ChemicalBook >> CAS DataBase List >>CUCURBITACIN B
CUCURBITACIN B
- CAS No.
- 6199-67-3
- Chemical Name:
- CUCURBITACIN B
- Synonyms
- Cuc B;AMARINE;HSDB 3476;DATISCACIN;NSC-144154;heMsecin A;Cucurbitacin;cucuritacin B;CUCURBITACIN B;cucurbitacineb
- CBNumber:
- CB5113260
- Molecular Formula:
- C32H46O8
- Molecular Weight:
- 558.7
- MDL Number:
- MFCD07778083
- MOL File:
- 6199-67-3.mol
- MSDS File:
- SDS
Last updated:2024-04-08 16:27:35
| Melting point | 184-186° |
|---|---|
| alpha | D25 +88° (c = 1.55 in ethanol) |
| Boiling point | 546.74°C (rough estimate) |
| Density | 1.0953 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| pka | 12.60±0.29(Predicted) |
| color | white to beige |
| λmax | 290nm(EtOH)(lit.) |
| Merck | 14,2614 |
| Stability | Hygroscopic |
| InChIKey | IXQKXEUSCPEQRD-ALLWXVAWSA-N |
| FDA UNII | 0115W5MABF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45-24/25 | |||||||||
| RIDADR | UN 2811 6.1 / PGI | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC6190000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29153900 | |||||||||
| Toxicity | LD10 orally in mice: 5 mg/kg (LeMen) | |||||||||
| NFPA 704 |
|
CUCURBITACIN B price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C8499 | Cucurbitacin B hydrate ≥97% (HPLC) | 6199-67-3 | 5mg | $256 | 2024-03-01 | Buy |
| Sigma-Aldrich | C8499 | Cucurbitacin B hydrate ≥97% (HPLC) | 6199-67-3 | 25mg | $1020 | 2024-03-01 | Buy |
| TCI Chemical | C3442 | Cucurbitacin B >98.0%(HPLC) | 6199-67-3 | 5mg | $158 | 2024-03-01 | Buy |
| TCI Chemical | C3442 | Cucurbitacin B >98.0%(HPLC) | 6199-67-3 | 25mg | $478 | 2024-03-01 | Buy |
| Cayman Chemical | 14820 | Cucurbitacin B ≥98% | 6199-67-3 | 1mg | $37 | 2024-03-01 | Buy |
CUCURBITACIN B Chemical Properties,Uses,Production
Description
Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.
Chemical Properties
White solid
Uses
Cucurbitacin B hydrate has been used:
- as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
- as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
- to determine its effect on the cell viability of pancreatic cancer cell lines.
Definition
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.
Biochem/physiol Actions
Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.
CUCURBITACIN B Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 258)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7786 | 58 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
View Lastest Price from CUCURBITACIN B manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-08 | CUCURBITACIN B
6199-67-3
|
US $8.00-0.80 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-11-13 | CUCURBITACIN B
6199-67-3
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-27 | Cucurbitacin B
6199-67-3
|
US $20.00-1.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- CUCURBITACIN B
6199-67-3
- US $8.00-0.80 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- CUCURBITACIN B
6199-67-3
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Cucurbitacin B
6199-67-3
- US $20.00-1.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
6199-67-3(CUCURBITACIN B)Related Search:
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24-epi-Cucurbitacin G,Cucurbitacin G,Cucurbitacin H
Cucurbitacin A
Cucurbitacin F
Cucurbitacin L
dihydrocucurbitacin F
Calebassine
Cucurbitacin Ia,Cucurbitacin F-25-acetate
CUCURBITACIN B
1of4
(2beta,9beta,10alpha,16alpha,23e)-thyl
19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25
19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet
19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me
25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr
Cucurbitacin B hydrate
cucurbitacineb
AMARINE
1,2-DIHYDRO-ALPHA-ELATERIN
CUCURBITACIN B
DATISCACIN
Dihydrocucurbitacin F-25-acetate
Cucurbitacin
HSDB 3476
CUCURBITACIN B(RG)
(23E)-25-(Acetyloxy)-2β,16α,20-trihydroxycucurbita-5,23-diene-3,11,22-trione
(9β,10α,23E)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione
NSC-144154
Cucurbitacin B ,97%
CUCURBITACIN B(P)
heMsecin A
Cucurbitacin B, froM CucuMis Melo
(2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione
Cucurbitacin B, 98%, from Cucumis melo L.
Cucurbitacin B, >99%
Cucurbitacin B, 98%, from Cucumis melo
BCucurbitacin B
Cuc B
19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)-
CUCURBITACIN B USP/EP/BP
CAS?6199-67-3?Combretastatin A4 (Z) -Combretastatin A4 CAS 117048-59-6
cucuritacin B
(+)-Cucurbitacin B
(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate
6199-67-3
C32H46O8
Tri-Terpenoids
chemical reagent
pharmaceutical intermediate
phytochemical
reference standards from Chinese medicinal herbs (TCM).
standardized herbal extract