10-PROPOXY-DECANOIC ACID
- CAS No.
- 119290-12-9
- Chemical Name:
- 10-PROPOXY-DECANOIC ACID
- Synonyms
- O-11;O11,O 11;10-PROPOXY-DECANOIC ACID;11-OXATETRADECANOIC ACID;Decanoic acid, 10-propoxy-;HSRAJJQTYQHRSA-UHFFFAOYSA-N;10-(propoxy)decanoyl-coenzyme A
- CBNumber:
- CB4408954
- Molecular Formula:
- C13H26O3
- Molecular Weight:
- 230.34
- MDL Number:
- MFCD03412034
- MOL File:
- 119290-12-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501 | |||||||||
| NFPA 704 |
|
10-PROPOXY-DECANOIC ACID price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 90510 | O-11 ≥98% | 119290-12-9 | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 90510 | O-11 ≥98% | 119290-12-9 | 5mg | $210 | 2024-03-01 | Buy |
| Cayman Chemical | 90510 | O-11 ≥98% | 119290-12-9 | 10mg | $371 | 2024-03-01 | Buy |
| AK Scientific | 1138AH | 10-Propoxy-decanoicacid | 119290-12-9 | 10mg | $510 | 2021-12-16 | Buy |
10-PROPOXY-DECANOIC ACID Chemical Properties,Uses,Production
Definition
ChEBI: 10-propoxydecanoic acid is a medium-chain fatty acid.
Biological Activity
O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing Trypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50 of less than 1 μM in a cell culture assay.1,2 The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1 O-11 exhibits essentially no anti-fungal activity when assayed using C. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3
References
1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991) 2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994) 3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992)
10-PROPOXY-DECANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
10-PROPOXY-DECANOIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2210 | 55 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
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