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Chenodeoxycholic acid

Chenodeoxycholic acid
Chenodeoxycholic acid
CAS No.
474-25-9
Chemical Name:
Chenodeoxycholic acid
Synonyms
CDCA;Chenix;chendol;Fluibil;Kebilis;Chenocol;Chenodex;Hekbilin;Ulmenide;Chendiol
CBNumber:
CB4285737
Molecular Formula:
C24H40O4
Formula Weight:
392.57
MOL File:
474-25-9.mol

Chenodeoxycholic acid Properties

Melting point:
165-167 °C(lit.)
alpha 
12 º (c=1, CHCl3)
Flash point:
9℃
storage temp. 
Refrigerator
solubility 
PRACTICALLY INSOLUBLE
form 
Powder
color 
White to off-white
Water Solubility 
PRACTICALLY INSOLUBLE
Merck 
13,2062
InChIKey
RUDATBOHQWOJDD-BSWAIDMHSA-N
CAS DataBase Reference
474-25-9(CAS DataBase Reference)
EPA Substance Registry System
Cholan-24-oic acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.alpha.)- (474-25-9)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  63
Safety Statements  22-24/25-45-36/37
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  FZ1980000
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Chenodeoxycholic acid price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C-145 Chenodeoxycholic acid 500μg/mL in methanol, certified reference material 474-25-9 145-1ml $69 2017-11-08 Buy
Sigma-Aldrich C1050000 Chenodeoxycholic acid European Pharmacopoeia (EP) Reference Standard 474-25-9 1EA $168 2017-11-08 Buy
Alfa Aesar J60364 Chenodeoxycholic acid 474-25-9 25g $222 2017-11-08 Buy
Alfa Aesar J60364 Chenodeoxycholic acid 474-25-9 5g $72.9 2017-11-08 Buy
Sigma-Aldrich C9377 Chenodeoxycholic acid anionic 474-25-9 5g $128 2017-11-08 Buy

Chenodeoxycholic acid Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Chenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase C signaling pathways.It is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion.Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.
  1. Chenodeoxycholic acid is widely utilized in therapeutic applications. It is applied in medical therapy to dissolve gallstones. It is employed in the treatment of cerebrotendineous xanthomatosis. It is used to treat constipation and cerebrotendineous xanthomatosis. It acts as a urea receptor in supramolecular chemistry which can contain anions. It is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells.
  2. Chenodeoxycholic Acid is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for Dye Solar Cells. This co-adsorbent will prevent dye aggregation on the semiconductor surface, reducing losses in the solar cell's operation.
  3. Chenodeoxycholic Acid is a white solid added with the dye powder to the solvent while preparing staining solutions. The concentration of co-adsorbent is typically 10 fold the dye concentration.
  4. Chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX).
  5. It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies.
  6. Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism.EC50 concentrations for activation of FXR range from 13-34 μM.In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometry of 1:2.CDCA toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess CDCA contributes to liver and intestinal cancers.

Uses

anticholithogenic, antilipemic agent

Uses

A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus fa cilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.

Uses

An apoptosis inducer via PKC-dependent signalling pathway.

Chenodeoxycholic acid Preparation Products And Raw materials

Raw materials

Preparation Products


Chenodeoxycholic acid Suppliers

Global( 324)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangsu Zhongbang Pharmaceutical Co., Ltd.
025-87151996
025-87151996 zbsales@chinaredsun.com CHINA 32 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 660 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 300 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20809 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32766 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 2952 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales1@fine-chemtech.com CHINA 895 55
Shanghai LanRun Chemical Co., Ltd. 021-69515658 ; 69515628
021-69515998 longrunchem@163.com China 5966 50

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