Cycloguanil Hydrochloride
- CAS No.
- 152-53-4
- Chemical Name:
- Cycloguanil Hydrochloride
- Synonyms
- uaniL;BN 2410;oguaniL;NSC 3074;NSC 3074-d4;Chloroprimidine;Chloroguanide Triazine;Cycloguanil Hydrochloride;Cycloguanil-d4 Hydrochloride;Cycloguanidine hydrochloride
- CBNumber:
- CB51564793
- Molecular Formula:
- C11H14ClN5.ClH
- Molecular Weight:
- 288.181
- MDL Number:
- MFCD00035308
- MOL File:
- 152-53-4.mol
| Melting point | 210-2150C |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| EWG's Food Scores | 1 |
| FDA UNII | 5C8E0L7498 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P | |||||||||
| NFPA 704 |
|
Cycloguanil Hydrochloride price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S392502 | 1-(4-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE HCL AldrichCPR | 152-53-4 | 50MG | $179 | 2024-03-01 | Buy |
| Cayman Chemical | 16861 | Cycloguanil (hydrochloride) ≥95% | 152-53-4 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16861 | Cycloguanil (hydrochloride) ≥95% | 152-53-4 | 10mg | $55 | 2024-03-01 | Buy |
| Cayman Chemical | 16861 | Cycloguanil (hydrochloride) ≥95% | 152-53-4 | 25mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 16861 | Cycloguanil (hydrochloride) ≥95% | 152-53-4 | 50mg | $139 | 2024-03-01 | Buy |
Cycloguanil Hydrochloride Chemical Properties,Uses,Production
Description
Cycloguanil is the active metabolite of the antimalarial prodrug proguanil. Cycloguanil is formed from proguanil by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A in human liver microsomes. It is an inhibitor of dihydrofolate reductase (DHFR; Kis = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes, respectively). It is active against ten P. falciparum field isolates (IC50s = 0.12-1,400 μg/ml). Cycloguanil reduces parasitemia in a mouse model of P. berghei infection (ED50 = 2 mg/kg). It also reduces parasitemia in a rhesus monkey model of P. cynomolgi infection when administered at a dose of 0.3 mg/kg.
Chemical Properties
Crystalline Solid
Uses
Antimalarial drug.
Uses
Labelled antimalarial drug
Definition
ChEBI: Cycloguanil hydrochloride is the hydrochloride salt of cycloguanil. It is an organic molecular entity and a hydrochloride. It contains a cycloguanil.
References
[1] foote s j, galatis d, cowman a f. amino acids in the dihydrofolate reductase-thymidylate synthase gene of plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance[j]. proceedings of the national academy of sciences, 1990, 87(8): 3014-3017.
[2] blakley r l. dihydrofolate reductase[j]. encyclopedia of molecular medicine, 1984.
[3] birkett d j, rees d, andersson t, et al. in vitro proguanil activation to cycloguanil by human liver microsomes is mediated by cyp3a isoforms as well as by s‐mephenytoin hydroxylase[j]. british journal of clinical pharmacology, 1994, 37(5): 413-420.
Cycloguanil Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |