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Chlorhexidine

Chlorhexidine
Chlorhexidine
CAS No.
55-56-1
Chemical Name:
Chlorhexidine
Synonyms
fimeil;hexadol;soretol;nolvasan;sterilon;rotersept;tubulicid;chlorhexidin;CHLORHEXIDINE;CHLOROHEXIDINE
CBNumber:
CB4732251
Molecular Formula:
C22H30Cl2N10
Formula Weight:
505.45
MOL File:
55-56-1.mol

Chlorhexidine Properties

Melting point:
134-136 °C(lit.)
storage temp. 
Store below +30°C.
solubility 
water: soluble0.08% at 20°C
Water Solubility 
0.08 g/100 mL (20 ºC)
Merck 
13,2108
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
55-56-1(CAS DataBase Reference)
EPA Substance Registry System
2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)- 3,12-diimino-(55-56-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,N
Risk Statements  36/37/38-43-51/53-50/53
Safety Statements  26-36/37-60-61
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS  DU1925000
10-34
HazardClass  9
PackingGroup  III
Hazardous Substances Data 55-56-1(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P284 Wear respiratory protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P501 Dispose of contents/container to..…

Chlorhexidine price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 282227 Chlorhexidine ≥99.5% 55-56-1 1g $91.9 2017-11-08 Buy
Sigma-Aldrich 1111001 Chlorhexidine United States Pharmacopeia (USP) Reference Standard 55-56-1 200mg $342.9 2017-11-08 Buy
Sigma-Aldrich PHR1421 Chlorhexidine Pharmaceutical Secondary Standard; Certified Reference Material 55-56-1 1g $57.4 2017-11-08 Buy
Sigma-Aldrich C1510000 Chlorhexidine European Pharmacopoeia (EP) Reference Standard 55-56-1 1EA $168 2017-11-08 Buy
Sigma-Aldrich 282227 Chlorhexidine ≥99.5% 55-56-1 5g $334.5 2017-11-08 Buy

Chlorhexidine Chemical Properties,Uses,Production

Description

Chlorhexidine is a cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria. It has both bactericidal and bacteriostatic mechanisms of action.
Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
Aqueous solutions of chlorhexidine are most stable within the pH range of 5-8. Above pH 8.0 chlorhexidine base is precipitated and in more acid conditions there is gradual deterioration of activity because the compound is less stable. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. It has a LD-50 orally in mice as a diacetate at 2gm./kg. In digluconate form the LD-50 is 1800 gm./kg.

Chemical Properties

solid

History

Chlorhexidine (CHX) was the first antimicrobial agent shown to inhibit dental plaque formation and the development of chronic gingivitis (Loe and Schiott 1970).
Chlorhexidine is a cationic chlorophenyl bisbiguanide antiseptic.
Bisbiguanides are the primary second generation antiplaque agents exhibiting considerable substantivity and broad spectrum antibacterial properties.
In dental medicine, CHX was initially used for disinfection of the oral cavity prior to oral surgical procedures and in endodontics. Plaque inhibition by CHX was first investigated in 1969 (Schroeder) but the first controlled clinical study was performed by Loe and Schiott (1970). [16] This study showed that rinsing for 60 sec, twice a day with 10 ml of a 0.2% (20 mg dose) CHX gluconate solution, in the absence of normal tooth cleaning, inhibited plaque regrowth and the development of gingivitis.
CHX is one of the most widely investigated and used antiplaque agents.The advantage of CHX over other cationic agents is that it can bind strongly to many sites in the oral cavity and is released slowly over 7 to 12 hours after rinsing, thus providing considerable substantivity and a sustained antimicrobial effect restricting bacterial proliferation. CHX binds strongly with anionic glycoproteins and phosphoproteins on the oral mucosa and tooth pellicle in addition to its property of binding to the surfaces of bacterial cell membranes affecting the cells ability to adhere. CHX is considered the most potent chemotherapeutic agent currently available.

Uses

Chlorhexidine is an antibacterial used for numerous applications. It is a cationic polybiguanide (bisbiguanide) used primarily as its salts, dihydrochloride, diacetate, and digluconate. Chlorhexidine is one of those drugs which are enlisted/included in the World Health Organization's List of Essential Medicines, a list of the most important drugs needed in a basic health system.
  1. Chlorhexidine is used as a germicidal compound in teat dips. Also used as navel treatment, udder and eye wash, surgical scrub and sterilization material.
  2. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. it is used as an antibacterial agent in humans to control gingivitis and over all plaque control in preventative dentistry.
  3. Hydrogenolysis of benzyl-nitrogen bonds.
  4. Bacteriostatic;Detergent.

Definition

ChEBI: A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.

Chlorhexidine Preparation Products And Raw materials

Raw materials

Preparation Products


Chlorhexidine Suppliers

Global( 169)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Ereal Chemical Co., Ltd. +86 18784610518,0831-6888461
QQ:97273224 sales@erealchem.com China 85 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96820 76
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44192 61
Jia Xing Isenchem Co.,Ltd 0573-85280080,15157346371
0573-85285100 isenchem@163.com,QQ:2446116053 China 9600 66
Adamas Reagent, Ltd. 400-600-9262
bxy@titansci.com China 14018 59
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706
+86-21-67220638 chemfun@chemfun.net China 21899 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 20013 64
XiaoGan ShenYuan ChemPharm co,ltd Tell:86-712-2580635 Mobile:15527768850 . 15527768836
86-712-2580625 QQ:1623551145 sales02@farchem.com China 9188 52
China Langchem Inc. 0086-21-58956006,021-38701807;021-58950017
0086-21-58956100 sales@langchem.com China 7892 57

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