4-HYDROXY PROPRANOLOL HCL
- CAS No.
- 14133-90-5
- Chemical Name:
- 4-HYDROXY PROPRANOLOL HCL
- Synonyms
- Propranolol Impurity 10;4-HYDROXY PROPRANOLOL HCL;rac-4-Hydroxy Propranolol HCl;Propranolol 4-Hydroxy Impurity;4-Hydroxy Propranolol HCl (Rac);(±)-4-Hydroxypropranolol-d7 HCl;4-HYDROXYPROPRANOLOL HYDROCHLORIDE;(R)-4-Hydroxy Propranolol Hydrochloride;(S)-4-Hydroxy Propranolol Hydrochloride;rac-4-Hydroxy Propranolol Hydrochloride
- CBNumber:
- CB4752444
- Molecular Formula:
- C16H21NO3.ClH
- Molecular Weight:
- 311.8
- MDL Number:
- MFCD06656370
- MOL File:
- 14133-90-5.mol
4-HYDROXY PROPRANOLOL HCL price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 18630 | (±)-4-hydroxy Propranolol (hydrochloride) ≥95% | 14133-90-5 | 1mg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 18630 | (±)-4-hydroxy Propranolol (hydrochloride) ≥95% | 14133-90-5 | 5mg | $202 | 2024-03-01 | Buy |
Cayman Chemical | 18630 | (±)-4-hydroxy Propranolol (hydrochloride) ≥95% | 14133-90-5 | 10mg | $363 | 2024-03-01 | Buy |
TRC | H952545 | rac-4-HydroxyPropranololHydrochloride | 14133-90-5 | 5mg | $185 | 2021-12-16 | Buy |
TRC | H952545 | rac-4-HydroxyPropranololHydrochloride | 14133-90-5 | 50mg | $1455 | 2021-12-16 | Buy |
4-HYDROXY PROPRANOLOL HCL Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A metabolite of Propranolol.
Uses
The main metabolite of (S)-Propranolol
Uses
The main metabolite of (R)-Propranolol
Biological Activity
(±)-4-hydroxy propranolol, an active metabolite of propranolol, blocks β1- and β2-adrenergic receptors (β1-ars, β2-ars). also, (±)-4-hydroxy propranolol has antioxidant properties at micromolar concentrations. β1- and β2-ars, expressed in cardiac myocytes, mediate an increase in contractility by gs-dependent coupling to adenylyl cyclase.
in vitro
compared to the control, (±)-4-hydroxy propranolol potently blocked the lipid peroxidation in a concentration-dependent fashion in endothelial cells. when pretreated with (±)-4-hydroxy propranolol at 0.067 to 6.7 μm, the degrees of protection were increased against the glutathione loss in the endothelial cells. additionally, (±)-4-hydroxy propranolol effectively preserved the loss of cell survival because of the radical stress [1].
in vivo
rats were injected intravenously with (±)-4-hydroxy propranolol into the femoral vein at 0.1 ml/100 g. (±)-4-hydroxy propranolol induced an increase in heart rate in a dose-dependent manner in rats depleted of catecholamines, which suggested that (±)-4-hydroxy propranolol had intrinsic sympathomimetic activity. the response of (±)-4-hydroxy propranolol was inhibited when rats were pretreated with 0.5 mg/kg propranolol [2].
IC 50
1.1 μm: inhibits lipid peroxidation in endothelial cells.
References
[1]. mak, i. potent antioxidant properties of 4-hydroxyl-propranolol. journal of pharmacology and experimental therapeutics. 2003; 308(1): 85-90.
[2]. fitzgerald, j., & o'donnell, s. pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. british journal of pharmacology. 1971; 43(1): 222-235.
4-HYDROXY PROPRANOLOL HCL Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |