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ChemicalBook >> CAS DataBase List >>6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Structure
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile structure
CAS No.
2068065-16-5
Chemical Name:
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
Synonyms
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-hydroxy-
CBNumber:
CB45441866
Molecular Formula:
C8H4BrN3O
Molecular Weight:
238.04
MDL Number:
MFCD34182974
MOL File:
2068065-16-5.mol
Last updated:2024-05-22 09:05:03
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6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Properties

Density 1.88±0.1 g/cm3(Predicted)
pka 6.41±0.30(Predicted)
InChI InChI=1S/C8H4BrN3O/c9-6-1-7(13)8-5(2-10)3-11-12(8)4-6/h1,3-4,13H
InChIKey IFUVDUFAFVWZOT-UHFFFAOYSA-N
SMILES C12=C(C#N)C=NN1C=C(Br)C=C2O

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Chemical Properties,Uses,Production

Uses

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile is a pharmaceutical intermediate used in the preparation of Selpercatinib, an FDA-approved drug for the treatment of RET-positive advanced non-small cell lung cancer (NSCLC), thyroid cancer and certain other cancers

Synthesis

At room temperature, add 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (50g, 198.36mmol) and water (16.5mL, 916mmol) in a 1L single-neck flask in sequence, Sodium hydroxide (16.03g, 396.8mmol), DMA (500mL), stirred at room temperature for 5min, then transferred to 0°C, slowly added dodecanethiol (97mL, 397mmol), after the addition, the reaction was moved to 45°C overnight. Pour the reaction solution into 3L ice water, slowly add saturated citric acid water to adjust the PH=5, stir for half an hour, and then stand still filter, wash the filter cake with water and petroleum ether several times, and dry at 60°C to obtain 44.1g of yellow solid 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile (6-Bromo-4-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile).

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Suppliers

Global( 43)Suppliers
Supplier Tel Email Country ProdList Advantage
Xiamen Yunfan Biotech Co.,Ltd.
+8618050056030 yezhaobao@yfpharm.com China 20 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 18219 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
ENBRIDGE PHARMTECH CO., LTD. 		+8613812269233 tinayang@enbridgepharm.com China 303 58
Suzhou Ryan Pharmachem Technology Co.,Ltd. 		+86-512-68780025 +8618962125825 sales@ryanchem.com China 137 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19994 58
Golden Pharma Co., Limited 		+undefined18958062155 sales@zjgoldpharm.com China 5905 58
Meike meditech (Foshan) Co.,Ltd 		+86-0757-22239986 +86-18029359586 sales@mkmeditech.com China 1134 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 11013 58
Supplier Advantage
Xiamen Yunfan Biotech Co.,Ltd.
58
Henan Fengda Chemical Co., Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Shochem(Shanghai) Co.,Ltd 		58
ENBRIDGE PHARMTECH CO., LTD. 		58
Suzhou Ryan Pharmachem Technology Co.,Ltd. 		58
Labnetwork lnc. 		58
Golden Pharma Co., Limited 		58
Meike meditech (Foshan) Co.,Ltd 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58

View Lastest Price from 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile pictures 2024-05-14 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
2068065-16-5
 US $0.00-0.00 / kg 1kg 98% 500Kilogram/Month Xiamen Yunfan Biotech Co.,Ltd.
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile pictures 2024-04-09 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
2068065-16-5
 US $5.00-0.10 / KG 1KG 98% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile pictures 2022-10-09 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
2068065-16-5
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-hydroxy- 2068065-16-5