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BIS-Tris
- CAS No.
- 6976-37-0
- Chemical Name:
- BIS-Tris
- Synonyms
- BIS-TRIS;BIS(2-HYDROXYETHYL)IMINOTRIS(HYDROXYMETHYL)METHANE;2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol;2,2-BIS(HY;''BIS-TRIS'';BIS-TRIS >99%;BIS-TRIS >98%;BIS-TRIS BUFFER;BIS-Tris, ULTROL;2,2-Bis(Hydroxyme
- CBNumber:
- CB4304881
- Molecular Formula:
- C8H19NO5
- Molecular Weight:
- 209.24
- MDL Number:
- MFCD00002853
- MOL File:
- 6976-37-0.mol
- MSDS File:
- SDS
Last updated:2024-04-16 13:12:53
| Melting point | 104 °C(lit.) |
|---|---|
| Boiling point | 466.2±40.0 °C(Predicted) |
| Density | 1.346±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| form | Solution |
| color | Yellow to orange |
| PH | 9.0-10.1 (20-25℃, 1M in water) |
| pka | 6.5(at 25℃) |
| PH Range | 5.8 - 7.2 |
| Odor | Odorless |
| Water Solubility | soluble |
| Sensitive | Air Sensitive |
| λmax | λ: 280 nm Amax: 0.15 |
| BRN | 2205275 |
| InChIKey | OWMVSZAMULFTJU-UHFFFAOYSA-N |
| LogP | -2.26 at 20℃ |
| CAS DataBase Reference | 6976-37-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | Q1XC3631CP |
| EPA Substance Registry System | 1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)- (6976-37-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318 | |||||||||
| Precautionary statements | P280-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-21/22-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-23 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29221980 | |||||||||
| NFPA 704 |
|
BIS-Tris price More Price(91)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHG0004 | BIS-TRIS | 6976-37-0 | 1KIT | $1123 | 2024-03-01 | Buy |
| Sigma-Aldrich | B4429 | BIS-TRIS BioPerformance Certified, cell culture tested, suitable for insect cell culture, ≥98.0% | 6976-37-0 | 1kg | $1220 | 2024-03-01 | Buy |
| Sigma-Aldrich | 391335 | BIS-Tris, ULTROL Grade - CAS 6976-37-0 - Calbiochem Azwitterionicbufferthatexhibitsonlyaverysmallshiftindissociationcons | 6976-37-0 | 100g | $179 | 2024-03-01 | Buy |
| Sigma-Aldrich | 391335 | BIS-Tris, ULTROL Grade - CAS 6976-37-0 - Calbiochem Azwitterionicbufferthatexhibitsonlyaverysmallshiftindissociationcons | 6976-37-0 | 1kg | $898 | 2024-03-01 | Buy |
| Sigma-Aldrich | 14879 | BIS-TRIS BioUltra, ≥99.0% (NT) | 6976-37-0 | 100g | $244 | 2024-03-01 | Buy |
BIS-Tris Chemical Properties,Uses,Production
Chemical Properties
White/clear crystalline powder
Uses
Bis Tris is a commonly used biological buffer for very broad usage in biological systems such as diagnostics, electrophoresis and protein based bioprocessing. The pKa of Bis Tris is 6.36 which makes it a good candidate for biological-based formulations.
Bis Tris is used in a wide variety of biological applications including protein separation buffers, cell culture media, electrophoresis separations and diagnostic reagent formulations.
Uses
It is used as a biological buffer, organic synthesize, chemical & pharmaceutical intermediate. It is suitable for fractionation of hemoglobin.
Uses
Bis-Tris, also known as bis-Tris methane, is a zwitterionic buffering agent used in biochemistry and molecular biology. It is a bis(2-hydroxyethyl)amine and Tris family buffer. Bis Tris is a common component of many buffer systems for various types of electrophoresis. Bis-Tris may form a complex with some common metals, such as Cu(II) and Pb(II), and formation constants should be taken into account when using this buffer in a solution containing metal ions. Bis-Tris can be used as a substitute for the highly toxic buffer cacodylate.
Definition
ChEBI: Bis-tris is a buffer substance useful for calibration of glass electrodes and for the preparation of the biochemical and biological buffer solutions; pKa = 6.46 at 25 ℃. It has a role as a buffer. It is functionally related to a member of tris.
Flammability and Explosibility
Not classified
Purification Methods
Crystallise BIS-TRIS from hot 1-butanol and dry it in a vacuum at 25o. N,N-Bis-(2-hydroxyethyl)glycine (BICINE) See in “Amino Acids and Peptides”, Chapter 6.
BIS-Tris Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 425)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| XuZhou Magic Biotechnology Co., Ltd. | +undefined13921770081 | SVP01@magicbiotech.cn | China | 92 | 58 |
| Suzhou Genemill Biotechnology Co.,Ltd | +86-0512-65917170; +8615862502491 | aimeegao@genemill.com | China | 39 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12453 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7378 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from BIS-Tris manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | BIS-Tris
6976-37-0
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-02-20 | Bis-Tris
6976-37-0
|
US $0.00 / kg | 1kg | 0.995 | 1000tons | Suzhou Genemill Biotechnology Co.,Ltd | |
|
|
2024-02-20 | Bis-Tris -Tris(hydroxymethyl)aminomethan
6976-37-0
|
US $0.00 / kg | 1kg | 0.995 | 1000tons | Suzhou Genemill Biotechnology Co.,Ltd |
-
- BIS-Tris
6976-37-0
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Bis-Tris
6976-37-0
- US $0.00 / kg
- 0.995
- Suzhou Genemill Biotechnology Co.,Ltd
-
- Bis-Tris -Tris(hydroxymethyl)aminomethan
6976-37-0
- US $0.00 / kg
- 0.995
- Suzhou Genemill Biotechnology Co.,Ltd
6976-37-0(BIS-Tris)Related Search:
4,4'-Methylenedianiline
2-(METHYLSULFONYL)ETHANOL
Hydroxyethyl starch
Tricine
Tris(hydroxymethyl)nitromethane
1of4
2,2-BIS(HYDROXYETHYL)-(IMINOTRIS)-(HYDROXYMETHYL)-METHANE
2-BIS[2-HYDROXYETHYL]AMINO-2-[HYDROXYMETHYL]1,3-PROPANEDIOL
2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-3-propanediol
Bis Tris Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane
Bis Tris, Molecular Biology Grade Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)methane, Molecular Biology Grade
Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane~Bis-TRIS
Bis-Tris (2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol)
BIS-TRIS BIOULTRA, >= 99.0% (NT)
BIS-TRIS, BIOPERFORMANCE CERTIFIED&
2,2-Bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol
2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol
Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane
Bis-tris
BIS-Tris, ULTROL
Bis-Tris, Cell culture reagent
BIS(2-HYDROXYETHYL)IMINO-TRIS(HYDROXYMETHYL)PROPANE
BIS(2-HYDROXYETHYL)AMINO-TRIS(HYDROXYMETHYL)METHANE
BIS(HYDROXYETHYL)IMINO-TRIS-(HYDROXYMETHYL)-METHANE
''BIS-TRIS''
BIS-TRIS BUFFER
2,2-BIS(HYDROXYMETHYL)-2,2',2''-NITRILOETHANOL
2,2-BIS-(HYDROXYMETHYL)-2,2',2'-NITRILOTRIETHANOL
2,2-BIS(HYDROXYMETHYL)-2,2',2''-NITRILOTRIETHANOL
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, 99+%
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, for biochemistry, 99+%
Bis[(2-hydroxyethyl)amino]-2-(hydroxymethyl)- 1,3-propanediol
1,3-Propanediol, 2-bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-
Bis(2-hydroxyethyl)iminotris(hydroxylmethyl)methane
BIS-TRIS,BIOLOGICALBUFFER
Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)propane
BIS(2-HYDROXYETHYL)-TRIS(HYDROXYMETHYL)METHANE
BIS-TRIS (BIS(2-HYDROXYETHYL)AMINO-TRIS(HYDROXYMETHYL)METHANE)
BIS(2-HYDROXYETHYL)IMINOTRIS(HYDROXYMETHYL)METHANE(BIS-TRIS)
Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane >98%
Bis(2-hydroxyethyl)-imino-tris-(hydroxymethyl)-methane biological buffer
bis-tris cell culture tested
bis-tris free base
bis-tris free base sigmaultra
BIS-Tris, ULTROL Grade
2,2-BIS(HYDROXYMETHYL)-2,2',2''-NITRILO- TRIETHANOL, 98+%
BIS-TRIS, BIOTECHNOLOGY PERFORMANCE CERT IFIED
BIS(2-HYDROXYETHYL)AMINO-TRIS(HYDROXYMET L)-METHAN
BIS(2-HYDROXYETHYL)IMINO-TRIS(HYDROXYMETHYL)PROPANE （BIS-TRIS）
(2-Hydroxyethyl)iMinotris(hydroxyMethyl)Methane(BIS-TRIS)
2-[bis(2-hydroxyethyl)aMino]-3-(hydroxyMethyl)pentane-1,5-diol
Bis(2-hydroxyethyl)aMinotris(hydroxyMethyl)Methane
Bis(2-hydroxyethyl)iMinotris(hydroxyMethyl)Methan
BIS-HYDROXYETHYL TROMETHAMINE
2,2-Bis(hydroxyMethyl)-2,2',2''-nitrilotriethanol (BIS-TRIS)
BIS-TRIS >99%
BIS-TRIS Vetec(TM) reagent grade, >=98%, RNase and DNase free
COLOREX CLOSTRIDIUM DIFFICILE 90MM
INDICATOR PAPER ROTA PH 1-10 ROLL
ROSE BENGAL CHLOR.PENASE 90MM DOUBLE-WR.
Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane [Good's buffer component for biological research]
2,2-Bis(hydroxymethyl)-2,2μ,2-nitrilotriethanol, 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol, Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, 99+%, for biochemistry
2,2-Bis(hydroxymethyl)-2,2',2''-nitrilotriethanol, for biochemistry
2,2'-[2-Hydroxy-1,1-bis(hydroxymethyl)ethylimino]bisethanol
2,2-Bis(hydroxymethyl)-(2,2',2''-nitrilotrisethanol)
2,2-BIS(HY