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Dasatinib monohydrate

Dasatinib monohydrate Structure
Dasatinib monohydrate structure
CAS No.
863127-77-9
Chemical Name:
Dasatinib monohydrate
Synonyms
Sprycel;Dasatinib hydrate;mmbf;CS-295;Dastinib;Dasatinib R;Bms 35482503;Unii-rbz1571X5h;Dasatinib(TINIBS);Dasatinib(Sprycel)
CBNumber:
CB4844484
Molecular Formula:
C22H28ClN7O3S
Molecular Weight:
506.02
MDL Number:
MFCD08704581
MOL File:
863127-77-9.mol
MSDS File:
SDS
Last updated:2024-04-15 15:30:59
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Dasatinib monohydrate Properties

Melting point >223° (dec.)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form Solid
color White to Off-White
Stability Hygroscopic
InChIKey XHXFZZNHDVTMLI-UHFFFAOYSA-N
SMILES N(C1=NC=C(C(=O)NC2C(=CC=CC=2C)Cl)S1)C1N=C(C)N=C(N2CCN(CCO)CC2)C=1.O
CAS DataBase Reference 863127-77-9(CAS DataBase Reference)
FDA UNII RBZ1571X5H
NCI Dictionary of Cancer Terms Sprycel
NCI Drug Dictionary Sprycel

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS08,GHS09,GHS06
Signal word  Danger
Hazard statements  H410-H300-H372-H361-H360
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P314-P501-P273-P391-P501-P201-P202-P281-P308+P313-P405-P501
HS Code  29339900

Dasatinib monohydrate price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D193638 DasatinibMonohydrate 863127-77-9 250mg $50 2021-12-16 Buy
TRC D193638 DasatinibMonohydrate 863127-77-9 500mg $80 2021-12-16 Buy
Biosynth Carbosynth FD10821 Dasatinib monohydrate 863127-77-9 500mg $80 2021-12-16 Buy
ApexBio Technology B5954 DasatinibMonohydrate 863127-77-9 500mg $95 2021-12-16 Buy
Biosynth Carbosynth BD164354 Dasatinib monohydrate 863127-77-9 100mg $50 2021-12-16 Buy
Product number Packaging Price Buy
D193638 250mg $50 Buy
D193638 500mg $80 Buy
FD10821 500mg $80 Buy
B5954 500mg $95 Buy
BD164354 100mg $50 Buy

Dasatinib monohydrate Chemical Properties,Uses,Production

Uses

antineoplastic

Uses

Dasatinib Monohydrate is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. It is a COVID19-related research product.

Definition

Dasatinib monohydrate is a hydrate that is the monohydrate of dasatinib. It is used for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN； dasatinib monohydrate) as well as to anhydrous dasatinib (INN). It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It contains a dasatinib (anhydrous).

brand name

Sprycel (Bristol-Myers Squibb).

Biological Activity

chronic myeloid leukemia (cml) is a disease characterized by the presence of the philadelphia (ph+) chromosome and its oncogenic product, bcr-abl, that is present in >90% of the patients. dasatinib (bms-354825) is a novel, potent, and multitargeted kinase inhibitor that targets abl, src, kit, pdgfr, and other tyrosine kinases.

in vitro

dasatinib is a potent atp-competitive inhibitor in biochemical assays with broad-spectrum antiproliferative activities against hematological and solid tumor cell lines. dasatinib was more potent than imatinib at inhibiting nonmutated bcr-abl kinase activity. in addition, the kinase activity of 14 out of 15 different clinically relevant, imatinib-resistant bcr-abl isoforms was successfully inhibited [1].

in vivo

mice were dosed with dasatinib or vehicle alone by gavage for 2 weeks, beginning 3 days after injection of ba/f3 cells. all vehicle-treated mice developed progressive disease. in contrast, dasatinib–treated mice harboring nonmutant bcr-abl or the clinically common imatinib-resistant mutation m351t appeared healthy with no evidence of weight loss, lethargy, or ruffled fur and showed more than one log lower levels of bioluminescent activity after 2 weeks of therapy [2].

IC 50

0.55 and 3.0 nm for src and bcr-abl tyrosine kinases, respectively

References

[1] shah np, tran c, lee fy, chen p, norris d, sawyers cl. overriding imatinib resistance with a novel abl kinase inhibitor. science. 2004 jul 16;305(5682):399-401.
[2] monika conchon, carla maria boquimpani de moura freitas, maria aparecida do carmo rego, and josé wilson ramos braga junior. dasatinib -

Dasatinib monohydrate synthesis

302962-49-8
863127-77-9
Synthesis of Dasatinib monohydrate from Dasatinib

Dasatinib monohydrate Preparation Products And Raw materials

Raw materials

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide N-Deshydroxyethyl Dasatinib Dasatinib 4,6-Dichloro-2-methylpyrimidine
Dasatinib

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Preparation Products

Dasatinib monohydrate Suppliers

Global( 438)Suppliers
Supplier Tel Email Country ProdList Advantage
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
+86-0531-69954981 +8615666777973 dwyane.wang@boyuanpharm.com China 211 58
shandong perfect biotechnology co.ltd 		+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 7377 58
Wuhan Xinhao Biotechnology Co., Ltd 		+86-18120578002 +86-18120578002 xinhao-6@xinhaoshengwu.com China 350 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+86-13474506593 +86-13474506593 sarah@tnjone.com China 794 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Shanghai Bojing Chemical Co.,Ltd. 		+86-86-02137122233 +8613795318958 bj1@bj-chem.com China 298 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
Supplier Advantage
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
58
shandong perfect biotechnology co.ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Wuhan Xinhao Biotechnology Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Shanghai Bojing Chemical Co.,Ltd. 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55

Related articles

View Lastest Price from Dasatinib monohydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dasatinib monohydrate pictures 2024-04-15 Dasatinib monohydrate
863127-77-9
 US $32.00-1.30 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
Dasatinib monohydrate pictures 2024-04-13 Dasatinib monohydrate
863127-77-9
 US $0.00 / kg 1kg 99% 10000kg Shaanxi TNJONE Pharmaceutical Co., Ltd
Dasatinib monohydrate pictures 2024-04-02 Dasatinib monohydrate
863127-77-9
 US $10.00-100.00 / kg 1kg 99% 100 tons Wuhan Xinhao Biotechnology Co., Ltd

Dasatinib monohydrate Spectrum

Dasatinib monohydrate(863127-77-9)1HNMR

863127-77-9(Dasatinib monohydrate)Related Search:

Erlotinib Teniposide 2-(METHYLSULFONYL)ETHANOL Gefitinib Lapatinib
Sunitinib 2-Ethylhexyl ferulate N-Aminoethylpiperazine MELIBIOSE Imatinib
3,4'-DIAMINODIPHENYLMETHANE Dasatinib N-O impurity Dasatinib impurity 28 Dasatinib impurity 29 Epichlorohydrin
Dasatinib Chloroacetic acid Difluorochloromethane

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Dasatinib R BMS-354825 Monohydrate N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide hydrate Dasatinib monohydrate N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate Dasatinib monohydrate, >=99% dasatinib monohydrate 5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-, hydrate (1:1) Dasatinib(TINIBS) Dastinib Bms 35482503 Unii-rbz1571X5h n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide monohydrate n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2- CS-295 Dasatinib(Sprycel) N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide,hydrate asatinib monohydrate Dasatinib monohydrate USP/EP/BP DasatinibmonohydrateDasatinib Dasatinib Monohydrate (BMS354825 Dasatinib Monohydrate intermediate Dasatinib hydrate Sprycel mmbf Dashatini monohydrate Dasatinib (monohydrate) (Dasatinib Impurity) Dashatinib monohydrate 863127-77-9 863121-77-9 C22H26CIN7O2SH2O C22H26ClN7O2SH2O Inhibitors API Anti-cancer&immunity SPRYCEL Molecular Targeted Antineoplastic Pharmaceutical 863127-77-9