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N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide Structure
N,N'-Diisopropylcarbodiimide structure
CAS No.
693-13-0
Chemical Name:
N,N'-Diisopropylcarbodiimide
Synonyms
DIC;Diisopropylcarbodiimide;DIPC;DIPCI;DIPCDI;N,N-DIISOPROPYLCARBODIIMIDE;PCI;DICI;1,3-DIISOPROPYLCARBODIIMIDE;Diisopropylcarbodiimide solution
CBNumber:
CB4301572
Molecular Formula:
C7H14N2
Molecular Weight:
126.2
MDL Number:
MFCD00065689
MOL File:
693-13-0.mol
MSDS File:
SDS
Last updated:2024-03-26 14:13:49
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N,N'-Diisopropylcarbodiimide Properties

Melting point 210-2120C (dec)
Boiling point 145-148 °C(lit.)
Density 0.815 g/mL at 20 °C(lit.)
vapor pressure 34.9hPa at 55.46℃
refractive index n20/D 1.433(lit.)
Flash point 93 °F
storage temp. Store below +30°C.
solubility Soluble in chloroform, methylene chloride, acetonitrile, dioxane, dimethylformamide andtetrahydrofuran.
form Liquid
color Clear colorless to yellow
Sensitive Moisture Sensitive
BRN 878281
Stability Volatile
InChIKey BDNKZNFMNDZQMI-UHFFFAOYSA-N
LogP 4.11 at 20℃
CAS DataBase Reference 693-13-0(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII OQO20I6TWH
NIST Chemistry Reference 2-Propanamine, N,N'-methanetetraylbis-(693-13-0)
EPA Substance Registry System 2-Propanamine, N,N'-methanetetraylbis- (693-13-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H226-H317-H318-H330-H334
Precautionary statements  P210-P233-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T+,T,F,Xn
Risk Statements  10-26-36/37/38-41-42/43-37/38
Safety Statements  26-36/37/39-45-38-28A-16-22
RIDADR  UN 2929 6.1/PG 1
WGK Germany  3
RTECS  FF2175000
F  10-21
Hazard Note  Flammable/Highly Toxic/
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29252000
NFPA 704
2
4 1

N,N'-Diisopropylcarbodiimide price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.03649 N,N′-Diisopropylcarbodiimide for synthesis 693-13-0 10ml $51.3 2024-03-01 Buy
Sigma-Aldrich 8.03649 N,N′-Diisopropylcarbodiimide for synthesis 693-13-0 25mL $99.5 2024-03-01 Buy
Sigma-Aldrich 8.03649 N,N′-Diisopropylcarbodiimide for synthesis 693-13-0 100mL $261 2024-03-01 Buy
Sigma-Aldrich 8.03649 N,N′-Diisopropylcarbodiimide for synthesis 693-13-0 1L $1170 2024-03-01 Buy
Sigma-Aldrich 38370 DIC purum, ≥98.0% (GC) 693-13-0 25ml $89.6 2024-03-01 Buy
Product number Packaging Price Buy
8.03649 10ml $51.3 Buy
8.03649 25mL $99.5 Buy
8.03649 100mL $261 Buy
8.03649 1L $1170 Buy
38370 25ml $89.6 Buy

N,N'-Diisopropylcarbodiimide Chemical Properties,Uses,Production

Description

Diisopropylcarbodiimide (DIC) is a clear liquid that can be easily dispensed by volume. It slowly reacts with moisture from the air, so for long term storage the bottle should be flushed with dry air or inert gas and sealed tightly. It is used in peptide chemistry as a coupling reagent. It is very toxic and caused contact dermatitis in a laboratory worker.

Chemical Properties

N,N'-Diisopropylcarbodiimide is colorless to pale yellow liquid. Insoluble in water, soluble in benzene, ethanol, ether.

Uses

N,N'-Diisopropylcarbodiimide is used as a reagent in synthetic organic chemistry. It serves as a chemical intermediate and as a stabilizer for Sarin (chemical weapon). It is also used in the synthesis of peptide and nucleic acid. Further, it is used as an antineoplastic and involved in the treatment of malignant melanoma and sarcomas. In addition to this, it is used in the synthesis of acid anhydride, aldehyde, ketone and isocyanate.

Uses

This product is mainly used in amikacin, glutathione dehydrants, as well as in synthesis of acid anhydride, aldehyde, ketone, isocyanate; when it is used as dehydrating condensing agent, it reacts to dicyclohexylurea through short-time reaction under normal temperature. This product can also be used in synthesis of peptide and nucleic acid. It is easy to use this product to react with compound of free carboxy and amino-group into peptide. This product is widely used in medical, health, make-up and biological products, and other synthetic fields.

Definition

ChEBI: A carbodiimide compound having an isopropyl substituent on both nitrogen atoms.

General Description

N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.

Contact allergens

It is used in peptide chemistry as a coupling reagent. It is very toxic and causes contact dermatitis in labora- tory workers.

Synthesis

Add N, N'diisopropylthiourea to the autoclave and use xylene as the solvent. The mass ratio of N, N'diisopropylthiourea to xylene solvent is 2:1. Add Sb2O4 catalyst (the amount of the catalyst is 1% of the total material), and oxygen is introduced. The temperature is increased to 115°C under a pressure of 8MPa for 4h, then lowered. Suction filtration at 15°C, decolorization, and vacuum distillation were used to obtain N, N'-Diisopropylcarbodiimide. The yield is 94.55%, and the purity is 99.55%.
N,N'-Diisopropylcarbodiimide

N,N'-Diisopropylcarbodiimide synthesis

2986-17-6
693-13-0
Synthesis of N,N'-Diisopropylcarbodiimide from N,N'-DIISOPROPYLTHIOUREA

N,N'-Diisopropylcarbodiimide Preparation Products And Raw materials

Raw materials

MOLECULAR SIEVES PACK 4A 1,2-DIETHOXYDISULFANE LEAD CARBONATE Benzene Dichloromethane
N,N'-DIISOPROPYLTHIOUREA

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Preparation Products

4-(PIPERIDINE-1-CARBONYL)PHENYLBORONIC ACID 4-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 3-(2-CYANOETHYLAMINOCARBONYL)PHENYLBORONIC ACID 4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)PHENYLBORONIC ACID 3-TERT-BUTYL-5-(4-BROMOPHENYL)-1,2,4-OXADIAZOLE
4-(3-TERT-BUTYL-1,2,4-OXADIAZOL-5-YL)BENZALDEHYDE 2-TERT-BUTYL-1,3-DIISOPROPYLISOUREA 4,5-Imidazolidinedione, 2,2-dichloro-1,3-bis(1-methylethyl)- BIS(N N'-DIISOPROPYLACETAMIDINATO)NICKE&

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N,N'-Diisopropylcarbodiimide Suppliers

Global( 608)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Z&T Chemical Co., Ltd
+86-21-33561011 13818804961 Sales@ztchemical.com.cn China 402 58
Hangzhou Verychem Science And Technology Co.Ltd
+86-86-57188162785 13606544505 lucy@verychem.com China 1001 58
Changzhou Zechong Biopharma Co., Ltd.
+undefined18621330623 sales@zechongchem.com China 28 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12457 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Nantong Guangyuan Chemicl Co,Ltd 		+undefined17712220823 admin@guyunchem.com China 616 58
Shandong Juchuang Chemical Co., LTD 		+86-18885615001 +86-18885615001 admin@juchuangchem.com China 387 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 951 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Supplier Advantage
Shanghai Z&T Chemical Co., Ltd
58
Hangzhou Verychem Science And Technology Co.Ltd
58
Changzhou Zechong Biopharma Co., Ltd.
58
Hebei Mojin Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Nantong Guangyuan Chemicl Co,Ltd 		58
Shandong Juchuang Chemical Co., LTD 		58
hebei hongtan Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58

Related articles

View Lastest Price from N,N'-Diisopropylcarbodiimide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N,N'-Diisopropylcarbodiimide pictures 2024-04-24 N,N'-Diisopropylcarbodiimide
693-13-0
 US $45.00-40.00 / kg 10kg 99.99% 200Tons Hebei Dangtong Import and export Co LTD
N,N'-Diisopropylcarbodiimide pictures 2024-04-22 N,N'-Diisopropylcarbodiimide
693-13-0
 US $100.00 / kg 1kg 99% 1000 hebei hongtan Biotechnology Co., Ltd
N.n'-diisopropylcarbodiimide pictures 2024-03-15 N.n'-diisopropylcarbodiimide
693-13-0
 US $48.00-31.00 / kg 500kg 99.9 200ton Shandong Juchuang Chemical Co., LTD

N,N'-Diisopropylcarbodiimide Spectrum

N,N'-Diisopropylcarbodiimide(693-13-0)MSN,N'-Diisopropylcarbodiimide(693-13-0)1HNMRN,N'-Diisopropylcarbodiimide(693-13-0)13CNMRN,N'-Diisopropylcarbodiimide(693-13-0)IR1N,N'-Diisopropylcarbodiimide(693-13-0)Raman

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