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Myricetin

The source of plant Flavonoids compounds Physicochemical property The antagonism of platelet activating factor (PAF) Hypoglycemic effect Antioxygenation The function of protecting liver Light alcohol poisoning Clinical application
Myricetin
Myricetin
CAS No.
529-44-2
Chemical Name:
Myricetin
Synonyms
MYRISETIN;MYRICETIN;MYRICETOL;NSC 407290;LDN 0014058;Myricetin,95%;CANNABISCETIN;MYRICETIN 95%;CANNABISCETIN hplc;MYRICETIN WITH HPLC
CBNumber:
CB5142262
Molecular Formula:
C15H10O8
Formula Weight:
318.24
MOL File:
529-44-2.mol

Myricetin Properties

Melting point:
>300 °C(lit.)
storage temp. 
Refrigerator
solubility 
ethanol: soluble10mg/mL, clear to very faintly turbid, yellow to very deep greenish-yellow
form 
crystalline
color 
Yellowish Brown
Water Solubility 
Soluble in dimethyl sulfoxide,dimethyl formamide and ethanol. Insoluble in water.
Merck 
14,6332
CAS DataBase Reference
529-44-2(CAS DataBase Reference)

SAFETY

Safety Statements  24/25
WGK Germany  3
RTECS  LK8646000
10

Myricetin price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 476275 Myricetin 529-44-2 25mg $81.5 2017-11-08 Buy
Sigma-Aldrich 05390590 Myricetin primary pharmaceutical reference standard 529-44-2 10mg $296.5 2017-11-08 Buy
TCI Chemical M2131 Myricetin >97.0%(HPLC) 529-44-2 500mg $72 2017-12-01 Buy
TCI Chemical M2131 Myricetin >97.0%(HPLC) 529-44-2 5g $435 2017-12-01 Buy
Alfa Aesar J60450 Myricetin, 98% 529-44-2 10mg $51.3 2017-11-08 Buy

Myricetin Chemical Properties,Uses,Production

The source of plant

Myricetin is a kind of flavonols compounds, which extracted from the bark of myricaceae plant. Waxberry is one of the subtropical fruit trees native to China, and The growth history of wild has been over 7000 years, and artificial cultivation has more than 2000 years. There are very rich resources of the bark of myricaceae in Eastern China, hunan, guangdong, guangxi, guizhou and other regions, but the trimmed discarded arbutus tree branches can be as a large number of plant sources for a long time. But due to reasons such as extraction process, the current study of arbutus pigment mainly comes from the vine tea, source of strawberry tree is very little. And cany tea mainly comes from dihydrogen arbutus pigment and limited resources, and has the limitation to the long-term development and utilization on myricetin.
Red bayberry bark is used as antibacterial and anti-inflammatory drugs, and arbutus pigment and arbutus glucosidethe are contained in the red bayberry bark. At home and abroad in recent years, studies have shown that myricetin has a variety of activities. Antagonism of platelet activating factor(PAF), fall blood sugar function, antioxidation, protect liver function, the solution of light alcohol poisoning, the active ingredient myricetin in red bayberry bark and leaves has the proven pharmacological effects, also has anti-inflammatory, antitumor, resistance mutation, prevention of dental caries, oxidation resistance, elimination of free radicals and other pharmacological activities.
The molecular structural formula of myricetin
The molecular structural formula of myricetin
The above information is collected by Chemicalbook of XiaoNan.

Flavonoids compounds

Myricetin is a kind of flavonoids which extracted from the fruits of arbutus, has scavenging free radicals, antioxidation, antitumor, reduces nerve toxicity, affects lymphocyte activation and proliferation, platelet activating factor, reduces blood sugar, removes alcohol, prevention of alcoholic liver, fatty liver, liver cell deterioration, reduces the incidence of liver cancer, protects liver to protect liver, anti-inflammatory and other functions.
The main functions of myricetin:
1) The role of the antioxidant: myricetin is a kind of very strong antioxidant, and oxidative stress plays a key role in various neurological diseases including ischemia and old age dementia. Myricetin is reducing generation and toxicity of beta amylaseby by conformational change effect. Statistics can be used to progress in the senile dementia.
2)The effect of anti-tumor: Myricetin is a kind of effective carcinogenic chemical control agent.
3) Reduce the nerve toxicity: Myricetin can inhibit to protect neurons induced by glutamate neurotoxicity through different way, thus effectively prevent nerve damage.
4) The influence on lymphocyte activation and proliferation: Myricetin can inhibit activation index expression of CD69 of early T cell, and can suppress lymphocyte proliferation response.
5) The antagonism of platelet activating factor (PAF): The concentration dependence of myricetin outside to inhibit PAF induced WRP gathered and the release of 52HT. At the same time it can obviously inhibit PAF caused by increase of platelet Ca2+. So myricetin has antithrombotic, against myocardial ischemia, improving microcirculation, etc various cardiovascular pharmacological effects.
6) Fall the blood sugar function: myricetin has evident fall on blood sugar function.
7)The function of protect liver:The dihydrogen arbutus pigment can obviously inhibit activities of the serum alanine aminotransferase (ALT) and radix asparagi ammonia enzyme aminotransferase (AST) and reduce serum total bilirubin, having obvious the action of fall enzymes back yellow.

Physicochemical property

Yellow needle crystal (ethanol), melting point is 357 ℃, the maximum absorption wavelength (ethanol) : 375, 255 nm; Soluble in ethanol, methanol, acetone, soluble in hot water, insoluble in chloroform, acetic acid.

The antagonism of platelet activating factor (PAF)

Chen Wenmei and Zang Baoxia wash platelet (WRP) by measuring the rabbit, suggesting that myricetin can significantly inhibit PAF caused by increased platelet Ca2+, and inhibit specificity combination PAF with rabbit platelet receptor. It shows myricetin can inhibit the effects of the PAF, as a new PAF receptor antagonist. So myricetin has antithrombotic, against myocardial ischemia and improve microcirculation and other various cardiovascular pharmacological effects, is expected to be developed for promoting blood circulation to remove blood stasis drugs.

Hypoglycemic effect

Foreign researcher Yoshikawa M on the study of the resistance drug mechanism of diabetes found that myricetin play a role of hyperglycemia. Studies use models about diabetes caused by alloxan model, the high sugar lever mice model caused by epinephrine and glucose, as well as the normal mice. After oral dosing, determination kinds of the model about mice blood sugar levels. Conclusion has the function of hypoglycemic effect in Alloxan diabetic mice and hyperglycemia mice induced by Adrenalin. The treatment effect is good, but had no hypoglycemic effect on the normal mice.Myricetin has good fall blood sugar effect for a variety of animal models, and it is expected to develop fall blood sugar medicine.
Mice caused by different factors such as diabetes, as well as the normal small rat poison, the determination of kinds of the model mice’s blood sugar levels. Result has the function of hypoglycemic effect in Alloxan diabetic mice and hyperglycemia mice induced by Adrenalin, but had no hypoglycemic effect on the normal mice. In addition, they found in further study, myricetin has good fall blood sugar for a variety of animal models, and it is expected to develop fall blood sugar medicine or as diabetes patients using food additives.

Antioxygenation

Studies using Rancimat method determine its antioxidant properties. The results show that the grease is excellent antioxidant, obviously stronger than the synthetic antioxidant BHT (3, 5-tertiary butyl-4-methyl benzene) can be used as natural antioxidant used in grease on higher food preservation. Other studies have suggested myricetin is a kind of very strong antioxidant, oxidative stress plays a key role in various neurological diseases including ischemia and old age dementia.

The function of protecting liver

Myricetin has a protection of liver, reduction enzyme and retreat yellow, strengthen the nonspecific immune function in mice and immunocompromised mice humoral immune function, thus protect liver function.
Zheng-xian zhong, etc can take carbon tetrachloride, D2 galactosamine and isothiocyanate naphthalene ester to acute liver injury in mice model, observe myricetin to play a role of protection for liver damage, And watch the immune enhancement effect on myricetin. Results confirmed that myricetin can significantly reduce carbon tetrachloride, D2 galactosamine and isothiocyanate naphthalene ester to acute liver injury in mice model, which toxins content in serum, reducing the degeneration and necrosis of liver tissue, and enhance mononuclear macrophage phagocytosis and hemolysin content. It Illustrates the myricetin has protection of liver, reduction enzyme and retreat yellow, strengthens the nonspecific immune function in mice and immunocompromised mice humoral immune function, thus protecting liver function, provide reference for the clinical application of myricetin.

Light alcohol poisoning

Zhejiang folk has a useful experiences bubble wine tradition, waxberry wine imported liquor taste, and not easy to intoxicate. Hase-K people in experiments in alcohol agents found myricetin has removed the effects of alcohol poisoning. Later found in the study of the mechanism, the principle of myricetin can reduce alcohol poisoning, mainly protecting the liver, reduce hexanol of liver damage.

Clinical application

The FDA in USA has myricetin widely used in medicine, food, health care products and cosmetics. Foreign health products in American, health care medicine FYI has myricetin as additives which are treatment for the prevention of arthritis and various kinds of inflammation, especially for pregnancy and lactation is more suitable for women and babies. Myricetin with high purity has been widely used in food, medicine and cosmetic fields. As the further study for myricetin of the pharmacological effects, the demand of market of myricetin will increase sharply, The research and development prospect of myricetin are broad.
Myricetin is specialty resources in China. In view of the regional differences, the international on the research of myricetin is just started. In China now only the research of guangxi rattan tea containing myricetin study more, but zhejiang as big provinces is origin of myricetin. The research about the active ingredient for special local economic crops is one of the few. For myricetin, the research is relatively backward. In Ningbo, related companies have begun to development and application of myricetin in preliminary, striving for its industrialization. Liquid could be used in food additives, such as coarse extraction, separation and purifying of crude extract of active ingredients and pharmacological activity research, etc., and further accelerate the speed of traditional Chinese medicine (TCM) modernization in China.

Chemical Properties

brown-yellow to brown-green crystalline powder

Uses

A novel flavanoid compound useful as chemotherapeutic, chemopreventive, and antiangiogenic agent.

Uses

anti-oxidant, anti-inflammatory and anti-neoplastic activity, reverse transcriptase inhibitor

Definition

ChEBI: A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 3', 4', 5, 5' and 7. It has been isolated from the leaves of Myrica rubra and other plants.

Myricetin Preparation Products And Raw materials

Raw materials

Preparation Products


Myricetin Suppliers

Global( 185)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
pegpharm Co., Ltd
0086-512-58984909
0086-512-56727736 sales@pegpharm.com China 1954 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3229 55
ShangHai YuanYe Biotechnology Co., Ltd. 021-61312847 qq:2797782341
021-55068248 2797782341@qq.com China 7590 60
Microherb Inc. +86 (744) 832-8128
QQ:2236179442; Skype:donviez sales@microherb.cn China 48 50
Changsha Staherb Natural Ingredients Co., Ltd. 0731-84213302 13548561509 13875855783 13203131934
0731-85953715 sales18@staherb.cn; sales12@staherb.cn; staherb@staherb.com China 233 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96820 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40398 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 sales@intatrade.de Germany 3588 66
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6019 61
TCI (Shanghai) Development Co., Ltd. 800-988-0390
021-67121385 sales@tcishanghai.com.cn China 22830 81

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