Piperazine citrate
- CAS No.
- 144-29-6
- Chemical Name:
- Piperazine citrate
- Synonyms
- ANTEPAR;Pinozan;PARAZINE;Patazine;Piperasol;Citraazine;Coliurinal;PIPERAZINE CITRATE;PiperazineCitrateBp;Tripiperazindicitrat
- CBNumber:
- CB4258805
- Molecular Formula:
- C24H46N6O14
- Molecular Weight:
- 642.65
- MDL Number:
- MFCD00038961
- MOL File:
- 144-29-6.mol
- MSDS File:
- SDS
| Melting point | 183-187℃ |
|---|---|
| Boiling point | 208℃[at 101 325 Pa] |
| Density | 0.741[at 20℃] |
| vapor pressure | 56.928Pa |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in DMSO |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | 54g/L at 24℃ |
| Merck | 14,7464 |
| LogP | -1.15 |
| CAS DataBase Reference | 144-29-6(CAS DataBase Reference) |
| FDA UNII | RI85381D5G |
| EPA Substance Registry System | Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2) (144-29-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H317-H314-H319 | |||||||||
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | TL3485000 | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
Piperazine citrate price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P2000000 | Piperazine citrate European Pharmacopoeia (EP) Reference Standard | 144-29-6 | P2000000 | $150 | 2024-03-01 | Buy |
| TCI Chemical | P0449 | Piperazine Citrate Hydrate >98.0%(T) | 144-29-6 | 25g | $31 | 2024-03-01 | Buy |
| TCI Chemical | P0449 | Piperazine Citrate Hydrate >98.0%(T) | 144-29-6 | 500g | $71 | 2024-03-01 | Buy |
| TRC | P479890 | Piperazine citrate | 144-29-6 | 25g | $140 | 2021-12-16 | Buy |
| TRC | P479890 | Piperazine citrate | 144-29-6 | 100g | $275 | 2021-12-16 | Buy |
Piperazine citrate Chemical Properties,Uses,Production
Description
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.
Chemical Properties
Piperazine citrate is a white, crystalline powder, with not more than a slight odor. It is soluble in water, and insoluble in alcohol and in ether.
Uses
Piperazine Citrate is an anthelmintic agent used in the treatment of parasitic infections. Also used in the reduction of blood pressure.
Indications
Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
brand name
Antepar (GlaxoSmithKline); Bryrel (Sanofi Aventis).
Flammability and Explosibility
Not classified
Mechanism of action
Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
Pharmacokinetics
Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.
Piperazine citrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Masteam Bio-tech Co., Ltd. | +86-15200345168 +86-15200345168 | bruce.lei@masteam.com | CHINA | 153 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 893 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 724 | 55 | |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
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View Lastest Price from Piperazine citrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | Piperazine Citrate
144-29-6
|
US $0.00 / kg | 1kg | 99% | 10000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | |
 |
2024-03-31 | Piperazine citrate
144-29-6
|
US $30.00-10.00 / BOX | 10BOX | 99 | 20TONS | Shanghai Chinqesen Biotechnology Co., Ltd. | |
 |
2023-09-07 | PIPERAZINE CITRATE
144-29-6
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- Piperazine Citrate
144-29-6
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Piperazine citrate
144-29-6
- US $30.00-10.00 / BOX
- 99
- Shanghai Chinqesen Biotechnology Co., Ltd.
-
- PIPERAZINE CITRATE
144-29-6
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd