ChemicalBook >> CAS DataBase List >>Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo-

Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo-

Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- structure

CAS No.: 2377881-92-8

Chemical Name:: Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo-

Synonyms: MSA-2 dimer;MSA 2 dimer,MSA2 dimer;Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo-

CBNumber:: CB48769820

Molecular Formula:: C29H28O8S2

Molecular Weight:: 568.66

MDL Number:

MOL File:: 2377881-92-8.mol

Last updated:2023-02-23 14:24:08

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Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Properties

Boiling point	817.6±65.0 °C(Predicted)
Density	1.376±0.06 g/cm3(Predicted)
pka	4.10±0.17(Predicted)

Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Chemical Properties,Uses,Production

Biological Activity

MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide[1]. MSA-2 dimer (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival[1]. MSA-2 dimer (40 mg/kg; s.c.; 25 days) induces complete tumor regression[1].MSA-2 dimer (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) level in tumors[1].MSA-2 dimer (60 mg/kg; s.c.; 4 hours) concentrations is observed in tumors than in plasma or other nontumor tissues [1].MSA-2 dimer (THP-1 cells) induces phosphorylation of both TBK1 and IR. MSA-2 dimer (10 μM and 33 μM; macrophages) induces IFN-β[1].MSA-2 dimer also exhibits dose-dependent antitumor activity when administered by IT, SC, or PO routes[1].

References

[1]. Pan BS, et al. An orally available non-nucleotide STING agonist with antitumor activity. Science. 2020;369(6506):eaba6098.

Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4164	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5019	58

Supplier	Advantage
Aladdin Scientific	58
TargetMol Chemicals Inc.	58
Nantong QuanYi Biotechnology Co., Ltd	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58

MSA-2 dimer Benzo[b]thiophene-2-butanoic acid, 5,5'-(1,3-propanediyl)bis[6-methoxy-γ-oxo- MSA 2 dimer,MSA2 dimer 2377881-92-8 C29H28O8S2