nimotuzumab
- CAS No.
- 828933-51-3
- Chemical Name:
- nimotuzumab
- Synonyms
- nimotuzumab;Research Grade Nimotuzumab(DHB86914)
- CBNumber:
- CB42498825
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| NCI Dictionary of Cancer Terms | nimotuzumab |
|---|---|
| FDA UNII | 6NS400BXKH |
| NCI Drug Dictionary | nimotuzumab |
nimotuzumab Chemical Properties,Uses,Production
Description
Overexpression of epidermal growth factor receptor (EGFR), a transmembrane receptor tyrosine kinase, is prevalent in malignant tumors of epithelial origin and is especially common in breast, head and neck, colon, and lung cancer. With EGFR overexpression, prognosis is poor due to associated tumor invasion, metastasis, enhanced angiogenesis, and resistance to chemotherapy; thus, modulation of EGFR-mediated signaling is an attractive target for intervention. Small-molecule kinase inhibitors (gefitinib and erlotinib) and a monoclonal antibody (cetuximab) specific for EGFR are in clinical evaluation, but treatment cessation due to development of severe acne-like rash is common with these EGFR antagonists. Notably, nimotuzumab, a humanized form of the murine IgG2a monoclonal antibody that has been launched in India for treatment of head and neck cancers overexpressing EGFR, demonstrates clinical efficacy devoid of the rash toxicity. .
Originator
Center for Molecular Immunology (Cuba)
brand name
BioMab EFGR, Theraloc
nimotuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8012 | 62 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 15926423062 | 422450190@qq.com | China | 10132 | 58 |
| Abmole Bioscience Inc. | 021-50967598 02150967598 | sales@abmole.cn | China | 4495 | 58 |
| Jiangxi ravel Biotechnology Co.,Ltd | 13184580281 | hj@ruiweier.cn | China | 2102 | 58 |
| Hubei Kele Fine Chemical Co., Ltd | 027-59101668 19945030958 | 2881924765@qq.com | China | 7977 | 58 |