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4-Nitro-3-trifluoromethyl aniline

CAS No.
393-11-3
Chemical Name:
4-Nitro-3-trifluoromethyl aniline
Synonyms
FLU-1;4-Nitro-α,α,α;TIMTEC-BB SBB006652;Flutamide Impurity A;Nilutamide Impurity 3;Nilutamide impurity B CRS;FlutaMide Related CoMpound A;2-Nitro-5-aminobenzotriluoride;5-AMINO-2-NITROBENZOTRIFLUORIDE;3-AMINO-6-NITROBENZOTRIFLUORIDE
CBNumber:
CB4483928
Molecular Formula:
C7H5F3N2O2
Molecular Weight:
206.12
MDL Number:
MFCD00014717
MOL File:
393-11-3.mol
MSDS File:
SDS
Last updated:2023-09-11 17:45:53

4-Nitro-3-trifluoromethyl aniline Properties

Melting point 125-129 °C (lit.)
Boiling point 326.4±42.0 °C(Predicted)
Density 1.4711 (estimate)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka -0.22±0.10(Predicted)
color Yellow to Orange-Yellow
BRN 2650702
InChIKey UTKUVRNVYFTEHF-UHFFFAOYSA-N
CAS DataBase Reference 393-11-3(CAS DataBase Reference)
FDA UNII 15YY91105I
NIST Chemistry Reference 5-Amino-2-nitrobenzotrifluoride(393-11-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36-36/37
WGK Germany  2
Hazard Note  Irritant
HS Code  29214200
NFPA 704
1
2 0

4-Nitro-3-trifluoromethyl aniline price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A68807 4-Nitro-3-(trifluoromethyl)aniline 98% 393-11-3 5g $57.6 2024-03-01 Buy
Sigma-Aldrich 1285997 Flutamide Related Compound A United States Pharmacopeia (USP) Reference Standard 393-11-3 20mg $1300 2024-03-01 Buy
TCI Chemical A0377 5-Amino-2-nitrobenzotrifluoride >98.0%(GC) 393-11-3 5g $18 2024-03-01 Buy
TCI Chemical A0377 5-Amino-2-nitrobenzotrifluoride >98.0%(GC) 393-11-3 25g $60 2024-03-01 Buy
Alfa Aesar A13798 4-Nitro-3-(trifluoromethyl)aniline, 98% 393-11-3 1g $31.65 2024-03-01 Buy
Product number Packaging Price Buy
A68807 5g $57.6 Buy
1285997 20mg $1300 Buy
A0377 5g $18 Buy
A0377 25g $60 Buy
A13798 1g $31.65 Buy

4-Nitro-3-trifluoromethyl aniline Chemical Properties,Uses,Production

Description

4-Nitro-3-trifluoromethyl aniline is an organic intermediate, which can be used to prepare 4-bromo-2-nitrotrifluorotoluene, an intermediate of medicine and optical waveguide materials, and flutamide, a non steroidal anti androgen drug.

Chemical Properties

Orange to Brown to Dark red powder to crystal.

Uses

4-Nitro-3-(trifluoromethyl)aniline is a metabolite of Flutamide (F598850) (FLU-1 or M2).

Uses

A metabolite of Flutamide (FLU-1 or M2).

Synthesis

The thiazolium salt 3 (3.30 mg, 0.0122 mmol) was added to a solution of 1-azido-4-nitrobenzene (0.122 mmol) and t-BuOH (18.0 mg, 0.244 mmol) in degassed THF (0.50 mL) under argon at r.t. The resulting suspension was stirred for 5 min, and then NaOt-Bu (23.4 mg, 0.244 mmol) was added in one portion, and the mixture was stirred (Table 2). Water (2 mL) was added, and the products were extracted with EtOAc (2 ?á 2 mL), the combined organic phase was dried over anhyd MgSO4, filtered, and concentrated in vacuo. Purification was achieved by passing the resulting residue through a short pad of silica (eluting with 50% light PE-EtOAc) unless otherwise stated.
4-Nitro-3-trifluoromethyl aniline, Time: 12 h, Pale yellow solid (21.0 mg, 84%). (70:30 petrol-EtOAc) 0.5; mp 90-93 ??C (lit., 92-93 ??C); IR (FTIR, CHCl3) |ímax cm-1: 3535 (NH2), 3434 (NH2), 1635, 1592 (NO2), 1520 (NO2), 1119; 1H NMR (400 MHz, DMSO-6) 8.59 (d, = 2.7 Hz, 1H), 8.55 (dd, = 9.3, 2.7 Hz, 1H), 7.55 (br s, 2H), 7.32 (d, = 9.3 Hz, 1H); 13C NMR (100 MHz, DMSO-6) 151.8 (C), 135.0 (C), 128.7 (CH), 123.7 (J = 5.9 Hz, F3N2NaO2 [M+Na]+, 229.0195; found, 229.0195.
Synthesis_393-11-3
Fig. The synthetic of 4-Nitro-3-trifluoromethyl aniline

351-36-0
393-11-3
Synthesis of 4-Nitro-3-trifluoromethyl aniline from 3-(TRIFLUOROMETHYL)ACETANILIDE

4-Nitro-3-trifluoromethyl aniline Preparation Products And Raw materials

Global( 405)Suppliers
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View Lastest Price from 4-Nitro-3-trifluoromethyl aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Nitro-3-trifluoromethyl aniline  pictures 2023-11-09 4-Nitro-3-trifluoromethyl aniline
393-11-3
US $600.00 / g 1g 98% 10tons qingdao future trading Co., Ltd
5-Amino-2-nitrobenzotrifluoride pictures 2023-10-20 5-Amino-2-nitrobenzotrifluoride
393-11-3
US $90.00-70.00 / kg 1kg 99% 10000/month Anhui Zhongda Biotechnology Co., Ltd
4-Nitro-3-trifluoromethyl aniline pictures 2023-10-10 4-Nitro-3-trifluoromethyl aniline
393-11-3
US $7.00-123.00 / g 1g 99% 100kg Wuhan Cell Pharmaceutical Co., Ltd
4-Nitro-α,α,α 4-Nitro-3-(trifluoromethyl)aniline (FLU-1) 5-Amino-2-nitrobenzotrifluoride, 4-Nitro-α,α,α-trifluoro-m-toluidine 4-nitro-3-(trifluoromethyl)benzenamine FLU-1 4-Nitro-3-(trifluoromethyl)aniline ,98% FlutaMide Related CoMpound A The 4- nitro-3- threetrifluoroMethylaniline 4-Nitro-4-(trifluoromethyl)aniline Flutamide Related Compound A (20 mg) (4-nitro-3-(trifluoromethyl)aniline) 4-Nitro-3-(trifluoromethyl)aniline 98% 2-NITRO-5-AMINO BENZOTRIFLUORIDE 5-AMINO-2-NITROBENZOTRIFLUORIDE 4-NITRO-3-(TRIFLUOROMETHYL)ANILINE 4-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINE 3-AMINO-6-NITROBENZOTRIFLUORIDE TIMTEC-BB SBB006652 Benzenamine, 4-nitro-3-(trifluoromethyl)- 4-Nitro-α,α,α-trifluoro-m-toluidine 3-Trifluoromethyl-4-nitroaniline 4-Nitro-3-(trifluoromethyl) aniline (3-Amino-6-nitrobenzotrifluoride) 4-Nitro-3-aminobenzotrifluoride 4-Nitro-3-trifluoromethylaniline(Flutamide impurity) 5-Amino-2-nitrobenzotrifluoride,97% 5-Amino-2-nitrobenzotrifluoride 98% 5-Amino-2-nitrobenzotrifluoride98% 2-NITRO-5-AMINOBENZOTRIFLUORIDE(3-TRIFLUOROMETHYL-4-NITROANILINE) 3-trifluoromethyl-4-nitroanilide 4-Nitro-3-(trifluormethyl)anilin 3-trifluoromethyl-4-nitroaniune 2-Nitro-5-aminobenzotriluoride 5-Amino-2-nitrobenzotrifluoride > Nilutamide impurity B CRS Nilutamide Impurity 3 4-NITRO-3-TRIFLUOROMETHYL ANILINE CAS NO 393-11-3 Flutamide Impurity 1 (Flutamide EP Impurity A) TIANFU-CHEM 4-Nitro-3-trifluoromethyl aniline Flutamide Related Compound A (4-nitro-3-(trifluoromethyl)aniline) (1285997) 4-Nitro-3-Triflouromethyl Aniline (Flutamide Intermediate) Flutamide ImpurityⅠ:4-Nitro-3-(trifluoromethyl)aniline α,α,α-Trifluoro-4-nitro-m-toluidine 4-nitro-3-(trifluoromethyl)benzeneamine Flutamide Impurity A Flutamide USP Related Compound A 4-nitro-3-(trifluoromethyl)aniline (nifeline) Flutamide EP Impurity A(Nilutamide EP Impurity B) 393-11-3 Organic Building Blocks Nitrogen Compounds C7 Amines Building Blocks Anilines, Aromatic Amines and Nitro Compounds Amines Phenyls & Phenyl-Het Phenyls & Phenyl-Het Trifluoromethylbenzene serise Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals