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Piperidine hydrochloride

CAS No.
6091-44-7
Chemical Name:
Piperidine hydrochloride
Synonyms
PIPERIDINE HCL;Piperidiniumchlorid;PIPERIDINIUM CHLORIDE;Piperidin-hydrochlorid;6091-44-7, MFCD00012770;PIPERIDINE HYDROCHLORIDE;Piperidin-1-ium chloride;Eperisone Impurity 5 HCl;PIPERIDINIUM HYDROCHLORIDE;Piperidinehydrochloride,99%
CBNumber:
CB5115860
Molecular Formula:
C5H11N.ClH
Molecular Weight:
121.61
MDL Number:
MFCD00012770
MOL File:
6091-44-7.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

Piperidine hydrochloride Properties

Melting point 245-248 °C(lit.)
Boiling point 347.05℃
Density 1,12 g/cm3
vapor density 2.94 (vs air)
vapor pressure 63.6 mm Hg ( 37.8 °C)
Flash point >230 °F
storage temp. Store below +30°C.
solubility >1500g/l
form Solid:crystalline
PH 6-8 (111g/l, H2O, 20℃)
Water Solubility soluble
Sensitive Hygroscopic
BRN 3611699
InChIKey VEIWYFRREFUNRC-UHFFFAOYSA-N
LogP -1.92
CAS DataBase Reference 6091-44-7(CAS DataBase Reference)
FDA UNII 5MY66P6N3M
EPA Substance Registry System Piperidine hydrochloride (6091-44-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25-37-36/37/38-23/24/25
Safety Statements  36/37/39-45-28A-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  1
RTECS  TN0400000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29333200
NFPA 704
1
3 1

Piperidine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

WHITE FINE CRYSTALLINE POWDER

Uses

Reagent for synthesis of:

  • Quinoline selenium compounds
  • Peripheral seratonin 5-HT3 receptor ligands

Reactant for synthesis of phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors

Reactant for:
  • Mannich reactions
  • Asymmetric hydrogenation of quinolines
  • Chemoselective reductive amination of carbonyl compounds

Uses

Piperidine hydrochloride is used an intermediate in the manufacture of active pharmaceutical ingredients like anti Parkinsonan agent Biperiden; anti depressant agent Clocapramine hydrochloride and muscle relaxant tolperisone.

Purification Methods

Crystallise the salt from EtOH/diethyl ether in the presence of a small amount of HCl. [Beilstein 20 H 6, 20 II 10, 20 III/IV 295, 20/2 V 13.]

544-13-8
6091-44-7
Synthesis of Piperidine hydrochloride from Glutaronitrile

Piperidine hydrochloride Preparation Products And Raw materials

hexahydropyridinehydrochloride PIPERIDINE HYDROCHLORIDE PIPERIDINIUM CHLORIDE PIPERIDINIUM HYDROCHLORIDE PIPERIDINE HYDROCHLORIDE, CRYSTALLIZED Piperidinehydrochloride,99% Piperidiniumchlorid PIPERIDINE HCL PIPERIDINE HYDROCHLORIDE Piperidin-1-ium chloride Piperidinium chloride for synthesis Piperidine Hydrochloride (Low water content) Piperidine hydrochloride cas: 6091-44-7 6091-44-7, MFCD00012770 Piperidin-hydrochlorid PIPERIDINE HCL Piperidine, hydrochloride (7CI, 8CI, 9CI) Trihexyphenidyl impurity 16 (piperidine hydrochloride) Eperisone Impurity 5 HCl 6091-44-7 C5H11NHCl C5H10ClNClH C5H12N Piperidines Heterocyclic Building Blocks Building Blocks Piperidine Building Blocks Heterocyclic Building Blocks Piperidines