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INDOMETHACIN ESTER, N-HEPTYL-

INDOMETHACIN ESTER, N-HEPTYL- structure

CAS No.: 282728-47-6

Chemical Name:: INDOMETHACIN ESTER, N-HEPTYL-

Synonyms: INDOMETHACIN HEPTYL ESTER;PYBCHCVNKGZCOH-UHFFFAOYSA-N;INDOMETHACIN ESTER, N-HEPTYL-;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester;1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, 1-HEPTYL ESTER;1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER;1-(P-CHLOROBENZOYL)-5-METHOXY-3-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER

CBNumber:: CB5105498

Molecular Formula:: C26H30ClNO4

Molecular Weight:: 455.97

MDL Number:: MFCD03412025

MOL File:: Mol file

Last updated:2023-09-04 15:51:00

Request For Quotation

INDOMETHACIN ESTER, N-HEPTYL- Properties

Flash point	-16 °C
storage temp.	−20°C
solubility	≤17mg/ml in ethanol;17mg/ml in DMSO;17mg/ml in dimethyl formamide
form	methyl acetate solution

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H319-H336

Precautionary statements

P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501

Hazard Codes

F,Xi

Risk Statements

11-36-66-67

Safety Statements

16-26-29-33-36

RIDADR

UN 1231 3/PG 2

WGK Germany

RTECS

AI9100000

NFPA 704

	3
2		0

INDOMETHACIN ESTER, N-HEPTYL- price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	70271	Indomethacin heptyl ester ≥98%	282728-47-6	1mg	$25	2024-03-01	Buy
Cayman Chemical	70271	Indomethacin heptyl ester ≥98%	282728-47-6	5mg	$107	2024-03-01	Buy
Cayman Chemical	70271	Indomethacin heptyl ester ≥98%	282728-47-6	10mg	$186	2024-03-01	Buy
Cayman Chemical	70271	Indomethacin heptyl ester ≥98%	282728-47-6	50mg	$807	2024-03-01	Buy
ApexBio Technology	C4718	Indomethacinheptylester	282728-47-6	10mg(solution)	$210	2021-12-16	Buy

Product number	Packaging	Price	Buy
70271	1mg	$25	Buy
70271	5mg	$107	Buy
70271	10mg	$186	Buy
70271	50mg	$807	Buy
C4718	10mg(solution)	$210	Buy

INDOMETHACIN ESTER, N-HEPTYL- Chemical Properties,Uses,Production

Description

Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC₅₀ for indomethacin heptyl ester for the inhibition of human recombinant COX-2 is 0.04 μM, making it more than 1,700 times more potent as an inhibitor of COX-2 than COX-1. While indomethacin itself has an IC₅₀ of 0.05 μM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC₅₀ of 0.67 μM.

Definition

ChEBI: Indomethacin heptyl ester is a N-acylindole.

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

INDOMETHACIN ESTER, N-HEPTYL- Preparation Products And Raw materials

Raw materials

Preparation Products

INDOMETHACIN ESTER, N-HEPTYL- Suppliers

Global( 28)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	sales@szzxbio.com	China	2992	58
Shanghai YuZn Pharm. Technology Co.,Ltd.	15921286451; 15921286451	2010681527@qq.com	China	5067	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
ApexBio Technology	--	sales@apexbt.com	United States	6254	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12007	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Guangzhou Isun Pharmaceutical Co., Ltd	55
MedBioPharmaceutical Technology Inc	58
TargetMol Chemicals Inc.	58
Suzhou Zhixin Biotechnology Co., Ltd.	58
Shanghai YuZn Pharm. Technology Co.,Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
ApexBio Technology	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

INDOMETHACIN ESTER, N-HEPTYL- Spectrum

INDOMETHACIN ESTER, N-HEPTYL-(282728-47-6)¹HNMR

INDOMETHACIN ESTER, N-HEPTYL- INDOMETHACIN HEPTYL ESTER 1-(P-CHLOROBENZOYL)-5-METHOXY-3-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER 1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, 1-HEPTYL ESTER PYBCHCVNKGZCOH-UHFFFAOYSA-N 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester 282728-47-6 Enzymes, Inhibitors, and Substrates Cyclooxygenase (COX) Enzymes Cyclooxygenase Inhibitors Cell Signaling Enzymes Application Index Biochemicals and Reagents BioChemical Cyclooxygenase InhibitorsCancer Research A to Arachidonic Acid Cascade Chemopreventive Agents Cyclooxygenase (COX) Enzymes CyclooxygenaseCell Signaling Enzymes CyclooxygenaseEnzyme Inhibitors by Enzyme Enzyme Inhibitors