ChemicalBook
Chinese Japanese Germany

Gemcitabine

Description References
Gemcitabine
Gemcitabine
CAS No.
95058-81-4
Chemical Name:
Gemcitabine
Synonyms
Zefei;Gemcel;GemLip;LY-18011;Folfugem;NSC 613327;GeMcitabin;Gamcitabine;GeMictabine;GEMCITABINE
CBNumber:
CB4438054
Molecular Formula:
C9H11F2N3O4
Formula Weight:
263.2
MOL File:
95058-81-4.mol

Gemcitabine Properties

Melting point:
168,64 C
alpha 
365 +425.36°; D +71.51°
CAS DataBase Reference
95058-81-4(CAS DataBase Reference)

SAFETY

Hazard Codes  Xn,Xi
Risk Statements  21-36/38-46-62-63
Safety Statements  25-26-36/37-53
Hazardous Substances Data 95058-81-4(Hazardous Substances Data)

Gemcitabine price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 11690 Gemcitabine ≥98% 95058-81-4 10mg $40 2017-11-08 Buy
Cayman Chemical 11690 Gemcitabine ≥98% 95058-81-4 25mg $71 2017-11-08 Buy
Cayman Chemical 11690 Gemcitabine ≥98% 95058-81-4 50mg $135 2017-11-08 Buy
Cayman Chemical 11690 Gemcitabine ≥98% 95058-81-4 100mg $240 2017-11-08 Buy

Gemcitabine Chemical Properties,Uses,Production

Description

Gemcitabine (2’,2’-difluorodeoxycytidine; dFdCyd) is a novel deoxycytidine analogue with both structural and metabolic similarities to cytarabine. It has a broad spectrum of antitumor activity in preclinical murine leukemia and solid tumor models. This drug requires intracellular phosphorylation that results in the accumulation of difluorodeoxycytidine triphosphate (dFdCTP). The dFdCTP competes with deoxycytidine triphosphate (dCTP) for incorporation into DNA, which in turn inhibits DNA synthesis and terminates DNA chain elongation. In addition, this drug reduces intracellular deoxynucleoside triphosphate pools, presumably through the inhibition of ribonucleotide reductase.
Gemcitabine is used alone or with other treatments/medications to treat certain types of cancer (including breast cancer, non-small cell lung cancer, ovarian cancer, pancreatic cancer, bladder cancer, bone cancer, Ewing’s sarcoma, mesenchymal chondrosarcoma osteosarcoma, dedifferentiated chondrosarcoma, head and neck cancers-cancer of the nasopharynx, hepatobiliary cancers including gallbladder cancer, Hodgkin lymphoma, kidney cancer, malignant pleural mesothelioma, non Hodgkin lymphoma, non-melanoma skin cancer – dermatofibrosarcoma protuberans (DFSP), occult primary, small cell lung cancer, soft tissue sarcoma, testicular cancer, thymic malignancies, uterine malignancies). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells. One commercial product of gemcitabine is Gemzar, which is supplied in a sterile form for intravenous use only.

References

[1] H. A. Burris, M. J. Moore, J. Andersen, M. R. Green, M. L. Rothenberg, M. R. Modiano, M. C. Cripps, R. K. Portenoy, A. M. Storniolo, P. Tarassoff, R. Nelson, F. A. Dorr, C. D. Stephens, D. D. Von Hoff (1997) Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial, 15, 2403-2413
[2] http://www.webmd.com/drugs/2/drug-13451/gemcitabine-intravenous/details

Uses

Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites. It is used alone or in combination with other medicines to treat cancer of the breast, ovary, pancreas, and lung. Gemcitabine interferes with the growth of cancer cells, which a

Gemcitabine Preparation Products And Raw materials

Raw materials

Preparation Products


Gemcitabine Suppliers

Global( 268)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19953 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 9974 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1372 55
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 458 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 887 50
Lianyungang TengFa Biological Technology Co. Ltd 0518-85475186 18360676350
0518-85475186 wang666xt@163.com China 36 55
Target molecule Corp. 857-239-0968
857-239-8801 market@targetmol.com United States 2567 60
Chemleader Biomedical Co., Limited. 021-58180488; 58180499
021-58180499-803 sales@chemleader.com.cn sales@Medchemleader.com China 393 58
BOC Sciences
info@bocsci.com United States 9930 65

95058-81-4(Gemcitabine)Related Search:


  • GEMCITABINE HCL USP
  • 2'-Deoxy-2',2'-difluro cytidine Hydrochloride
  • C9H11F2N3O4
  • 2'-Deoxy-2',2'-difluoro-D-cytidine
  • 2''-DEOXY-2'',2''-DIFLUOROCYTIDINE(GEMCITABINE)
  • 2',2'-Difluorodeoxycytidine
  • Cytidine, 2'-deoxy-2',2'-difluoro-
  • gemicitabine
  • NSC 613327
  • gencitabine base
  • 2',2'-Difluorodeoxycytidine (Gemcitabine base)
  • API
  • GEMCITABINE (2''-DEOXY-2'', 2''-DIFLUOROCYTIDINE)
  • LY-18011
  • 3-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate
  • Gecitabine base
  • Antineoplastic drug, difluorine nucleoside analog
  • Folfugem
  • Gamcitabine
  • Gemcel
  • GemLip
  • Zefei
  • 4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one (Gemcitabine base)
  • GeMcitabine T8
  • GeMcitabine API
  • 122111-11-9 D-erythro-pentofuranose
  • GeMictabine
  • dFdC, dFdCyd, LY-188011
  • Antineoplastic
  • GeMcitabin
  • 2'-Deoxy-2',2'-difluorocytidine, >=99%
  • Inhibitors
  • Gemcitabine free base
  • 1-(4-Amino-2-oxo-1H-pyrimidin-1-yl)-2-deoxy-2,2-difluoro-beta-D-ribofuranose
  • 2'-Deoxy-2',2'-difluro cytidine
  • 2'-DEOXY-2',2'-DIFLUOROCYTIDINE
  • 4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
  • 95058-81-4
  • GEMCITABINE
Copyright 2017 © ChemicalBook. All rights reserved