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Dichloroacetic acid methyl ester

CAS No.
116-54-1
Chemical Name:
Dichloroacetic acid methyl ester
Synonyms
METHYL DICHLOROACETATE;NSC 2882;TwoMethyl chloroacetate;methyldichloroethanoate;methyl2,2-dichloroacetate;Dichloroacetic acid methyl;Methyl Dichloroacetate >Methyl dichloroacetate,purum;METHYL DICHLOROACETATE, 99+%;dichloro-aceticacimethylester
CBNumber:
CB5115244
Molecular Formula:
C3H4Cl2O2
Molecular Weight:
142.97
MDL Number:
MFCD00000843
MOL File:
116-54-1.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

Dichloroacetic acid methyl ester Properties

Melting point -52 °C (lit.)
Boiling point 143 °C (lit.)
Density 1.381 g/mL at 25 °C (lit.)
refractive index n20/D 1.442(lit.)
Flash point 176 °F
storage temp. room temp
solubility 4g/l
form Liquid
color Clear colorless
PH 3.8 (4g/l, H2O, 20℃)
Water Solubility Slightly soluble
BRN 1747542
CAS DataBase Reference 116-54-1(CAS DataBase Reference)
FDA UNII HG7W497BZU
NIST Chemistry Reference Acetic acid, dichloro-, methyl ester(116-54-1)
EPA Substance Registry System Acetic acid, 2,2-dichloro-, methyl ester (116-54-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H332-H335
Precautionary statements  P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn,Xi,F
Risk Statements  20-36/37/38-40-38-11
Safety Statements  26-36-37/39-16-24-9
RIDADR  UN 2299 6.1/PG 3
WGK Germany  3
RTECS  AG6625000
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29154000
NFPA 704
1
2 0

Dichloroacetic acid methyl ester price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 35840 Methyl dichloroacetate ≥99% 116-54-1 500ml $97.3 2024-03-01 Buy
TCI Chemical D0309 Methyl Dichloroacetate >99.0%(GC) 116-54-1 25g $17 2024-03-01 Buy
TCI Chemical D0309 Methyl Dichloroacetate >99.0%(GC) 116-54-1 500g $57 2024-03-01 Buy
Alfa Aesar B24399 Methyl dichloroacetate, 99% 116-54-1 100g $33.65 2024-03-01 Buy
Alfa Aesar B24399 Methyl dichloroacetate, 99% 116-54-1 500g $65.65 2024-03-01 Buy
Product number Packaging Price Buy
35840 500ml $97.3 Buy
D0309 25g $17 Buy
D0309 500g $57 Buy
B24399 100g $33.65 Buy
B24399 500g $65.65 Buy

Dichloroacetic acid methyl ester Chemical Properties,Uses,Production

Chemical Properties

clear colorless liquid

Uses

Organic intermediate.

Uses

Dichloroacetic Acid Methyl Ester is used in the preparation of telechelics and block copolymers through living radical polymerization.

Uses

Methyl dichloroacetate may be used:

  • in the diastereoselctive synthesis of bicyclic chlorocyclopropane
  • as difunctional initiator during atom transfer radical polymerization of methyl or n-butyl acrylate
  • as reagent during CrCl2-induced olefination of aldehydes

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 5307, 1968 DOI: 10.1021/ja01021a065
The Journal of Organic Chemistry, 28, p. 1133, 1963

General Description

A colorless liquid with an ethereal odor. Combustible. Flash point 176°F. Corrosive to metals and tissue. Used to make other chemicals.

Air & Water Reactions

Decomposed by water to dichloroacetic acid, a corrosive material with evolution of heat [USCG, 1999].

Reactivity Profile

Dichloroacetic acid methyl ester produces toxic fumes of phosgene and HCl when heated [USCG, 1999].

Hazard

Strong irritant to tissue. Forms corrosiveproducts on hydrolysis, keep dry.

Health Hazard

Extremely destructive to the eyes, nose, throat, and upper respiratory tract. May be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Fire Hazard

Special Hazards of Combustion Products: Produces toxic fumes of phosgene and HCl.

Safety Profile

Poisonous irritant to the skin, eyes, and mucous membranes. Hydrolyzes upon contact with moisture to form a product corrosive to tissue. See also DICHLOROACETIC ACID and ESTERS. Dangerous; when heated to decomposition it emits hghly toxic fumes of phosgene and Cl-.

79-36-7
116-54-1
Synthesis of Dichloroacetic acid methyl ester from Dichloroacetyl chloride

Dichloroacetic acid methyl ester Preparation Products And Raw materials

Global( 227)Suppliers
Supplier Tel Email Country ProdList Advantage
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SIMAGCHEM CORP
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View Lastest Price from Dichloroacetic acid methyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dichloroacetic acid methyl ester pictures 2021-07-02 Dichloroacetic acid methyl ester
116-54-1
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Dichloroacetic acid methyl ester pictures 2020-01-08 Dichloroacetic acid methyl ester
116-54-1
US $2.00 / KG 1KG 99 100kg Career Henan Chemical Co
Methyl dichloroacetate   pictures 2020-01-03 Methyl dichloroacetate
116-54-1
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
Methyl dichloroacetate solution 1,1-Dichloro-2-methoxy-2-oxoethane Dichloroacetic acid methyl Methyl dichloroacetate, synthesis grade Methyl dichloroacetate,purum TwoMethyl chloroacetate dichloro-aceticacimethylester ethanoicacid,dichloro-,methylester methyl2,2-dichloroacetate methyldichloroethanoate DIMETHOXYACETIC ACID METHYL ESTER DICHLOROACETIC ACID METHYL ESTER NSC 2882 METHYL DICHLOROACETATE PESTANAL METHYL DICHLOROACETATE, 99+% METHYL DICHLOROACETATE extrapure METHYL DICHLOROACETATE, 1000MG, NEAT Aceticacid,dichloro-,methylester Methyl Dichloroacetate > Acetic acid, 2,2-dichloro-, methyl ester Dichloroacetic acid methyl ester ISO 9001:2015 REACH METHYL DICHLOROACETATE 116-54-1 16-54-1 Cl2CHCO2CH3 Cl2CHCOOCH3 Cl2CHOOCH3 Organic Building Blocks Esters Building Blocks Carbonyl Compounds C2 to C5 Alpha sort Pharmaceutical Intermediates 500 Series Drinking Water Methods EPA Method 552 H-MAlphabetic M META - METH Pesticides&Metabolites Pyrans C2 to C5 Carbonyl Compounds Esters