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5-Bromo-2-chloropyrimidine

5-Bromo-2-chloropyrimidine structure

CAS No.: 32779-36-5

Chemical Name:: 5-Bromo-2-chloropyrimidine

Synonyms: 2-CHLORO-5-BROMOPYRIMIDINE;2C5BP;5-Bromo-2-chL;Macitentan Impurity 27;5-BROMO-2-CHLOROPYRIMIDNE;Macitentan Intermediate 5;-bromo-2-chloropyrimidine;5-bromo-2-chlorpyrimidine;5-BROMO-2-CHLOROPYRIMIDINE;2-chloro -5-broMo - uracil

CBNumber:: CB4748175

Molecular Formula:: C4H2BrClN2

Molecular Weight:: 193.43

MDL Number:: MFCD00483232

MOL File:: 32779-36-5.mol

MSDS File:: SDS

Last updated:2024-04-24 17:21:45

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5-Bromo-2-chloropyrimidine Properties

Melting point	73-79 °C (lit.)
Boiling point	95°C 15mm
Density	1.859±0.06 g/cm3(Predicted)
Flash point	95°C/15mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	-2.84±0.22(Predicted)
form	Crystalline Powder
color	Off-white to beige
Water Solubility	insoluble
BRN	507955
Stability	Hygroscopic
InChI	InChI=1S/C4H2BrClN2/c5-3-1-7-4(6)8-2-3/h1-2H
InChIKey	XPGIBDJXEVAVTO-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(Br)C=N1
CAS DataBase Reference	32779-36-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/39-37/39-36

RIDADR

UN 3335

WGK Germany

HazardClass

IRRITANT

HS Code

29335990

NFPA 704

	1
2		0

5-Bromo-2-chloropyrimidine price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	596949	5-Bromo-2-chloropyrimidine 96%	32779-36-5	1g	$10.64	2024-03-01	Buy
TCI Chemical	B2847	5-Bromo-2-chloropyrimidine >97.0%(GC)	32779-36-5	1g	$18	2024-03-01	Buy
TCI Chemical	B2847	5-Bromo-2-chloropyrimidine >97.0%(GC)	32779-36-5	5g	$26	2024-03-01	Buy
Alfa Aesar	L18360	5-Bromo-2-chloropyrimidine, 98+%	32779-36-5	5g	$109.65	2024-03-01	Buy
Alfa Aesar	L18360	5-Bromo-2-chloropyrimidine, 98+%	32779-36-5	1g	$31.6	2022-04-27	Buy

Product number	Packaging	Price	Buy
596949	1g	$10.64	Buy
B2847	1g	$18	Buy
B2847	5g	$26	Buy
L18360	5g	$109.65	Buy
L18360	1g	$31.6	Buy

5-Bromo-2-chloropyrimidine Chemical Properties,Uses,Production

Chemical Properties

Off-white to beige crystalline powder

Uses

5-Bromo-2-chloropyrimidine is applied as a pharmaceutical intermediate, in the synthesis of pharmaceutical goods such as inhibitors. It is also employed in the cross-coupling reactions of indium organometallics with 2,5-dihalopyrimidines.

Uses

5-Bromo-2-chloropyrimidine is a intermediate in the synthesis of pharmaceutical goods such as inhibitors.

Preparation

Under nitrogen protection, 35 g (0.2 mol) of 2-hydroxy-5-bromopyrimidine, 61.3 g (0.4 mol) of phosphorus oxychloride, and 200 mL of toluene were added into the reaction flask. At 35 ℃, triethylamine 40.5g was added and then heated up at 80-85 ℃. Stir the reaction for 6 hours, sampling HPLC to detect the raw material (less than 2%), and lower the temperature. After concentrating the mixture under reduced pressure to remove most of the toluene and Phosphorus oxychloride, put the reaction solution into 10°C water, and adjust pH=8-9 with 20% sodium carbonate aqueous solution. Finally, 5-Bromo-2-chloropyrimidine was obtained after purification.

Reactivity Profile

5-Bromo-2-chloropyrimidine, a 2,5-dihalopyrimidine, is a useful organic electrophiles. It could react with tri(3-indolyl)indium reagent through cross-coupling reaction. Other aryl- and heteroarylindium reagents, such as thiophenyl-, pyridyl-, naphthyl-, and alkynylindium reagents, also reacted with 5-bromo-2- chloropyrimidine to afford the corresponding 2-chloro-5-substituted pyrimidines[1].
5-Bromo-2-chloropyrimidine

References

[1] Mosquera A, et al. Cross-Coupling Reactions of Indium Organometallics with 2,5-Dihalopyrimidines: Synthesis of Hyrtinadine A?. Organic Letters, 2008; 10: 3745–3748.

5-Bromo-2-chloropyrimidine synthesis

Synthesis of 5-Bromo-2-chloropyrimidine from 5-Bromo-2-hydroxypyrimidine

5-Bromo-2-chloropyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

5-BROMO-2-ETHOXY-PYRIMIDINE 5-Bromopyrimidine-2-carbonitrile 5-BROMO-2-(DIMETHYLAMINO)PYRIMIDINE 5-BROMOPYRIMIDINE-2-CARBOXYLIC ACID (5-BROMO-PYRIMIDIN-2-YL)-DIETHYL-AMINE

5-BROMO-2-(METHYLAMINO)PYRIMIDINE 2-CHLOROPYRIMIDINE-5-BORONIC ACID 5-BROMO-2-(PYRROLIDIN-1-YL)PYRIMIDINE 2-CHLORO-5-PHENYL-PYRIMIDINE 2-Chloropyrimidine-5-carbaldehyde

5-Bromo-2-methoxypyrimidine Tert-Butyl Methyl 2-(5-Bromopyrimidin-2-Yl)Malonate N-(5-BroMopyriMidin-2-yl)-N-MethylacetaMide

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5-Bromo-2-chloropyrimidine Suppliers

Global( 734)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou Fullone Chemical Co., Ltd.	+86-13328197671 +86-13861172460	sales@borenchem.cn	China	1055	58
Shenyang TYSChem Co., Ltd.	+86-24-83607930 +8618640359690	sales@honghuchem.com	China	403	58
Changzhou Chontech Baocheng Chemical Co.,Ltd	+86-51982698291; +undefined15295095616	info@hhbhswkj.com	China	73	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Seasons Biotechnology Co., Ltd.	+86-0576-89232655 +86-13566878689	info@seasonsbio.com	China	46	58
ChemExpress	+86-021-58950125	info@chemexpress.com	China	557	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2259	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	885	50
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60

Supplier	Advantage
Changzhou Fullone Chemical Co., Ltd.	58
Shenyang TYSChem Co., Ltd.	58
Changzhou Chontech Baocheng Chemical Co.,Ltd	58
Changzhou Rokechem Technology Co., Ltd.	58
Seasons Biotechnology Co., Ltd.	58
ChemExpress	58
Henan Fengda Chemical Co., Ltd	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60

View Lastest Price from 5-Bromo-2-chloropyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	5-Bromo-2-chloropyrimidine 32779-36-5	US $5.00 / kg	1kg	99.92%	50000tons	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-01-11	5-Bromo-2-chloropyrimidine 32779-36-5	US $122.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-07-19	5-Bromo-2-chloropyrimidine 32779-36-5	US $30.00 / KG	1KG	99%	20 Tons	Wuhan wingroup Pharmaceutical Co., Ltd

5-Bromo-2-chloropyrimidine
32779-36-5
US $5.00 / kg
99.92%
Ouhuang Engineering Materials (Hubei) Co., Ltd

5-Bromo-2-chloropyrimidine
32779-36-5
US $122.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

5-Bromo-2-chloropyrimidine
32779-36-5
US $30.00 / KG
99%
Wuhan wingroup Pharmaceutical Co., Ltd

5-Bromo-2-chloropyrimidine Spectrum

5-Bromo-2-chloropyrimidine(32779-36-5)MS 5-Bromo-2-chloropyrimidine(32779-36-5)¹HNMR 5-Bromo-2-chloropyrimidine(32779-36-5)¹³CNMR 5-Bromo-2-chloropyrimidine(32779-36-5)IR1 5-Bromo-2-chloropyrimidine(32779-36-5)IR2

32779-36-5(5-Bromo-2-chloropyrimidine)Related Search:

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PYRIMIDINE, 5-BROMO-2-CHLORO- 2-chloro-5-broMopyriMidine(5-broMo-2-chloropyriMidine) 2-chloro -5-broMo - uracil 5 - broMine - 2 - chloro pyriMidine 5-methyl-4,5-dihydrothiazol-2-amine 5-BROMO-2-CHLOROPYRIMIDINE 5-BROMO-2-CHLOROPYRIMIDNE 5-BROMO-2-CHLOROPYRIMIDINE(MINIMUM85%) 5-Bromo-2-chloropyrimidine 85% 2C5BP 5-Bromo-2-chloropyrimidine, 98+% 5-Bromo-2-chloropyrimidine,96% 5-Bromo-2-chloro-1,3-diazine Macitentan Intermediate 5 Macitentan Impurity 27 5-Bromo-2-chL e 5-Bromo-2-chloropyrimidine 5-Bromo-2-chloropyrimidine > -bromo-2-chloropyrimidine 5-bromo-2-chlorpyrimidine 5-broMine-2-chChemicalbookloropyriMidine 2-CHLORO-5-BROMOPYRIMIDINE 5-BROMO-2-CHLOROPYRIMIDINE(MINIMUM95%) MAJORIMPURITYIS2,5-DIBROMOPYRIMIDINE 5-Bromo-2-Chloropyrimidine (Intermediate of Masetitan) Macitentan Impurity 27 CRS 5-Bromo-2-chloropyrimidine2C5BP 32779-36-5 32799-36-5 C4H2BrClN2 C4H2ClBrN2 C4H2BrCIN2 C4H2N2BrCl Building Blocks Pyrimidines Heterocyclic Building Blocks Halogenated Heterocycles Pyridines, Pyrimidines, Purines and Pteredines pharmacetical Pyrazines, Pyrimidines & Pyridazines Pyrimidine Pyrimidine Series Halides Heterocycles Pyrazines, Pyrimidines & Pyridazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PyrimidinesHeterocyclic Building Blocks Variety of halogenated heterocyclic series Halogenated Organohalides Heterocycle-Pyrimidine series Pharmaceutical intermediates Thiophenes Building Blocks C4 to C5