D-METHAMPHETAMINE
- CAS No.
- 537-46-2
- Chemical Name:
- D-METHAMPHETAMINE
- Synonyms
- Metamfetamine;LEVMETAMFETAMINE;Methylamphetamine;crystal;Metamphetamine;N-Methylamphetamine;methedrine;n-methyl-beta-phenylisopropylamin;(S)-N-methyl-1-phenylpropan-2-amine;(2S)-N-methyl-1-phenylpropan-2-amine
- CBNumber:
- CB5101667
- Molecular Formula:
- C10H15N
Lewis structure
- Molecular Weight:
- 149.24
- MDL Number:
- MFCD00079140
- MOL File:
- 537-46-2.mol
| Melting point | 143°C (estimate) |
|---|---|
| Boiling point | 230.33°C (estimate) |
| Density | 0.9285 (estimate) |
| refractive index | 1.5105 (estimate) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| pka | 10.38±0.10(Predicted) |
| EWG's Food Scores | 1 |
| FDA UNII | 44RAL3456C |
| ATC code | N06BA03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P260-P280-P301+P310-P311 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 16-36/37-45 |
| RIDADR | 1851 |
| WGK Germany | 1 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | A widely abused drug; a sympathomimetic and central stimulant that has been used clinically as an anorectic agent. The use of methamphetamine and related drugs in treating obesity is, however, now generally discredited. It may cause elevation of blood pressure, palpitation, and tachycardia, as well as various CNS effects, including psychotic effects at higher doses. Chronic use of methamphetamine and related compounds, especially at high doses as often occurs with drug abuse, can cause a condition often indistinguishable from schizophrenia. Abrupt withdrawal may cause fatigue, depression, and sleep changes. Methamphetamine is an indirect-acting adrenergic and dopamine agonist that acts principally to release endogenous catecholamines, thereby increasing their synaptic availability. Many of its actions can be blocked by adrenergic and dopamine antagonists. The i.p. LD50 in mice is 70 mg/kg. |
D-METHAMPHETAMINE Chemical Properties,Uses,Production
Originator
Desoxyn ,Abbott Laboratories
Uses
Nasal decongestant.
Definition
ChEBI: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Manufacturing Process
2 Methods of prepearing of methamphetamine:
1. (-)-Ephedrin was reduced by hydrogenesation with hydrogen in the presence of Pt-C catalyst to give the (+)-N-α-dimethylphenethylamine (methamphetamine), melting point 172°-174°C.
2. Methamphetamine was obtained by the methylation of
phenylisopropylamine.
To give methamphetamine hydrochloride the base methamphetamine was
treated by eqimolar quantity of hydrochloric acid.
brand name
Amone;Desoxyn;Dexophrine;Dexoval;Doxyfed;Doxyn Drinalfa;Efroxine;Euphrodinal;Gardstat;Gerobit;Geronyl;Lemobese;Madrine;Mediatric;Meloda;Metamsustac;Methampex;Methedrinal;Neodrine-triple;Obedrin-la;Obelones;Obe-slim;Pervitin;Phedrisox;Phelantin;Philopon;Soxympamine;Syndrox;Tonedron;Uno.
Therapeutic Function
Sympathomimetic, Central stimulant
World Health Organization (WHO)
Metamfetamine, an amfetamine derivative, is controlled under Schedule II of the 1971 Convention on Psychotropic Substances. See WHO comment for amfetamine. (Reference: (UNCPS2) United Nations Convention on Psychotropic Substances (II), , , 1971)
D-METHAMPHETAMINE Preparation Products And Raw materials
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