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dBET6

dBET6 structure

CAS No.: 1950634-92-0

Chemical Name:: dBET6

Synonyms: dBET6;DBET6;DBET-6 ;DBET 6;dBET-6,Apoptosis,PROTACs,Inhibitor,inhibit,dBET6,Epigenetic Reader Domain,dBET 6;2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide;(6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-;2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02?]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[8-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]octyl]acetamide

CBNumber:: CB44718444

Molecular Formula:: C42H45ClN8O7S

Molecular Weight:: 841.37

MDL Number:: MFCD31692407

MOL File:: 1950634-92-0.mol

Last updated:2023-07-12 16:41:06

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dBET6 Properties

Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:60.0(Max Conc. mg/mL);71.32(Max Conc. mM) Ethanol:35.0(Max Conc. mg/mL);41.6(Max Conc. mM)
form	A solid
pka	10.68±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

dBET6 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0047679	dBET6 99.40%	1950634-92-0	5mg	$140	2021-12-16	Buy
ChemScene	CS-0047679	dBET6 99.40%	1950634-92-0	10mg	$210	2021-12-16	Buy
Biosynth Carbosynth	BD177448	dBET6 NEW	1950634-92-0	25mg	$292.5	2021-12-16	Buy
Biosynth Carbosynth	BD177448	dBET6 NEW	1950634-92-0	50mg	$390	2021-12-16	Buy
ChemScene	CS-0047679	dBET6 99.40%	1950634-92-0	25mg	$420	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0047679	5mg	$140	Buy
CS-0047679	10mg	$210	Buy
BD177448	25mg	$292.5	Buy
BD177448	50mg	$390	Buy
CS-0047679	25mg	$420	Buy

dBET6 Chemical Properties,Uses,Production

Description

dBET6 is a potent, selective, and cell-permeable PROTAC connected by ligands for Cereblon and BET and has antitumor activity.

Definition

ChEBI: DBET6 is an organic molecular entity.

Biological Activity

dBET6 is a BET bromodomains PROTAC degrader with good cell permeability, binding to BRD4 with an IC50 of 14 nM. It also induces down-regulation and apoptosis of c-MYC.

target

Target	Value
BRD4 ()	14 nM

storage

Store at -20°C

dBET6 Preparation Products And Raw materials

Raw materials

Preparation Products

dBET6 Suppliers

Global( 55)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Jiyi Biological Technology Co., LTD	021-54135696 18516235431	shgegenetech@163.com	China	986	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Aladdin Scientific	58
Shanghai Jiyi Biological Technology Co., LTD	55

dBET6 DBET6;DBET-6 ;DBET 6 (6S)-4-(4-Chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)- 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide dBET-6,Apoptosis,PROTACs,Inhibitor,inhibit,dBET6,Epigenetic Reader Domain,dBET 6 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02?]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[8-[[2-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]oxyacetyl]amino]octyl]acetamide 1950634-92-0 C42H45ClN8O7S