CYTIDINE 5'-DIPHOSPHOCHOLINE
- CAS No.
- 987-78-0
- Chemical Name:
- CYTIDINE 5'-DIPHOSPHOCHOLINE
- Synonyms
- CITICOLINE;CDP-CHOLINE;citicholine;CYTIDINE DIPHOSPHATE CHOLINE;Reagin;somazina;Audes;cereb;Rexort;CDPC-H
- CBNumber:
- CB4343598
- Molecular Formula:
- C14H26N4O11P2
- Molecular Weight:
- 488.33
- MDL Number:
- MFCD00868097
- MOL File:
- 987-78-0.mol
| Melting point | >185°C (dec.) |
|---|---|
| alpha | D25 +19.0° (c = 0.86 in H2O) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Water (Sparingly) |
| pka | 4.4(at 25℃) |
| form | Solid |
| color | White |
| Stability | Moisture Sensitive |
| InChIKey | RZZPDXZPRHQOCG-APGYLPRWNA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP([O-])(=O)OCC[N+](C)(C)C)O[C@H]1N1C=CC(N)=NC1=O)O |&1:1,2,3,21,r| |
| LogP | -7.070 (est) |
| CAS DataBase Reference | 987-78-0(CAS DataBase Reference) |
| FDA UNII | 536BQ2JVC7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| Toxicity | LD50 in mice, rats (mg/kg): 4600 ±335, 4150 ±370 i.v.; both species 8 g/kg orally (Grau) |
CYTIDINE 5'-DIPHOSPHOCHOLINE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C998313 | Cytidine5''-Diphosphocholine | 987-78-0 | 250mg | $45 | 2021-12-16 | Buy |
| TRC | C998313 | Cytidine5''-Diphosphocholine | 987-78-0 | 2.5g | $70 | 2021-12-16 | Buy |
| AK Scientific | K771 | Citicoline | 987-78-0 | 25g | $81 | 2021-12-16 | Buy |
| ApexBio Technology | C6983 | Citicoline | 987-78-0 | 500mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0009633 | Citicoline 99.51% | 987-78-0 | 500mg | $90 | 2021-12-16 | Buy |
CYTIDINE 5'-DIPHOSPHOCHOLINE Chemical Properties,Uses,Production
Description
Citicoline whose chemical name choline cytosine nucleoside-5'-diphosphate monosodium salt, is a precursor for lecithin biosynthesis, and when brain function declines, the content of lecithin in brain tissue is significantly reduced.
Originator
Nicholin,Cyanamid,Italy,1971
Uses
Cytidine 5'-Diphosphocholine is used as antidepressant, 5HT uptake inhibitor.
Definition
ChEBI: CDP-choline is a member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a human metabolite, a psychotropic drug, a neuroprotective agent, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a member of phosphocholines and a member of nucleotide-(amino alcohol)s. It is functionally related to a CDP. It is a conjugate base of a CDP-choline(1+).
Manufacturing Process
A 250 ml conical flask containing 30 ml of a reaction liquor (pH 7.0) having a
composition of 7.38 mg/ml of disodium salt of CMP (cytidine-5'-
monophosphate), 24 mg/ml of choline, 10 mg/ml of glucose, 100 mg/ml of
acetone-dried cells of Brevibacterium ammoniagenes ATCC 6872, 11.6 mg/ml
of monopotassium phosphate, 20 mg/ml of dipotassium phosphate and 2.96
mg/ml of magnesium sulfate, (MgSO4·7H2O), was subjected to culturing at
30°C for 4 hours. Cytidine diphosphate choline was formed and accumulated
at a concentration of 3.8 mg/ml in the culture liquor.
The pH of 1.2 liters of filtrate containing 3.8 mg/ml of cytidine diphosphate
choline, obtained by removing solid matters from the culturing liquor, was
adjusted to a pH of 8.5 with a 0.5 N KOH solution. The filtrate was passed
through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic
acid type). After washing the resin with water, a formic acid solution was
passed through the column with gradual increase in the concentration of
formic acid (until 0.04 N max.). A fraction of cytidine diphosphate choline was
collected by elution according to the so-called gradient elution method and
absorbed onto carbon powders. Then, elution was effected with acetone, and
the eluate was concentrated and dried. 1.3 g of cytidine diphosphate choline
powders were obtained.
Therapeutic Function
Cerebral circulation stimulant
CYTIDINE 5'-DIPHOSPHOCHOLINE Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Langyou International Trading Co., Ltd | +8618874586545 | linda@xrdchem.cn | China | 197 | 58 |
| Hangzhou Weitai Biological Pharmaceutical Co.,Ltd. | +8613282012786 | sales@weitai-pharmaceutical.com | China | 61 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | sales006@ingredients-lonier.com | China | 2596 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 | erin@hbldbiotech.com | China | 878 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 269 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 282 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
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- May 6，2022
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View Lastest Price from CYTIDINE 5'-DIPHOSPHOCHOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | CYTIDINE 5'-DIPHOSPHOCHOLINE
987-78-0
|
US $0.00-0.00 / kg | 1kg | 99% | 500 | Wuhan Haorong Biotechnology Co.,Ltd | |
 |
2024-04-24 | CYTIDINE 5'-DIPHOSPHOCHOLINE / Haocolin / Neucolis
987-78-0
|
US $0.00-0.00 / kg | 1kg | 99% | 2000 | Wuhan Haorong Biotechnology Co.,Ltd | |
 |
2024-04-24 | Citicoline
987-78-0
|
US $1.00-9.90 / g | 1g | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd |
-
- CYTIDINE 5'-DIPHOSPHOCHOLINE
987-78-0
- US $0.00-0.00 / kg
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd
-
- CYTIDINE 5'-DIPHOSPHOCHOLINE / Haocolin / Neucolis
987-78-0
- US $0.00-0.00 / kg
- 99%
- Wuhan Haorong Biotechnology Co.,Ltd
-
- Citicoline
987-78-0
- US $1.00-9.90 / g
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd