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N,N-Diisopropylethylamine

CAS No.
7087-68-5
Chemical Name:
N,N-Diisopropylethylamine
Synonyms
DIPEA;DIEA;DIISOPROPYLETHYLAMINE;N-Ethyl-N,N-diisopropylamine;N-Ethyl-N-isopropylpropan-2-aMine;ETHYLDIISOPROPYLAMINE;N-ETHYLDIISOPROPYLAMINE;HUNIGS BASE;DIEA EthyldiisopropylaMine;N,N-DIISOPROPYLETHYLAMINE (DIPEA)
CBNumber:
CB4854144
Molecular Formula:
C8H19N
Molecular Weight:
129.24
MDL Number:
MFCD00008868
MOL File:
7087-68-5.mol
MSDS File:
SDS
Last updated:2023-08-23 18:01:39

N,N-Diisopropylethylamine Properties

Melting point <-50 °C (lit.)
Boiling point 127 °C (lit.)
Density 0.742 g/mL at 25 °C (lit.)
vapor pressure 31 mmHg ( 37.7 °C)
refractive index n20/D 1.457
Flash point 6 °C
storage temp. Store below +30°C.
solubility miscible
pka 10.98±0.28(Predicted)
form Liquid
Specific Gravity 0.755 (20/4℃)
color APHA: <20
PH 12.3 (H2O, 20℃)(as an emulsion)
explosive limit 0.7-6.3%(V)
Water Solubility miscible
BRN 605301
Stability Volatile
InChIKey JGFZNNIVVJXRND-UHFFFAOYSA-N
LogP -1.8 at 22.5℃
CAS DataBase Reference 7087-68-5(CAS DataBase Reference)
FDA UNII 5SIQ15721L
NIST Chemistry Reference (i-C3H7)2(C2H5)N(7087-68-5)
EPA Substance Registry System 2-Propanamine, N-ethyl-N-(1-methylethyl)- (7087-68-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H225-H302-H318-H331-H335-H411
Precautionary statements  P210-P273-P280-P301+P312-P304+P340+P311-P305+P351+P338
Hazard Codes  C,F,T
Risk Statements  11-22-34-52/53-20/21/22-10-41-37/38-20/22-36/37/38-61
Safety Statements  26-36/37/39-45-61-16-27-60-23-9-53
RIDADR  UN 2734 8/PG 2
WGK Germany  2
9-34
Autoignition Temperature 240 °C
Hazard Note  Highly Flammable/Corrosive/Harmful
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29211980
Toxicity LD50 orally in Rabbit: > 200 - 500 mg/kg
NFPA 704
3
3 0

N,N-Diisopropylethylamine price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.00894 N-Ethyldiisopropylamine for synthesis 7087-68-5 100mL $61.4 2024-03-01 Buy
Sigma-Aldrich 8.00894 N-Ethyldiisopropylamine for synthesis 7087-68-5 250ML $66 2024-03-01 Buy
Sigma-Aldrich 8.00894 N-Ethyldiisopropylamine for synthesis 7087-68-5 1L $166 2024-03-01 Buy
Sigma-Aldrich 8.00894 N-Ethyldiisopropylamine for synthesis 7087-68-5 19kg $1140 2024-03-01 Buy
Sigma-Aldrich 03440 N-Ethyldiisopropylamine BASF quality, ≥98.0% 7087-68-5 1l $373 2024-03-01 Buy
Product number Packaging Price Buy
8.00894 100mL $61.4 Buy
8.00894 250ML $66 Buy
8.00894 1L $166 Buy
8.00894 19kg $1140 Buy
03440 1l $373 Buy

N,N-Diisopropylethylamine Chemical Properties,Uses,Production

Description

N,N-Diisopropylethylamine is also known as Hunig's base and abbreviated as DIPEA or DIEA, It is a sterically hindered amine and an organic compound. The colourless liquid was named as Hung’s base after Siegfried Hunig, a German chemist. It is noteworthy that the compound is commercially available.
In organic chemistry, N,N-Diisopropylethylamine is used as a base. Since the nitrogen centre is isolated by an ethyl group and the two isopropyl groups, It can bind to protons. The compound is, therefore, a base similar to 2,2,6,6-tetramethylpiperidine, but a poor nucleophile, a blend of properties that makes it valuable as an organic reagent.

Stability and Reactivity

DIPEA exhibits violent reaction as well as flammability with nitrates, oxidizing agents, and peroxides.
It can also react very exothermically and possibility of spitting with halogens and strong acids. In an alkaline environment, the compound is likely to react violently. In addition, the compound can form toxic products such as n-nitrosamines when combined with nitrous acid as well as oxygen, nitrosating agents, and nitrates.
Under normal conditions (temperature and pressure), DIPEA is very stable. However, it is soluble in most organic solvents.

Applications

N,N-Diisopropylethylamine is utilized as a base in the palladium(0)catalysed alkoxycarbonylation of both allyl acetates and phosphates. It is used as a neutralizer of the produced phosphoric acid. Notably, the alkyl ester cannot be produced without DIPEA.
When combined with boryl triflates, N,N-Diisopropylethylamine is used in the enolate synthesis of ketones for application in directed cross-adol reactions.
DIPEA is applied as a proton scavenger in organic synthesis. Since the compound is a sterically hindered amine, it lacks quaternization; therefore, making it a perfect choice of a base for use with extremely reactive alkylating agents. DIPEA is specifically useful as a base in the protection of alcohols as substituted ethers in the field of protecting group chemistry.
In the synthesis of peptides, the compound is also used in the coupling of amino acids. The steric nature and basicity of DIPEA during the coupling reaction affects the degree of racemization.

Chemical Properties

Diisopropylethylamine (DIPEA) is a clear, colorless to light yellow liquid, insoluble in water and easily soluble in acetone and other organic solvents.

Uses

N,N-Diisopropylethylamine is used as a base in organic reactions. Used in the preparation of (-)Gambierol a marine polycyclic ether toxin. It is also used in the synthesis of potent inhibitors of human brain memapsin, a key effector in the progression of Alzheimer’s disease.

Application

N,N-Diisopropylethylamine is an important pesticide and pharmaceutical intermediate, which can be used to synthesize anesthetics and herbicides, and can also be used as a sterically hindered amine to participate in various catalytic reactions.

Preparation

N,N-Diisopropylethylamine is used as a non-nucleophilic base in organic synthesis. It is prepared by the alkylation of diisopropylamine with diethyl sulphate. DIPEA can then be purified through distillation from potassium hydroxide if necessary.

Definition

ChEBI: N,N-Diisopropylethylamine (DIPEA) is a tertiary amino compound.

General Description

N-Ethyldiisopropylamine (EDIA) reacts with monoactivated Michael acceptors to afford symmetrical sulfones.

Flammability and Explosibility

Highly flammable

Purification Methods

Distil the amine from ninhydrin, then from KOH [Dryland & Sheppard, J Chem Soc, Faraday Trans 1 125 1986]. It is a strong base and should be stored in the absence of carbon dioxide. [Hünig & Kiessel Chem Ber 91 380, 387 1958, Wotiz et al. J Org Chem 24 1202 1959, Beilstein 4 IV 551.]

56-34-8
108-18-9
7087-68-5
Synthesis of N,N-Diisopropylethylamine from Tetraethylammonium Chloride and Diisopropylamine

N,N-Diisopropylethylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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  • Jun 29,2020

View Lastest Price from N,N-Diisopropylethylamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N,N-Diisopropylethylamine pictures 2024-03-29 N,N-Diisopropylethylamine
7087-68-5
US $0.00 / Kg/Drum 1KG 99% 500mt Jinan Finer Chemical Co., Ltd
DIEA pictures 2024-01-12 DIEA
7087-68-5
US $1.00-100.00 / mg 100mg 0.99 5ton/month ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
N,N-Diisopropylethylamine pictures 2023-09-06 N,N-Diisopropylethylamine
7087-68-5
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
  • DIEA pictures
  • DIEA
    7087-68-5
  • US $1.00-100.00 / mg
  • 0.99
  • ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD
N N-DIISOPROPYLETHYLAMINE (ATOFINA ED& N N-DIISOPROPYLETHYLAMINE REAGENTPLUS(& N,N-DIISOPROPYLETHYLAMINE, BIOTECH GRADE SOLVENT, 99.5% N-ETHYLDIISOPROPYLAMINE, 4X25 ML VIALS N,N-Di-#niso-propylethylamine N N-DIISOPROPYLETHYLAMINE BIOTECH GRAD& N N-DIISOPROPYLETHYLAMINE REDISTILLED & N,N-DIISOPROPYLETHYLAMINE, REDISTILLED, 99.5% HUENIG'S BASE 'HUNIG'S BASE' Hunig’sreagent N,N-Diisopropyl-ethylamin DIEA/NMP (2.0M N,N-Diisopropylethylamine, 98+% N,N-Diisopropylethylamine, 99.5+% N,N-Diisopropylethylamine/1-Methyl-2-pyrrolidinone, 2 bottles kit for 2.0M solution, for peptide synt. DIISOPROPYLETHYLAMINE (DIEA) DIEA N,N’-Diisopropyl ethylamine N,N-DIISOPROPYLETHYLAMINE (HUENIGS BASE) Hμnigs base, N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine N,N-Diisopropylethanamine N,N-Diisopropylethylamine/1-Methyl-2-pyrrolidinone,2 bottles kit for 2.0M solution, for pe N,N-Diisopropylethylamine ,99.5% [Moisture content≤300PPM] N-Ethyldiisopropylamine solution,N,N-Diisopropylethylamine, DIPEA, Hünig’s base N-Ethyldiisopropylamine,N,N-Diisopropylethylamine, Hünigs base DIISOPROPYLETHYLAMINE/WATER, PROTEINSEQU ENCING GRA N,N-Diisopropylethyl N-ethyl-N-propan-2-yl-propan-2-amine N,N-DIISOPROPYLETHYLAMINE N-ETHYLDISSOPROPLYAMINE (CH3)2CHN(C2H5)CH(CH3)2 N,N-Diisopropylethylamine, Ethyldiisopropylamine, Hμnigs base N,N-Diisopropylethylamine, Hμnigs base N,N-DiisopropylethylaMine, 98+% 100GR N,N-DiisopropylethylaMine, 98+% 25GR N,N-DiisopropylethylaMine, 98+% 500GR N,N-DiisopropylethylaMine, 99.5+% 100ML N,N-DiisopropylethylaMine, 99.5+% 50ML N-DiisopropylethylaMine (DIPEA) EthyldiisopropylaMine(DIEA EDIA) N-Ethyldiisopropylamine DIPEA Hunig's Base N-Ethyldiisopropylamine BASF quality, >=98.0% MEDIABAG B WITH 375 G SKIMMED MILK N,N-diisopropyethyl amine N,N'-Diisopropylethylamine≥ 99.7% (GC) N-Ethyldiisopropylamin N-Ethyl-N-(1-methylethyl)-2-methylethanamine n-ethyl-n-(1-methylethyl)-2-propanamin N-Ethyl-N-isopropyl-2-propanamine Triethylamine, 1,1'-dimethyl- Triethylamine,1,1’-dimethyl- 1,1’-Dimethyltriethylamine 2-Propanamine, N-ethyl-N-(1-methylethyl)- 2-Propanamine,N-ethyl-N-(1-methylethyl)- Bis(1-methylethyl)ethylamine Hünig’sBase N,N-DIISOPROPYLETHYLAMINE (HONIG''S BASE) DI-DEHYDROCOELENTERAZINE