Fluorinated VHL spy molecule 3

CAS No.
2290526-29-1
Chemical Name:
Fluorinated VHL spy molecule 3
Synonyms
Fluorinated VHL spy molecule 3;(2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide;2-Pyrrolidinecarboxamide, 4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-1-(2,2,2-trifluoroacetyl)-, (2S,4R)-
CBNumber:
CB48362274
Molecular Formula:
C18H18F3N3O3S
Molecular Weight:
413.41
MDL Number:
MOL File:
2290526-29-1.mol
MSDS File:
SDS

Fluorinated VHL spy molecule 3 Properties

Boiling point 674.0±55.0 °C(Predicted)
Density 1.428±0.06 g/cm3(Predicted)
pka 13.59±0.40(Predicted)

Fluorinated VHL spy molecule 3 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 909440 Fluorinated VHL spy molecule 3 ≥95% 2290526-29-1 10mg $120 2023-06-20 Buy
Sigma-Aldrich 909440 Fluorinated VHL spy molecule 3 ≥95% 2290526-29-1 100mg $688 2023-06-20 Buy
Product number Packaging Price Buy
909440 10mg $120 Buy
909440 100mg $688 Buy

Fluorinated VHL spy molecule 3 Chemical Properties,Uses,Production

Uses

Fluorinated VHL Spy Molecule 3 can be used for the discovery of new von Hippel-Lindau (VHL) binders. Based on VH032 (cat# 901490), this reporter was designed in the lab of Alessio Ciulli to bind the hydroxyproline (Hyp) recognition site of VHL. When used in competition ligand-observed 19F NMR screening experiments, its displacement indicates binding by another molecule. Additional Fluorinated VHL Spy Molecules are available as listings 909416, 909432, and 909459.
The E3 ligase VHL is of growing interest for targeted protein degradation, and these spy molecules will facilitate the identification of novel VHL ligands and VHL-based degraders.

Fluorinated VHL spy molecule 3 Preparation Products And Raw materials

Raw materials

Preparation Products

Fluorinated VHL spy molecule 3 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific
+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9779 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1350 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18488 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 market@aladdin-e.com China 48467 58
Fluorinated VHL spy molecule 3 2-Pyrrolidinecarboxamide, 4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-1-(2,2,2-trifluoroacetyl)-, (2S,4R)- (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide 2290526-29-1