PTP Inhibitor V, PHPS1
- CAS No.
- 314291-83-3
- Chemical Name:
- PTP Inhibitor V, PHPS1
- Synonyms
- PHPS1;PHPS1 sodium salt;PTP Inhibitor V, PHPS1;PHPS1 sodium salt hydrate;PTP Inhibitor V, PHPS1 - CAS 314291-83-3 - Calbiochem;4-(2-(3-(4-Nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)hydrazinyl)benzenesulfonic acid;Benzenesulfonic acid, 4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-;atherosclerosis,kidney,Erk1/2,inhibit,PTP1B,prostate,Shp1,PHPS1,colon,Phosphatase,lung,Shp2,carcinoma,cancer,Inhibitor;4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid sodium salt hydrate
- CBNumber:
- CB42685465
- Molecular Formula:
- C21H15N5O6S
- Molecular Weight:
- 465.44
- MDL Number:
- MFCD01079012
- MOL File:
- 314291-83-3.mol
- MSDS File:
- SDS
| Density | 1.54±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear (warmed) |
| pka | -2.90±0.40(Predicted) |
| form | solid |
| color | red |
| InChI | InChI=1S/C21H15N5O6S/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16/h1-13,22H,(H,30,31,32) |
| InChIKey | VIQSBJOMLQLAKC-UHFFFAOYSA-N |
| SMILES | C1(S(O)(=O)=O)=CC=C(NN=C2C(=O)N(C3=CC=CC=C3)N=C2C2=CC=C([N+]([O-])=O)C=C2)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| WGK Germany | 2 |
PTP Inhibitor V, PHPS1 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0039 | PHPS1 sodium salt hydrate ≥98% (HPLC) | 314291-83-3 | 5mg | $211 | 2024-03-01 | Buy |
| Sigma-Aldrich | 540213 | PTP Inhibitor V, PHPS1 | 314291-83-3 | 10mg | $187 | 2024-03-01 | Buy |
| Cayman Chemical | 18856 | PHPS1 ≥98% | 314291-83-3 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 18856 | PHPS1 ≥98% | 314291-83-3 | 5mg | $129 | 2024-03-01 | Buy |
| Sigma-Aldrich | P0039 | PHPS1 sodium salt hydrate ≥98% (HPLC) | 314291-83-3 | 25mg | $735 | 2022-05-15 | Buy |
PTP Inhibitor V, PHPS1 Chemical Properties,Uses,Production
Description
PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of SH-PTP2 (Shp-2) (IC50 and Ki = 2.1 and 0.73μM, respectively). PHPS1 inhibits PCPTP1 (ECPTP), PTP1B, SH-PTP1 (Shp1), mycobacterium MptpA only at higher concentrations (IC50 ;= 5.4, 19, 30, and 39 μM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 μM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation
Uses
Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) sodium salt hydrate has been used as a protein-tyrosine phosphatase (shp2) inhibitor to study its effects on bisphenol A (BPA) and nonyl phenol (NP)-induced cell proliferation of MCF7 cell. It has also been used as a shp2 inhibitor to study its pro-atherosclerotic or atheroprotective effect in vivo and in vitro.
Biochem/physiol Actions
Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) represses E2-induced gene transcription and rapid DNA synthesis. It also blocks mitogen-activated protein kinase (ERK1/2) activation and reduces the cigarette smoke induced-inflammatory response in mouse lungs.
PTP Inhibitor V, PHPS1 Preparation Products And Raw materials
Raw materials
Preparation Products
PTP Inhibitor V, PHPS1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12803 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4664 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |