DICHLOROPHENYL-ABA
- CAS No.
- 18201-65-5
- Chemical Name:
- DICHLOROPHENYL-ABA
- Synonyms
- Dichlorophenyl ABA,DichlorophenylABA;benzoic acid, 2-[(3,5-dichlorophenyl)amino]-
- CBNumber:
- CB4503413
- Molecular Formula:
- C13H9Cl2NO2
- Molecular Weight:
- 282.12
- MDL Number:
- MFCD07370135
- MOL File:
- 18201-65-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
DICHLOROPHENYL-ABA price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | HCH0066590 | DICHLOROPHENYL-ABA 95.00% | 18201-65-5 | 5MG | $710.84 | 2021-12-16 | Buy |
| AK Scientific | SYN5506 | DichlorophenylABA | 18201-65-5 | 50mg | $968 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0066590 | DICHLOROPHENYL-ABA 95.00% | 18201-65-5 | 25MG | $1078.14 | 2021-12-16 | Buy |
DICHLOROPHENYL-ABA Chemical Properties,Uses,Production
Biological Activity
Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation and inhibits aggregate formation by more than 80% in cells expressing TTR L55P.
in vitro
Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are.
It is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA -ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity.
target
Transthyretin (TTR) amyloid fibril formation
DICHLOROPHENYL-ABA Preparation Products And Raw materials
Raw materials
Preparation Products
DICHLOROPHENYL-ABA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4249 | 58 |