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m-Toluidine

CAS No.
108-44-1
Chemical Name:
m-Toluidine
Synonyms
META TOLUIDINE;m-Toluidin;3-METHYLALANINE;3-METHYLANILINE;3-Toluidine;3-AMINOTOLUENE;m-Aminotoluene;m-Methylaniline;1-Amino-3-methylbenzene;m-Toludine
CBNumber:
CB4277541
Molecular Formula:
C7H9N
Molecular Weight:
107.15
MDL Number:
MFCD00007808
MOL File:
108-44-1.mol
MSDS File:
SDS
Last updated:2024-01-25 16:49:23

m-Toluidine Properties

Melting point -30 °C
Boiling point 203-204 °C(lit.)
Density 0.999 g/mL at 25 °C(lit.)
vapor pressure 0.3 hPa (20 °C)
refractive index n20/D 1.567(lit.)
Flash point 186 °F
storage temp. Store below +30°C.
solubility 0.2 g/100 mL (20°C)
pka 4.73(at 25℃)
form Crystalline Solid or Liquid
color White
PH 7 (H2O, 20℃)
Odor aromatic aniline-like odor
Viscosity 0.39mm2/s
Water Solubility 0.2 g/100 mL (20 ºC)
Merck 14,9536
BRN 635944
Exposure limits TLV-TWA skin 2-ppm (~9 mg/m3) (ACGIH).
Dielectric constant 5.9500000000000002
InChIKey JJYPMNFTHPTTDI-UHFFFAOYSA-N
LogP 1.4 at 25℃
CAS DataBase Reference 108-44-1(CAS DataBase Reference)
EWG's Food Scores 2
FDA UNII 006FKQ96T3
NIST Chemistry Reference Benzenamine, 3-methyl-(108-44-1)
EPA Substance Registry System m-Toluidine (108-44-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H311+H331-H317-H373-H410
Precautionary statements  P273-P280-P301+P310-P302+P352+P312-P304+P340+P311-P314
Hazard Codes  T,N
Risk Statements  45-23/24/25-33-50
Safety Statements  53-28-36/37-45-61-28A
RIDADR  UN 1708 6.1/PG 2
WGK Germany  2
RTECS  XU2800000
8-23
Autoignition Temperature >500 °C
Hazard Note  Toxic
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29171990
HS Code  29214300
NFPA 704
2
4 0

m-Toluidine price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.08314 m-Toluidine for synthesis 108-44-1 100mL $36.9 2024-03-01 Buy
Sigma-Aldrich 8.08314 m-Toluidine for synthesis 108-44-1 1L $95.6 2024-03-01 Buy
Sigma-Aldrich 511218 m-Toluidine 99% 108-44-1 5ml $31.14 2024-03-01 Buy
Sigma-Aldrich 511218 m-Toluidine 99% 108-44-1 1l $159 2024-03-01 Buy
TCI Chemical T0298 m-Toluidine >98.0%(GC)(T) 108-44-1 25mL $22 2024-03-01 Buy
Product number Packaging Price Buy
8.08314 100mL $36.9 Buy
8.08314 1L $95.6 Buy
511218 5ml $31.14 Buy
511218 1l $159 Buy
T0298 25mL $22 Buy

m-Toluidine Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid. Slightly soluble in water; soluble in alcohol or ether. Combustible.

Uses

m-Toluidine is an intermediate in the manu facture of dyes and other chemicals.

Uses

Dyes, manufacture of organic chemicals.

Uses

m-Toluidine is used in the manufacture of organic chemicals. It is also used in manufacture of various dyes and pigments, photo chemicals, pharmaceutical intermediates.antioxidants, curing agent, accelerator for polymer and rubber industry.

Synthesis Reference(s)

Synthetic Communications, 11, p. 925, 1981 DOI: 10.1080/00397918108065749

General Description

A clear colorless liquid. Flash point below 200°F. Vapors heavier than air. Toxic by inhalation, ingestion, and skin absorption in high concentrations or under prolonged exposures. Used in the manufacture of organic chemicals. Density about 8 lb / gal.

Reactivity Profile

m-Toluidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Can react vigorously with oxidizing reagents. Emits toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1253].

Health Hazard

Absorption of toxic quantities by any route causes cyanosis (blue discoloroation of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation.

Health Hazard

The toxicity of m-toluidine is similar to thatof o-toluidine. The exposure routes are ingestion, inhalation, and absorption through skin.The toxic effects are methemoglobinemia,anemia, and hematuria. It metabolizes to 2-amino-4-methylphenol, the major componentexcreted in urine. Inhalation of 40-ppm concentration for an hour produced severe poi soning in humans. The oral LD50 value inmice is 740 mg/kg, which is in a range com parable to its o- and p-isomers.
The pure liquid is a mild to moderate skinirritant. Its irritating effect on the eyes ofrabbits was strong.
m-Toluidine did not induce any carcino genicity in test subjects. This finding is incontrast to its ortho-isomer. Nor did it produce any mutagenic activity.

Fire Hazard

Special Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire.

Flammability and Explosibility

Non flammable

Safety Profile

Poison by ingestion and intraperitoneal routes, A skin and eye irritant. Flammable when exposed to heat or flame. Can react vigorously on contact with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx. See also ANILINE and o-TOLUIDINE.

Carcinogenicity

In an 18-month carcinogenicity diet evaluation in maleCD rats (8000 ppm for 3 months, and then 4000 ppm for additional 15 months; or 16,000 ppm for 3 months, and then 8000 for additional 15 months), and male and female CD-1 mice (16,000 ppm for 5 months, and then 4000 ppm in males and 8000 ppm in females for additional 13 months; or 32,000 ppm in both sexes for 5 months, and then 8000 ppm in males and 16,000 ppm in females for additional 13 months), there was no evidence of a significant increase of incidence of any kind of tumor in the rats, and only a significant increase in liver tumors in male mice.

Purification Methods

It can be purified as for aniline. Twice-distilled, m-toluidine is converted to the hydrochloride using a slight excess of HCl, and the salt is fractionally crystallised from 25% EtOH (five times), and from distilled water (twice), rejecting, in each case, the first material that crystallised out. The amine is regenerated and distilled as for o-toluidine. The benzoyl derivative has m 125o (from EtOH). [Berliner & May J Am Chem Soc 49 1007 1927, Beilstein 12 H 853, 12 I 397, 12 II 463, 12 III 1949, 12 IV 1813.]

625-95-6
108-44-1
Synthesis of m-Toluidine from 3-Iodotoluene
Global( 413)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Xin Cheng Yue Chemical Co.,Ltd
+86-021-57806787 +86-17701820076 wuziwei@xinyuefirm.com China 30 58
Changde Changlian Chemical Co., Ltd.
+86-25-86736270 +86-15905172087 brian.he@royal-chem.com China 103 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Henan Fengda Chemical Co., Ltd
+8613613820652 info@fdachem.com China 4685 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14770 58
Henan Tianfu Chemical Co.,Ltd.
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Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Anhui Royal Chemical Co., Ltd.
+86-25-86655873 +8613962173137 marketing@royal-chem.com China 535 55

View Lastest Price from m-Toluidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
m-Toluidine pictures 2024-03-19 m-Toluidine
108-44-1
US $5.00 / kg 1kg ≥98% 200mt/year Jinan Finer Chemical Co., Ltd
m-Toluidine pictures 2024-02-24 m-Toluidine
108-44-1
US $0.00 / kg 10000kg 99.8% 100000ton Shanghai Xin Cheng Yue Chemical Co.,Ltd
m-Toluidine pictures 2023-12-23 m-Toluidine
108-44-1
US $50.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
  • m-Toluidine pictures
  • m-Toluidine
    108-44-1
  • US $5.00 / kg
  • ≥98%
  • Jinan Finer Chemical Co., Ltd
  • m-Toluidine pictures
  • m-Toluidine
    108-44-1
  • US $0.00 / kg
  • 99.8%
  • Shanghai Xin Cheng Yue Chemical Co.,Ltd
  • m-Toluidine pictures
  • m-Toluidine
    108-44-1
  • US $50.00-1.00 / KG
  • 99%
  • Henan Fengda Chemical Co., Ltd
M-Toluidine, 99% 5ML M-TOLUIDINE FOR SYNTHESIS 100 ML M-TOLUIDINE FOR SYNTHESIS 1 L Between toluidine M-Toluidine 0 AKOS BBS-00003559 3-METHYLBENZENAMINE 3-AMINO-1-METHYLBENZENE benzeneamine,3-methyl- m-Methylbenzenamine m-toluidin(czech) m-Toluidiue m-toluidyna 3-methylanline m-Toludine M-TOLUIDINE OEKANAL, 250 MG M-ToluidineForSynthesis M-Toluidine>98% m-Tolylamine M-TOLUIDINE m-Toluamine 3-Aminophenylmethane 3-Aminotoluen 3-aminotoluen(czech) 3-methyl-anilin 3-methyl-benzenamin Aniline, 3-methyl- aniline,3-methyl- Benzenamine,3-methyl- META-AMINOTOLUENE M-Toluidine, 99% 1LT m-toluidine 3-aminotoluene THALLIUM MERCURIC NITRATE m-Toluidine ,99% m-Toluidine / MT m-TOLUIDINE, 99%m-TOLUIDINE, 99%m-TOLUIDINE, 99% m-ToluidineSolution,2000mg/L,1ml m-Toluidine > m-Toluidine, GR 99%+ m-Toluidine extrapure, 99% 3-METHYLALANINE 3-METHYLANILINE 3-AMINOTOLUENE m-Aminotoluene m-Toluidin 3-Toluidine META TOLUIDINE m-Methylaniline 1-Amino-3-methylbenzene 13C6]-m-Toluidine Prilocaine Impurity 29 108-44-1 C7H9N1 108441 CH3C6H4NH2 Building Blocks Analytical Reagents Analytical Chromatography Product Catalog