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Nefazodone

CAS No.
83366-66-9
Chemical Name:
Nefazodone
Synonyms
SERZONE;Dutonin;Nefadar;BMY-13754;NEFAZODONE;MJ-13754-1;MJ-13754-I;Nefazodone base;l)-5-ethyl-4-(2-phenoxyethyl)-;Nefazodone (base and/or unspecified salts)
CBNumber:
CB5144862
Molecular Formula:
C25H32ClN5O2
Molecular Weight:
470.01
MDL Number:
MFCD00865396
MOL File:
83366-66-9.mol
MSDS File:
SDS
Last updated:2023-05-04 17:34:43

Nefazodone Properties

Melting point 180-182°C
Boiling point 599.6±60.0 °C(Predicted)
Density 1.23±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ~11 mg/mL at 60 °C
form solid
pka pKa 6.5 (Uncertain)
color white
CAS DataBase Reference 83366-66-9(CAS DataBase Reference)
NCI Dictionary of Cancer Terms nefazodone; Serzone
FDA UNII 59H4FCV1TF
ATC code N06AX06
NIST Chemistry Reference Nefazodone(83366-66-9)

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

Nefazodone price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0003523 NEFAZODONE 95.00% 83366-66-9 1G $800 2021-12-16 Buy
Medical Isotopes, Inc. 12475 NefazodoneHCl 83366-66-9 10mg $845 2021-12-16 Buy
American Custom Chemicals Corporation API0003523 NEFAZODONE 95.00% 83366-66-9 10G $4400 2021-12-16 Buy
Crysdot CD33000073 Nefazodone 95+% 83366-66-9 1g $772 2021-12-16 Buy
Product number Packaging Price Buy
API0003523 1G $800 Buy
12475 10mg $845 Buy
API0003523 10G $4400 Buy
CD33000073 1g $772 Buy

Nefazodone Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Originator

Dutonin,Bristol-Myers Squibb,USA

Uses

A selective serotonin 5-HT2 receptor antagonist. An antidepressant

Definition

ChEBI: Nefazodone is a N-arylpiperazine, a N-alkylpiperazine, a member of triazoles, a member of monochlorobenzenes and an aromatic ether. It has a role as an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic.

brand name

Serzone (Bristol-Myers Squibb).

Therapeutic Function

Antidepressant

Biological Functions

Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α1- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.

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View Lastest Price from Nefazodone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nefazodone pictures 2019-07-06 Nefazodone
83366-66-9
US $1.00 / KG 1G 98% 100KG Career Henan Chemical Co
  • Nefazodone pictures
  • Nefazodone
    83366-66-9
  • US $1.00 / KG
  • 98%
  • Career Henan Chemical Co
3h-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy l)-5-ethyl-4-(2-phenoxyethyl)- BMY-13754 SERZONE MJ-13754-1 NEFAZODONE 2-[3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL]-5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOL-3-ONE HYDROCHLORIDE Nefazodone base 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, Hydrochloride 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)- Nefazodone (base and/or unspecified salts) Dutonin MJ-13754-I 2-[3-[4-(3-Chlorophenyl)piperazino]propyl]-4-(2-phenoxyethyl)-5-ethyl-2H-1,2,4-triazole-3(4H)-one 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one Nefadar 83366-66-9 C25H32ClN5O2 API Intermediates & Fine Chemicals Pharmaceuticals