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AGI6780

AGI6780 structure

CAS No.: 1432660-47-3

Chemical Name:: AGI6780

Synonyms: CS-1905;CS-1019;AGI6780;AGI-6780, >=98%;AGI6780 USP/EP/BP;AGI-6780, that potently and selectively inhibits the tumor-associated mutant IDH2R140Q;N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoroMethyl)phenyl)ureido)benzenesulfonaMide;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide;Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide AGI-6780

CBNumber:: CB42652324

Molecular Formula:: C21H18F3N3O3S2

Molecular Weight:: 481.51

MDL Number:: MFCD26097285

MOL File:: 1432660-47-3.mol

Last updated:2023-05-21 10:59:17

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AGI6780 Properties

Density	1.52±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥22.25 mg/mL in DMSO; insoluble in H2O; ≥100.8 mg/mL in EtOH
form	solid
pka	11.78±0.20(Predicted)

SAFETY

Risk and Safety Statements

HS Code	2935909099

AGI6780 price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0895	AGI-6780 ≥98% (HPLC)	1432660-47-3	5MG	$150	2024-03-01	Buy
Sigma-Aldrich	SML0895	AGI-6780 ≥98% (HPLC)	1432660-47-3	25MG	$598	2024-03-01	Buy
Sigma-Aldrich	5.09880	IDH2 Inhibitor, R140Q Somatic Mutant-Specific, AGI-6780 - CAS 1432660-47-3 - Calbiochem	1432660-47-3	10mg	$265	2024-03-01	Buy
Cayman Chemical	14639	AGI-6780 ≥98%	1432660-47-3	1mg	$44	2024-03-01	Buy
Cayman Chemical	14639	AGI-6780 ≥98%	1432660-47-3	5mg	$112	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0895	5MG	$150	Buy
SML0895	25MG	$598	Buy
5.09880	10mg	$265	Buy
14639	1mg	$44	Buy
14639	5mg	$112	Buy

AGI6780 Chemical Properties,Uses,Production

Description

AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant with IC50 of 23 nM.

In vitro

AGI-6780 potently reduce (R)-2-hydroxyglutarate (2HG) levels in cell lines ectopically overexpressing IDH2/R140Q with EC50 of 20 nM, with excellent selectivity against other dehydrogenases. AGI-6780 reverses the IDH2/R140Q-induced differentiation block in TF-1 cells, and induces blast differentiation in primary human IDH2/R140Q AML patient samples.

Uses

AGI-6780 is a small molecule inhibitor of the tumor associated mutant IDH2 (Isocitrate Dehydrogenase-2) in leukemia cells. This compound is suitable for IDH (isocitrate dehydrogenase) related research.

Biological Activity

agi-6780 is a potent and selective inhibitor of tumor-associated idh2/r140q mutation with ic50 value of 23 nm [1].agi-6780 could significantly reduce intracellular concentration of 2hg in the human glioblastoma tf1/r140q cells, as well as reverse idh2/r140q-mediated differentiation block in tf1 cells in the presence of epo. agi-6780 could restore klf1 and hemoglobin g1/2 expressions in the epo-induced tf1/r140q cells [1].

target

IDH2-R140Q

References

[1] wang f1, travins j, delabarre b, penard-lacronique v, schalm s, hansen e, straley k, kernytsky a, liu w, gliser c, yang h, gross s, artin e, saada v,mylonas e, quivoron c, popovici-muller j, saunders jo, salituro fg, yan s, murray s, wei w, gao y, dang l, dorsch m, agresta s, schenkein dp, biller sa, su sm, de botton s, yen ke. targeted inhibition of mutant idh2 in leukemia cells induces cellular differentiation. science. 2013 may 3;340(6132):622-6.

AGI6780 Preparation Products And Raw materials

Raw materials

Preparation Products

AGI6780 Suppliers

Global( 108)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3842	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29576	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from AGI6780 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-20	AGI6780 1432660-47-3	US $0.00-0.00 / KG	5g	99% HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	AGI6780 1432660-47-3	US $1.00 / KG	1G	98%	100KG	Career Henan Chemical Co

AGI6780
1432660-47-3
US $0.00-0.00 / KG
99% HPLC
Shaanxi Dideu Medichem Co. Ltd

AGI6780
1432660-47-3
US $1.00 / KG
98%
Career Henan Chemical Co

AGI6780 Spectrum

AGI6780(1432660-47-3)¹HNMR

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AGI6780 AGI-6780, >=98% N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoroMethyl)phenyl)ureido)benzenesulfonaMide N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]- AGI-6780 N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide N-Cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-benzenesulfonamide AGI-6780 CS-1019 CS-1905 AGI6780 USP/EP/BP AGI-6780, that potently and selectively inhibits the tumor-associated mutant IDH2R140Q 1432660-47-3 C21H18F3N3O3S2 Inhibitors API