ChemicalBook >> CAS DataBase List >>DDR1-IN-1 dihydrochloride
DDR1-IN-1 dihydrochloride
- CAS No.
- 1780303-76-5
- Chemical Name:
- DDR1-IN-1 dihydrochloride
- Synonyms
- DDR1-IN-1 dihydrochloride
- CBNumber:
- CB45355404
- Molecular Formula:
- C30H32ClF3N4O3
- Molecular Weight:
- 589.06
- MDL Number:
- MOL File:
- 1780303-76-5.mol
Last updated:2023-06-30 15:45:59
DDR1-IN-1 dihydrochloride Chemical Properties,Uses,Production
Description
DDR1-IN-1 is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the 'DFG-out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion.
storage
Desiccate at RT
DDR1-IN-1 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
DDR1-IN-1 dihydrochloride Suppliers
Global( 6)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4209 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.com | China | 24246 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| BOC Sciences | 65 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| United States Biological | 58 |
DDR1-IN-1 dihydrochloride
1780303-76-5