Nutlin-3b
- CAS No.
- 675576-97-3
- Chemical Name:
- Nutlin-3b
- Synonyms
- CS-986;Nutlin-3b;9-trioxaundecane;11-Bis(tosyloxy)-3;NUTLIN-3B;NUTLIN 3B;Nutlin-3b USP/EP/BP;(+)-NUTLIN-3;NUTLIN 3B;Nutlin-3b - Nutlin-3, (+)-;4-[[(4R,5S)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imid;4-((4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-2-one
- CBNumber:
- CB42624268
- Molecular Formula:
- C30H30Cl2N4O4
- Molecular Weight:
- 581.49
- MDL Number:
- MFCD11977784
- MOL File:
- 675576-97-3.mol
- MSDS File:
- SDS
| Density | 1.36 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥55.5 mg/mL in EtOH; ≥57.25 mg/mL in DMSO |
| form | crystalline solid |
| pka | 14.35±0.20(Predicted) |
| FDA UNII | FJA1772CVW |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H410-H372 |
| Precautionary statements | P260-P264-P273-P501 |
Nutlin-3b price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10009816 | (+)-Nutlin-3 ≥98% | 675576-97-3 | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 10009816 | (+)-Nutlin-3 ≥98% | 675576-97-3 | 5mg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 10009816 | (+)-Nutlin-3 ≥98% | 675576-97-3 | 10mg | $245 | 2024-03-01 | Buy |
| Cayman Chemical | 10009816 | (+)-Nutlin-3 ≥98% | 675576-97-3 | 25mg | $536 | 2024-03-01 | Buy |
| TRC | N925530 | Nutlin3b | 675576-97-3 | 10mg | $250 | 2021-12-16 | Buy |
Nutlin-3b Chemical Properties,Uses,Production
Description
(+)-Nutlin-3 is the enantiomer and less active form of the p53-Mdm2 protein-protein interaction inhibitor (–)-nutlin-3 . It inhibits the interaction between p53 and Mdm2 150-fold less potently than (–)-nutlin-3 with an IC50 value of 13.6 μM. (+)-Nutlin-3 has been used as a negative control for the p53-modulating activity of (–)-nutlin-3 in cancer cells.
Uses
Nutlin 3b is a small molecule MDM2 antagonist.
Definition
ChEBI: Nutlin-3 is a Nutlin and a piperazinone. It has a role as an anticoronaviral agent.
References
[1] tovar c, rosinski j, filipovic z, higgins b, kolinsky k, hilton h, zhao x, vu bt, qing w, packman k, myklebost o, heimbrook dc, vassilev lt. small-molecule mdm2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. proc natl acad sci u s a. 2006 feb 7;103(6):1888-93.
[2] cao c, shinohara et, subhawong tk, geng l, kim kw, albert jm, hallahan de, lu b. radiosensitization of lung cancer by nutlin, an inhibitor of murine double minute 2. mol cancer ther. 2006 feb;5(2):411-7.
Nutlin-3b Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28761 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
