenetetrazole (PTZ) is a central nervous system modulator that is used to experimentally induce seizures in animals. Subcutaneous PTZ has been used extensively to screen for compounds that block the production of nonconvulsive (absence or myoclonic) seizures. PTZ has diverse, site-specific effects in the brain. However, it is an antagonist of GABAA receptors and some drugs that block PTZ-induced seizures, including benzodiazepines, act at the GABAA receptor.

Chemical Properties

white crystalline powder

Originator

Pentylenetetrazole,Spectrum Chemicals and

Uses

Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.

Uses

analeptic, circulation stimulant

Uses

Non-specific CNS stimulant; convulsant; narcotic antagonist.

Definition

ChEBI: An organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other espiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.

Manufacturing Process

A solution of 9.8 g cyclohexanone and 8.6 g HNO3 in about 250 ml benzene were slowly added dropwise to 20 ml concentrate sulfuric acid in 100 ml benzene by ice cooling and stirring. After ending of a generation of N2 (0.1 moles) to a corresponding quantity of cyclohexane (0.1 moles). Acid layer was diluted with ice, and made neutral with strong alkaline to give a reaction product as oil. Then it was exrtacted with chloroform, all solvents were distilled and the residue was diluted with water. The desired 6,7,8,9tetrahydro-5H-tetrazoloazepine dropped. Yield was 7.5 g after recrystallization from ester or distillation. M.P: 65°C.

brand name

Cardiazol (Knoll).

Therapeutic Function

Analeptic, Central stimulant

General Description

White crystalline powder or granular solid with a slightly pungent odor. Bitter taste. Aqueous solutions neutral to litmus.

Air & Water Reactions

Dust can be explosive when suspended in air at specific concentrations. Water soluble.

Reactivity Profile

Pentetrazol is incompatible with oxidizing agents. . Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. Azo dyes can be explosive when suspended in air at specific concentrations.

Fire Hazard

Flash point data for Pentetrazol are not available. Pentetrazol is probably combustible.

Biological Activity

CNS stimulant that induces kindling in vivo . Causes alterations in excitatory and inhibitory neurotransmitter systems.

Biochem/physiol Actions

Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.

Safety Profile

A human poison by ingestion and intravenous routes. Poison experimentally by ingestion, intravenous, intraperitoneal, subcutaneous, rectal, and parenteral routes. When heated to decomposition it emits toxic fumes of NOx.

storage

-20°C

Purification Methods

pKEst Crystallise metrazol from diethyl ether and dry it under vacuum over P2O5, or distil it. [Schmidt Chem Ber 57 704 1924, Beilstein 26 II 213.]

Pentetrazol Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 128)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd.
+8617531190177 peter@yan-xi.com China 5990 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58
Xi'an MC Biotech, Co., Ltd.
029-89275612 +8618991951683 mcbio_sales@163.com China 2255 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33349 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32360 55

View Lastest Price from Pentetrazol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
pentetrazol pictures 2023-09-06 pentetrazol
54-95-5
US $50.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
	Pentetrazol pictures 2020-01-05 Pentetrazol
54-95-5
US $1.00 / KG 1KG 95-99% 1ton Career Henan Chemical Co
  • pentetrazol pictures
  • pentetrazol
    54-95-5
  • US $50.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • 	Pentetrazol pictures
  • Pentetrazol
    54-95-5
  • US $1.00 / KG
  • 95-99%
  • Career Henan Chemical Co
Leptazole Metalex-P Metrazol Nauranzol Naurazol Nedcardol Neocardol Neurazol Novo cora-vinco novocora-vinco Opticor Pemetesan Penetiazol Penetrasol Penetratsol Pentacard Pentacor Pentamethazol Pentamethazolum Pentamethylene-1,5-tetrazole Pentamethylenetetrazol 5-a)azepine,6,7,8,9-tetrahydro-5h-tetrazolo( 5-a]azepine,6,7,8,9-tetrahydro-5h-tetrazolo[ 5H-Tetrazolo[1,5-a]azepine, 6,7,8,9-tetrahydro- 5H-Tetrazoloazepine, 6,7,8,9-tetrahydro- 6,7,8,9-Tetrahydro-5-azepotetrazole 6,7,8,9-Tetrahydro-5H-tetraazolo[1,5-a]azepine 6,7,8,9-tetrahydro-5h-tetrazoloazepin 7,8,9,10-tetrazabicyclo(5.3.0)-8,10-decadiene 7,8,9,10-Tetrazabicyclo[5.3.0]deca-8,10-diene Angiazol Angioton Angiotonin Cardiazol Cardifortan Cardiol Cardiotonicum Cardosal Cardosan Cenalene-M Cenazol Centrazole Cerebro-nicin Coranormal Coranormol Corasol Coratoline Corazol Corazole Corazole (analeptic) pentamethylene-tetrazol Pentametilentetrazolo Pentazol Pentazolum Pentemesan Pentetrazol Pentrazol Pentrolone