ChemicalBook >> CAS DataBase List >>Tacrolimus Monohydrate
Tacrolimus Monohydrate
- CAS No.
- 109581-93-3
- Chemical Name:
- Tacrolimus Monohydrate
- Synonyms
- Tacrolimus monohydrate;FK-506;135175;CS-1308;Tacarolimus;[3R[E(1S,3S,4S);tacrolimushydrate;FK-506 MONOHYDRATE;Tacrolimus (150 mg);FR900506 monohydrate
- CBNumber:
- CB4772400
- Molecular Formula:
- C44H71NO13
- Molecular Weight:
- 822.05
- MDL Number:
- MFCD11045918
- MOL File:
- 109581-93-3.mol
- MSDS File:
- SDS
Last updated:2023-07-13 17:52:38
| Melting point | 127-129° |
|---|---|
| alpha | D23 -84.4° (c = 1.02 in chloroform) |
| storage temp. | -20°C |
| solubility | DMSO: soluble20mg/mL |
| form | powder |
| color | White to Almost white |
| Merck | 14,9025 |
| InChIKey | NWJQLQGQZSIBAF-MLAUYUEBSA-N |
| FDA UNII | WM0HAQ4WNM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KD4201200 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2934990002 | |||||||||
| Toxicity | LD50 i.p. in mice: >200 mg/kg (Kino); LD50 in male, female rats (mg/kg): 57.0, 23.6 i.v.; 134, 194 orally (Ohara) | |||||||||
| NFPA 704 |
|
Tacrolimus Monohydrate price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001926 | Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | Y0001926 | $601 | 2024-03-01 | Buy |
| Sigma-Aldrich | F4679 | FK-506 monohydrate ≥98% (HPLC) | 109581-93-3 | 5mg | $271 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1642802 | Tacrolimus United States Pharmacopeia (USP) Reference Standard | 109581-93-3 | 100MG | $1480 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1642802 | Tacrolimus United States Pharmacopeia (USP) Reference Standard | 109581-93-3 | 150mg | $1590 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0001933 | Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | Y0001933 | $212 | 2023-06-20 | Buy |
Tacrolimus Monohydrate Chemical Properties,Uses,Production
Uses
immune suppressant, antifungal
Uses
FK-506 monohydrate has been used:
- as an immunosuppressive agent in coculture medium to study the effect of immunologic reaction
- as a calcineurin inhibitor, in anhydrous Me2SO solution
- to treat retinal pigment epithelial cells to measure possible cytotoxicity
Definition
ChEBI: A hydrate that is the monohydrate form of tacrolimus.
Biological Activity
Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo .
Biochem/physiol Actions
FK-506 also appears to inhibit Na+/Ca2+ exchange. FK-506 and its derivatives demonstrate significant neurodegenerative activity. This property seems to arise via different mechanisms. FK-506 is also useful in treating ophthalmologic complications such as corneal graft rejection, uveoretinitis and allergen induced conjunctivitis.
Safety Profile
A poison by ingestion and intravenous routes. When heated to decomposition it emits toxic vapors of NOx.
Tacrolimus Monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 246)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Mesochem Technology Co.,Ltd | +8613651027935 | rachel@mesochem.com | China | 191 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from Tacrolimus Monohydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-08 | Tacrolimus Monohydrate
109581-93-3
|
US $30.00-25.00 / KG | 1KG | 99.50% | 20tons | Wuhan Boyuan Import & Export Co., LTD | |
 |
2023-08-16 | Tacrolimus
109581-93-3
|
US $50.00 / KG | 1KG | >99% | 20tons | Weijer International Trade (Hebei) Co., Ltd | |
 |
2022-09-21 | Tacrolimus
109581-93-3
|
US $120.00 / G | 1G | 99% | Ex 20 tons | Hebei Anda Technology Co., LTD |
-
- Tacrolimus Monohydrate
109581-93-3
- US $30.00-25.00 / KG
- 99.50%
- Wuhan Boyuan Import & Export Co., LTD
-
- Tacrolimus
109581-93-3
- US $50.00 / KG
- >99%
- Weijer International Trade (Hebei) Co., Ltd
-
- Tacrolimus
109581-93-3
- US $120.00 / G
- 99%
- Hebei Anda Technology Co., LTD
109581-93-3(Tacrolimus Monohydrate)Related Search:
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
TACROLIMUS HYDRATE/TSUKUBAENOLIDE HYDRATE
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
Tacrolimus (150 mg)
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-Methoxycyclohexyl]-1-Methylethenyl]-14,16-diMethoxy-4,10,12,18-tetraMethyl-8-(2-propen-1-yl)-
FK-506 monohydrate, >=98%
Tacrolimus /FK506 monohydrate
,8s*,9e,12r*,14r*,15s*,16r*,18s*,19s*,26ar*))-
18-tetramethyl-8-(2-propenyl)-,monohydrate,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*
3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-9,10,12,
tacrolimushydrate
tsukubaenolidehydrate
FK-506 MONOHYDRATE
Tacarolimus
15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-te
Tacrolimus Monohydrate CAS 109581-93-3
FK506 Monohydrate[Tacrolimus Hydrate]
135175
CS-1308
FK 506 monohydrate, Tacrolimus
Tacrolimus monohydroate
TacrolimusMonohydrate>
Tacrolimus monohydrate CRS
FR900506 monohydrate
Tacrolimus monohydrate (Fujimycin monohydrate
[3R[E(1S,3S,4S)
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate
Tacrolimus monohydrate (Y0001926)
Tacrolimus (1642802)
FK-506
Tacrolimus monohydrate
Lecithin Impurity 9 (L-α-Phosphatidylinositol)
Tacrolimus USP/IP/PH.Eur
Tacrolimus Reference Standard
109581-93-3
C44H69NO12H2O
Cell Signaling and Neuroscience
Kinase/Phosphatase Biology
Protein Phosphatase 2B (Calcineurin/PP2B)
Serine/Threonine Phosphatase Inhibitors
BioChemical
Cell Biology
Signalling