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4-Nitroacetophenone

4-Nitroacetophenone structure

CAS No.: 100-19-6

Chemical Name:: 4-Nitroacetophenone

Synonyms: 1-(4-NITROPHENYL)ETHAN-1-ONE;Nitroacetophenone;1-(4-nitrophenyl)ethanone;PNAP;P-NITROACETOPHENONE;NSC 41590;Bromo-2’AURORA KA-7140;AKOS BBS-00003219;p-Nitroacetophenon

CBNumber:: CB5118997

Molecular Formula:: C8H7NO3

Molecular Weight:: 165.15

MDL Number:: MFCD00007355

MOL File:: 100-19-6.mol

MSDS File:: SDS

Last updated:2024-03-21 18:02:16

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4-Nitroacetophenone Properties

Melting point	75-78 °C(lit.)
Boiling point	202 °C(lit.)
Density	1.3450 (rough estimate)
refractive index	1.5468 (estimate)
Flash point	201-202°C
storage temp.	Sealed in dry,Room Temperature
form	Crystalline Powder
color	Yellow
Water Solubility	Insoluble in water.
BRN	607777
InChIKey	YQYGPGKTNQNXMH-UHFFFAOYSA-N
CAS DataBase Reference	100-19-6(CAS DataBase Reference)
FDA UNII	4FM2J8HQ27
NIST Chemistry Reference	Acetophenone, 4'-nitro-(100-19-6)
EPA Substance Registry System	4-Nitroacetophenone (100-19-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS06

Signal word

Warning

Hazard statements

H302-H301

Precautionary statements

P301+P310a-P321-P405-P501a-P264-P270-P301+P312+P330-P501

Hazard Codes

Risk Statements

36-22

Safety Statements

22-24/25

WGK Germany

RTECS

AM9627000

Hazard Note

Harmful

HS Code

29147090

NFPA 704

	0
1		0

4-Nitroacetophenone price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	N9608	4′-Nitroacetophenone 98%	100-19-6	5g	$48.2	2024-03-01	Buy
Sigma-Aldrich	N9608	4′-Nitroacetophenone 98%	100-19-6	100g	$71.3	2024-03-01	Buy
TCI Chemical	N0111	4'-Nitroacetophenone >98.0%(GC)	100-19-6	25g	$32	2024-03-01	Buy
TCI Chemical	N0111	4'-Nitroacetophenone >98.0%(GC)	100-19-6	100g	$71	2024-03-01	Buy
Alfa Aesar	A13877	4'-Nitroacetophenone, 98%	100-19-6	50g	$29.8	2024-03-01	Buy

Product number	Packaging	Price	Buy
N9608	5g	$48.2	Buy
N9608	100g	$71.3	Buy
N0111	25g	$32	Buy
N0111	100g	$71	Buy
A13877	50g	$29.8	Buy

4-Nitroacetophenone Chemical Properties,Uses,Production

Chemical Properties

The pure product is pale yellow crystal or needle crystal. Soluble in hot ethanol, ether and benzene, insoluble in water. 4-Nitroacetophenone is the raw material for the manufacture of synthomycin and chloramphenicol.

Uses

4''-Nitroacetophenone is used as a reagent in the synthesis of 4-Nitroacetophenone thiosemicarbazone derivatives and their copper(II) complexes which have potential anti-trypanosomal activity in vitro. Also used as a reagent in the synthesis of (R)-(4-Nitrophenyl)oxirane (N504430) and (S)-(4-Nitrophenyl)oxirane (N504435).

Definition

ChEBI: 4-nitroacetophenone is a member of the class of acetophenones that is acetophenone substituted at the para-position by a nitro group. It is a C-nitro compound and a member of acetophenones.

Preparation

In the presence of catalyst cobalt stearate, p-nitroethylbenzene is oxidized to synthesize 4-nitroacetophenone with air at 140-150°C and 0.2MPa pressure. The reaction product is washed with water, neutralized, centrifugally dehydrated, and dried to obtain a finished product.

Application

One of several alternative routes to synthetic chloroamphenicol uses 4-nitroacetophenone as starting material with a first-stage bromination to α-bromo-4-nitroacetophenone followed by buildup of the side chain. α-bromo-4-nitroacetophenone is the key precursor in the synthesis of the bronchodilator clenbuterol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 4634, 1983 DOI: 10.1021/jo00172a038
Synthetic Communications, 26, p. 291, 1996 DOI: 10.1080/00397919608003617

General Description

P-nitroacetophenone appears as yellow prisms or bright yellow powder. (NTP, 1992)

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A nitrated ketone. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.

Fire Hazard

Flash point data for 4-Nitroacetophenone are not available. 4-Nitroacetophenone is probably combustible.

Purification Methods

Crystallise the ketone from EtOH or aqueous EtOH. [Beilstein 7 IV 657.]

4-Nitroacetophenone Preparation Products And Raw materials

Raw materials

4-Nitrobenzoyl chloride Ethylbenzene Cobalt stearate 4-Nitroethylbenzene p-Nitroethylbenzene 2-Ethylnitrobenzene

Nitric acid Sodium hydroxide Sulfuric acid

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Preparation Products

3-(4-NITRO-PHENYL)-ISOXAZOL-5-YLAMINE A-BROMO-4-NITROACETOPHENONE HEXAMINE DL-THREO-2-ACETAMIDO-L-(4-NITROPHENYL)-L,3-PROPANEDIOL 5-(4-NITROPHENYL)-2H-PYRAZOL-3-YLAMINE CLENBUTEROL

4-(1,2,3-THIADIAZOL-4-YL)ANILINE 4-(4-NITROPHENYL)-1,2,3-THIADIAZOLE Chloramphenicol DIETHOXYMETHANE 2-Ethylnitrobenzene

4-AMINO-ALPHA-TERT-BUTYLAMINE-3,5-DICHLOROACETOPHENONE 4'-AMINOBUTYROPHENONE 4-Aminoacetophenone N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxoethyl]acetamide FGH-10019

2-METHYL-2-(4-NITROPHENYL)-2-PROPANOL

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4-Nitroacetophenone Suppliers

Global( 365)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-19164747840 +86-13119157289	13119157289@163.com	China	2971	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2967	58
Accela ChemBio Inc.	(+1)-858-699-3322	info@accelachem.com	United States	19965	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Jinan Finer Chemical Co., Ltd	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58

View Lastest Price from 4-Nitroacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-25	4-Nitroacetophenone 100-19-6	US $0.00 / kg	50kg	HPLC≥98%	10000kg	Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
2024-04-12	4-Nitroacetophenone 100-19-6	US $0.00 / kg	1kg	99%	2000ton	Shaanxi Haibo Biotechnology Co., Ltd
2023-09-05	4-Nitroacetophenone 100-19-6	US $40.00 / kg	1kg	0.99	10 tons	Hebei Yanxi Chemical Co., Ltd.

4-Nitroacetophenone
100-19-6
US $0.00 / kg
HPLC≥98%
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

4-Nitroacetophenone
100-19-6
US $0.00 / kg
99%
Shaanxi Haibo Biotechnology Co., Ltd

4-Nitroacetophenone
100-19-6
US $40.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

4-Nitroacetophenone Spectrum

4-Nitroacetophenone(100-19-6)MS 4-Nitroacetophenone(100-19-6)¹HNMR 4-Nitroacetophenone(100-19-6)¹³CNMR 4-Nitroacetophenone(100-19-6)IR1 4-Nitroacetophenone(100-19-6)IR2 4-Nitroacetophenone(100-19-6)IR3 4-Nitroacetophenone(100-19-6)Raman

100-19-6(4-Nitroacetophenone)Related Search:

4'-Methoxyacetophenone 4'-Bromoacetophenone 4-Aminoacetophenone 3-Aminoacetophenone 4-Nitrobenzophenone

4'-Methylacetophenone 2-Nitroacetophenone Acetophenone 4'-Hydroxyacetophenone p-Nitrophenylacetonitrile

L-PICEIN 4-Nitrophenylacetic acid 4'-Chloroacetophenone 3-Nitroacetophenone 4'-(Trifluoromethyl)acetophenone

4-NITROPHENYLACETYLENE 4-Nitrobenzyl alcohol 2-BROMO-2'-NITROACETOPHENONE

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AURORA KA-7140 4'-NITROACETOPHENONE 4-NITROACETOPHENONE AKOS BBS-00003219 4'-Nitroacetophenone 1-(4-Nitrophenyl)ethan-1-one p-Nitroacetophenone ORTHO-NITROACETOPHENONE 4''-NITROACETOPHENONE CHLOAMPHENICOL p-Nitroacetophenone,97% 4′-Nitroacetophenone ,98% 1-(4-Nitrophenyl)ethan-1-one, 4-Acetylnitrobenzene p-Nitroacetophenone, 97% 100GR NSC 41590 4'-NITROACETOPHENONE FOR SYNTHESIS 1-Acetyl-4-nitrobenzene 4’-nitro-acetophenon 4-Acetylnitrobenzene 4-Nitrophenylmethylketone Acetophenone,4’-nitro- 1-(4-nitrophenyl)-ethanon Ethanone, 1-(4-nitrophenyl)- Ethanone,1-(4-nitrophenyl)- Methyl4-nitrophenylketone Methyl-p-nitrophenyl ketone methyl-p-nitrophenylketone Methylp-nitrophenylketone p-Acetylnitrobenzene Paranitroacetophenone p-Nitroacetophenon p-Nitrophenyl methyl ketone p-nitrophenylmethylketone Bromo-2&rsquo 4'-Nitroacetophenone, 98%, for synthesis 4'-Nitroacetophenone> 100-19-6 4-Nitroacetophenone 1-(4-NITROPHENYL)ETHAN-1-ONE 1-(4-nitrophenyl)ethanone P-NITROACETOPHENONE Nitroacetophenone PNAP 100-19-6 O2NC6H4COCH3 KETONE Carbonyl Compounds C7 to C8 Building Blocks Ketones Organic Building Blocks C7 to C8 Carbonyl Compounds Chemical Synthesis Organic Building Blocks C7 to C8 Carbonyl Compounds Ketones Aromatic Acetophenones & Derivatives (substituted) Building Blocks 100-19-6