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Bakuchiol

Bakuchiol structure

CAS No.: 10309-37-2

Chemical Name:: Bakuchiol

Synonyms: BAKUCHIOL;Backuchiol;Drupanol;(S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dien-1-yl)phenol;UP 256;BAKUCHIOL;Aids046581;Aids-046581;98%Bakuchiol;BAKUCHIOL(SH)

CBNumber:: CB4365255

Molecular Formula:: C18H24O

Molecular Weight:: 256.38

MDL Number:: MFCD01707441

MOL File:: 10309-37-2.mol

MSDS File:: SDS

Last updated:2024-04-15 18:41:30

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Bakuchiol Properties

Boiling point	391℃
Density	0.963
vapor pressure	0Pa at 25℃
refractive index	1.4500 (estimate)
Flash point	177℃
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
pka	10.10±0.26(Predicted)
color	Oil
optical activity	[α]/D +24.0 to +30.0°, c = 0.1 in chloroform
BRN	3611720
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey	LFYJSSARVMHQJB-WYMLVPIESA-N
LogP	5.09 at 20℃ and pH6.31
Surface tension	43.92mN/m at 1g/L and 20℃
EWG's Food Scores	1
FDA UNII	OT12HJU3AR

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
WGK Germany	3
RTECS	SL3785000
Toxicity	LD50 orl-mus: 2560 mg/kg MZHUDX 42,646,80

Bakuchiol price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SMB00604	Bakuchiol ≥95%	10309-37-2	20mg	$313	2024-03-01	Buy
Sigma-Aldrich	68612	Bakuchiol analytical standard	10309-37-2	10mg	$262	2022-05-15	Buy
Cayman Chemical	11684	Bakuchiol ≥95%	10309-37-2	5mg	$53	2024-03-01	Buy
Cayman Chemical	11684	Bakuchiol ≥95%	10309-37-2	10mg	$98	2024-03-01	Buy
Cayman Chemical	11684	Bakuchiol	10309-37-2	25mg	$221	2024-03-01	Buy

Product number	Packaging	Price	Buy
SMB00604	20mg	$313	Buy
68612	10mg	$262	Buy
11684	5mg	$53	Buy
11684	10mg	$98	Buy
11684	25mg	$221	Buy

Bakuchiol Chemical Properties,Uses,Production

Description

Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.It has the follow effects: 1.Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2.Protects against acute lung injury.3.Displays neuroprotective and anti-inflammatory effects.

Uses

(S)-Bakuchiol is a meroterpen found in the medicinal resinous shrub Psoralea glandulosa. An analogue of Resveratrol (R150000) with antifungal and anti-tumor effects. Studies have shown that Bakuchiol is a potent cytotoxic agent that exhibiting concentration dependent growth inhibition against leukemia cancer cells.

Safety Profile

Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andfumes.

Mode of action

The research found that BAK upregulates the expression of the antiapoptotic molecule Bcl2 and downregulates the expression of the proapoptotic molecules Bax and caspase-3 by activating the silent information regulator 1 (SIRT1) signaling pathway and thereby inhibits mitochondrial damage and ameliorates myocardial IRI. BAK promotes apoptosis in hepatic astrocytes through the caspase-3-dependent pathway and inhibits liver fibrosis. In addition, BAK exerts a protective effect against hepatotoxicity induced by tert-butyl hydroperoxide (tBH), tetrachloromethane (CCl4), and d-galactosamine (D-GalN). BAK (60?mg/kg) treatment significantly reduces edema and pathological changes in lung tissues by inhibiting intense inflammation and exerting protective effects in the lung under sepsis conditions[5-6].

References

1) Adhikari et al. (2007), Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants; J. Clin. Biochem. Nutr., 40 174
2) Kim et al. (2013), Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage; Toxicol. Appl. Pharmacol., 269 109
3) Zhang et al. (2017), Bakuchiol protects against acute lung injury in septic mice; Inflammation, 40 351
4) Kim et al. (2016), Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia; Molecules, 21 E1076
[5] Zhenlong Xin . “Bakuchiol: A newly discovered warrior against organ damage.” Pharmacological research 141 (2019): Pages 208-213.
[6] Jianyu Feng. “Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1.” Apoptosis 71 1 (2016): 532–545.

Bakuchiol Preparation Products And Raw materials

Raw materials

Preparation Products

Bakuchiol Suppliers

Global( 316)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chemsigma International Co., Ltd.	+86-18136843612 +86-19951791336	info@chemsigma.com	China	963	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618829768577	gao490372054@gamil.com	China	1250	58
Shaanxi LonierHerb Bio Technology Co Ltd	+86-86-+86-86-029-87551862 +8617702909819	sales006@ingredients-lonier.com	China	2596	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	296	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	224	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	269	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7378	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55

Supplier	Advantage
Chemsigma International Co., Ltd.	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Shaanxi LonierHerb Bio Technology Co Ltd	58
Chongqing Zhihe Biopharmaceutical Co., Ltd.	58
BINBO BIOLOGICAL CO.,LTD	58
Sinoway Industrial co., ltd.	58
Hangzhou ICH Biofarm Co., Ltd	58
Wuhan Haorong Biotechnology Co.,ltd	58
Henan Fengda Chemical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

Anti-aging effects of Bakuchiol
Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with prom....
Dec 26，2023

View Lastest Price from Bakuchiol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-15	Bakuchiol 10309-37-2	US $0.00 / kg	1kg	99.8%	1000 kg	BINBO BIOLOGICAL CO.,LTD
2024-04-10	Bakuchiol 10309-37-2	US $800.00-550.00 / Kg/Bag	1Kg/Bag	98.5% up / EP	20 tons	Sinoway Industrial co., ltd.
2024-04-09	Bakuchiol 10309-37-2	US $0.00 / g	1g	≥98% HPLC	1000kg	Changsha Staherb Natural Ingredients Co., Ltd.

Bakuchiol
10309-37-2
US $0.00 / kg
99.8%
BINBO BIOLOGICAL CO.,LTD

Bakuchiol
10309-37-2
US $800.00-550.00 / Kg/Bag
98.5% up / EP
Sinoway Industrial co., ltd.

Bakuchiol
10309-37-2
US $0.00 / g
≥98% HPLC
Changsha Staherb Natural Ingredients Co., Ltd.

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P-(3,7-DIMETHYL-3-VINYLOCTA-TRANS-1,6-DIMETHYL) PHENOL 7-dimethyl-1,6-octadienyl)-4-(3-ethenyl-(s-(e))-pheno BACTRIS GASIPAES FRUIT JUICE (S)-Bakuchiol 4-[(1E,3S)-3,7-Dimethyl-3-vinyl-1,6-octadienyl]phenol 4-[(1E,3S)-3-Vinyl-3,7-dimethyl-1,6-octadienyl]phenol 4-[(S,E)-3-Ethenyl-3,7-dimethyl-1,6-octadienyl]phenol Aids046581 Aids-046581 Phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadienyl]- BAKUCHIOL(SH) (S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dienyl)phenol 4-[(1E,3S)-3-Ethenyl-3,7-dimethyl-1,6-octadien-1-yl]phenol UP 256 4-(3,7-DIMETHYL-3-VINYL-OCTA-1,6-DIENYL)-PHENOL BAKUCHIOL(RG) 4-[(1E,3S)-3-ethenyl-3,7-diMethyl-1,6-octadienyl]-Phenol 4-(3,7-Dimethyl-3-vinylocta-1,6-dien-1-yl)phenol 4-[(1E,3S)-3,7-Dimethyl-3-vinyl-1,6-octadien-1-yl]phenol 4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol Nano Liposomal (S)-(+)-Bakuchiol Bakuchiol 98% Bakuchiol, 98%, from Psoralea corylifolia L. Bakuchiol powder Bakuchiol ((S)-(+)-Bakuchiol) Phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]- 98% pure Bakuchiol 98%Bakuchiol (+)-Bakuchiol (1e 3s)-3-enthenyl-3 7-dimethyl octa-1 6-dienyl]phenol TIANFU CHEM 4-(3,7-DIMETHYL-3-VINYL-OCTA-1,6-DIENYL)-PHENOL BAKUCHIOL Drupanol Backuchiol (S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dien-1-yl)phenol Nano-Liposomal BAKUCHIOL, Water-Soluble BAKUCHIOL BAKUCHIOL Cullen corylifolium Psoralen phenol 10309-37-2 10309-27-2 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract