PHORBOL 12,13-DIBUTYRATE
- CAS No.
- 37558-16-0
- Chemical Name:
- PHORBOL 12,13-DIBUTYRATE
- Synonyms
- PDBU;C03634;Phorbol 12;13-dibutyrate;PHORBOL 12,13-DIBUTYRATE;Phorbol 12,13-dibutanoate;Phorbol 12,13-Dibutyrate >99%;PHORBOL 12,13-DIBUTYRATE, 4BETA;Phorbol 12,13dibutyrate,Phorbol 12,13 dibutyrate;Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem
- CBNumber:
- CB5117703
- Molecular Formula:
- C28H40O8
- Molecular Weight:
- 504.61
- MDL Number:
- MFCD00036783
- MOL File:
- 37558-16-0.mol
- MSDS File:
- SDS
| Boiling point | 513.95°C (rough estimate) |
|---|---|
| Density | 1.1270 (rough estimate) |
| refractive index | 1.4480 (estimate) |
| storage temp. | -20°C |
| solubility | H2O: 30 μM |
| pka | 11.15±0.70(Predicted) |
| form | powder |
| color | clear, light yellow, film |
| BRN | 6551234 |
| CAS DataBase Reference | 37558-16-0(CAS DataBase Reference) |
| FDA UNII | 67MX82CL58 |
| EPA Substance Registry System | Phorbol 12,13-dibutyrate (37558-16-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H314-H317-H334-H351 | |||||||||
| Precautionary statements | P202-P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 2928 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EK7767000 | |||||||||
| F | 8-10 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2915601990 | |||||||||
| NFPA 704 |
|
PHORBOL 12,13-DIBUTYRATE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 524390 | Phorbol-12,13-dibutyrate | 37558-16-0 | 1mg | $99.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 524390 | Phorbol-12,13-dibutyrate | 37558-16-0 | 5mg | $289 | 2024-03-01 | Buy |
| Cayman Chemical | 27785 | Phorbol 12,13-dibutyrate | 37558-16-0 | 1mg | $79 | 2024-03-01 | Buy |
| Cayman Chemical | 27785 | Phorbol 12,13-dibutyrate | 37558-16-0 | 5mg | $254 | 2024-03-01 | Buy |
| Sigma-Aldrich | P1269 | Phorbol 12,13-dibutyrate ≥98% (TLC), powder | 37558-16-0 | 1mg | $107 | 2024-03-01 | Buy |
PHORBOL 12,13-DIBUTYRATE Chemical Properties,Uses,Production
Uses
Phorbol 12,13-dibutyrate has been used as a protein kinase C (PKC) activator to study its effects on human organic anion transporter 4 (hOAT4) activity. It has also been used as a PKC activator to analyze its effects on galectin-3 expression and matrix production in HL-1 cells.
Definition
ChEBI: Phorbol 12,13-dibutanoate is a phorbol ester, a butyrate ester and a tertiary alpha-hydroxy ketone.
General Description
White solid.
Reactivity Profile
PHORBOL 12,13-DIBUTYRATE may be sensitive to prolonged exposure to air, light and ambient temperatures. PHORBOL 12,13-DIBUTYRATE may also be subject to autooxidation.
Fire Hazard
The flash point of PHORBOL 12,13-DIBUTYRATE has not been determined, but PHORBOL 12,13-DIBUTYRATE is probably combustible.
Biological Activity
phorbol 12,13-dibutyrate, a phorbol ester, is an activator of pkc, including the conventional calcium-dependent subtypes (α and γ), the nonconventional calcium-independent isoforms (δ, ε, η), as well as the atypical calcium-independent and dag or phorbol ester-unresponsive subtype (ζ). pkc plays an important role in the regulation of a variety of cellular processes such as exocytosis, gene expression, cell proliferation and differentiation, as well as tumor promotion, thereby representing the major target for tumor-promoting phorbol esters and chemically unrelated tumor promoters. phorbol esters are able to replace the endogenous activator dag in the stimulation of pkc, and participate in the multistage process of tumor formation and progression.1. geiges d, meyer t, marte b, et al. activation of protein kinase c subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. biochemical pharmacology, 1997, 53(6): 865-875.2. middleton jp, khan wa, collinsworth g, et al. heterogeneity of protein kinase c-mediated rapid regulation of na/k-atpase in kidney epithelial cells. journal of biological chemistry, 1993, 268(21): 15958-15964.3. scribner jd, boutwell rk. inflammation and tumor promotion: selective protein induction in mouse skin by tumor promoters. european journal of cancer, 1972, 8(6): 617-621.
Biochem/physiol Actions
Phorbol 12,13-dibutyrate (PDBu) is a potent activator of protein kinase C (PKC). It is more hydrophilic than phorbol 12-myristate 13-acetate (PMA), which facilitates washing PDBu out of cells in tissue culture. PDBu activates endothelial nitric oxide synthase expression in primary human umbilical vein endothelial cells, which in turn correlates with PKC α and ε expression.
storage
Store at -20°C
PHORBOL 12,13-DIBUTYRATE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
View Lastest Price from PHORBOL 12,13-DIBUTYRATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-01-06 | PHORBOL 12,13-DIBUTYRATE
37558-16-0
|
US $0.37 / KG | 1KG | 99% | 10kg/100kg | Career Henan Chemica Co |
-
- PHORBOL 12,13-DIBUTYRATE
37558-16-0
- US $0.37 / KG
- 99%
- Career Henan Chemica Co