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REVERSE T3

REVERSE T3 Structure
REVERSE T3 structure
CAS No.
5817-39-0
Chemical Name:
REVERSE T3
Synonyms
T3;TRIIODOTHYRONINE;rT3;LIOTHYRONIN;Reverse triiodothyronine;(2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid;L-T3-13C6;REVERSE T3;REVERSE T3;3,3',5'-T3
CBNumber:
CB5221268
Molecular Formula:
C15H12I3NO4
Molecular Weight:
650.97
MDL Number:
MFCD00036864
MOL File:
5817-39-0.mol
MSDS File:
SDS
Last updated:2024-03-15 13:40:52
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REVERSE T3 Properties

Melting point 234-238 °C(lit.)
Boiling point 534.6±50.0 °C(Predicted)
Density 2.387±0.06 g/cm3(Predicted)
Flash point 9℃
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form powder
pka 2.17±0.20(Predicted)
color Pale Beige to Brown
Stability Light Sensitive
InChI InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChIKey HZCBWYNLGPIQRK-LBPRGKRZSA-N
SMILES C(O)(=O)[C@H](CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)N
NCI Dictionary of Cancer Terms T-3; triiodothyronine
FDA UNII 8NZ4Y08T96

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Precautionary statements  P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
Hazard Codes  Xn,T,F
Risk Statements  36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  AY6750000
F  8
HS Code  29379000
NFPA 704
0
3 0

REVERSE T3 price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T-075 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant? 5817-39-0 1mL $135 2024-03-01 Buy
Cayman Chemical 17598 3,3',5'-Triiodo-L-thyronine ≥95% 5817-39-0 5mg $85 2024-03-01 Buy
Cayman Chemical 17598 3,3',5'-Triiodo-L-thyronine ≥95% 5817-39-0 10mg $162 2024-03-01 Buy
Cayman Chemical 17598 3,3',5'-Triiodo-L-thyronine ≥95% 5817-39-0 25mg $380 2024-03-01 Buy
Cayman Chemical 17598 3,3',5'-Triiodo-L-thyronine ≥95% 5817-39-0 50mg $674 2024-03-01 Buy
Product number Packaging Price Buy
T-075 1mL $135 Buy
17598 5mg $85 Buy
17598 10mg $162 Buy
17598 25mg $380 Buy
17598 50mg $674 Buy

REVERSE T3 Chemical Properties,Uses,Production

Description

Either a derivative or precursor of thyroxine. Triiodothyronine increases themetabolic rate and oxygen consumption of animal tissues. Used in biochemical research, medicine (metabolic insufficiency).

Chemical Properties

Beige Powder

Uses

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

Uses

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

Definition

ChEBI: 3,3',5'-triiodo-L-thyronine is a 3,3',5'-triiodothyronine. It is a tautomer of a 3,3',5'-triiodo-L-thyronine zwitterion.

Biological Activity

3,3',5'-triiodo-l-thyronine (reverse t3 or rt3) and 3,5,3'-triiodo-l-thyronine (t3) are the metabolism of thyroxine (t4) [1]. 3,3',5'-triiodo-l-thyronine is thyroid hormone receptors trα and trβ antagonist [1].thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. the actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (trs) and regulation of gene expression. trs have been also involved in adult brain function. in adult mice, trα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].the rt3 was about 1,000-fold less active at the thyroid hormone receptors trα and trβ compared with 3,3',5-triiodo-l-thyronine and commonly described as inactive [1].it has been reported that rt3 activates a native form of trα, trδα1, which lacks a nuclear localization signal and functions in the cytoplasm. through this action, rt3 initiates actin polymerization, particularly in astrocytes and neurons [3].

References

[1] nicod p, burger a, staeheli v, et al. a radioimmunoassay for 3, 3′, 5′-triiodo-l-thyronine in unextracted serum: method and clinical results[j]. the journal of clinical endocrinology & metabolism, 1976, 42(5): 823-829.
[2] bernal j. thyroid hormone receptors in brain development and function[j]. nature clinical practice endocrinology & metabolism, 2007, 3(3): 249-259.
[3] senese r, cioffi f, de lange p, et al. thyroid: biological actions of ‘nonclassical’thyroid hormones[j]. journal of endocrinology, 2014, 221(2): r1-r12.

REVERSE T3 synthesis

59302-19-1
5817-39-0
Synthesis of REVERSE T3 from N-Acetyl-3-iodo-L-tyrosine, Amide

REVERSE T3 Preparation Products And Raw materials

Raw materials

Preparation Products

REVERSE T3 Suppliers

Global( 208)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan senwayer century chemical Co.,Ltd
+undefined-27-86652399 +undefined13627115097 market02@senwayer.com China 874 58
Shenzhen Monkono Technology Co.,Ltd
+86-17063441314 sansbiotech@outlook.com China 677 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 951 58
Wuhan Quanjinci New Material Co.,Ltd. 		+8615271838296 kyra@quanjinci.com China 1532 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15371 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998 sales@czwytech.com CHINA 906 58
Xi'an Kono chem co., Ltd., 		029-86107037 13289246953 info@konochemical.com China 2995 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Supplier Advantage
Wuhan senwayer century chemical Co.,Ltd
58
Shenzhen Monkono Technology Co.,Ltd
58
hebei hongtan Biotechnology Co., Ltd
58
Wuhan Quanjinci New Material Co.,Ltd. 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hangzhou FandaChem Co.,Ltd. 		55
Cangzhou Wanyou New Material Technology Co.,Ltd 		58
Xi'an Kono chem co., Ltd., 		58
Shochem(Shanghai) Co.,Ltd 		58
Standardpharm Co. Ltd. 		58

View Lastest Price from REVERSE T3 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
T3 (Liothyronine sodium) pictures 2024-04-12 T3 (Liothyronine sodium)
5817-39-0
 US $45.00-35.00 / kg 1kg 99.9% 2000kg hebei hongtan Biotechnology Co., Ltd
T3 pictures 2024-03-16 T3
5817-39-0
 US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
T3 pictures 2023-11-29 T3
5817-39-0
 US $45.00 / kg 1kg 0.99 1000000tons Wuhan Quanjinci New Material Co.,Ltd.
  • T3 pictures
  • T3
    5817-39-0
  • US $0.00 / KG
  • 98%+
  • WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
  • T3 pictures
  • T3
    5817-39-0
  • US $45.00 / kg
  • 0.99
  • Wuhan Quanjinci New Material Co.,Ltd.

REVERSE T3 Spectrum

REVERSE T3(5817-39-0)1HNMR

5817-39-0(REVERSE T3)Related Search:

Sodium levothyroxine 3,3',5-Triiodo-L-thyronine Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]- T0901317 T5601640
Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED 4-(4-Hydroxyphenoxy)-3,5-diiodo-benzaldehyde 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID Levothyroxine EP Impurity B Levothyroxine Impurity 16
N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde Levothyroxine O-Methyl Amine Impurity O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine 3,5-Diiodo-4-(p-Methoxyphenoxy)-benzaldehyde
3,5-Diiodo-L-thyronine 3,3',5-TRIIODOTHYROPROPIONIC ACID 3-IODO-L-TYROSINE

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Reverse T3 (3,3',5'-Triiodo-L-Thyronine) L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo- REVERSE T3 L-3,3',5'-TRIIODOTHYRONINE 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution Levothyroxine EP Impurity K 3,3',5'-TRIIODO-L-THYRONINE, THYROID Reverse L-triiodothyronine (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid Reverse T3 3,3',5'-triiodo-L-thyronine free acid Isoliothyronine 3,3’,5-Triiodo-L-thyronine-13C6 3,3’,5-Triiodothyronine-13C6 Liothyronine-13C6 L-T3-13C6 O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine-13C6 T3 (Hormone)-13C6 Tresitope-13C6 Triiodothyronine-13C6 (3,5,3')-TRIIODO-L-THYRONINE (S)-3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-2-aminopropanoic acid triiodothyronine,reverse 3,3′,5′-Triiodo-L-thyronine 3,3′,5′-Triiodo-L-thyronine 3,3′,5′-Triiodo-L-thyronine thyroid horMone analog O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-Tyrosine REVERSE T3 Levothyroxine Impurity 10（Levothyroxine EP Impurity K） Levothyroxine Impurity K Levothyroxine EP Imp K 3, 3', 5'- Triiodothyronine (Solution) Triiodothyronine (L-Liothyronine Reverse Triiodothyronine hydrochloride (Reverse T3) (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyL REVERSE T3 USP/EP/BP 3,3',5'-L-Triiodothyronine 3,3',5'-T3 Alanine,3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-, L- (8CI) Levothyroxine EP Impurity KQ: What is Levothyroxine EP Impurity K Q: What is the CAS Number of Levothyroxine EP Impurity K Q: What is the storage condition of Levothyroxine EP Impurity K Q: What are the applications of Levothyroxine EP Impurity K 6-Tetramethyl-4-piperidinone (2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid T3 LIOTHYRONIN rT3 Reverse triiodothyronine TRIIODOTHYRONINE Triiodothyronine。REVERSE T3 Zebrafish triiodothyronine (T3) ELISA Kit Levothyroxine EP Impurity K (3,3',5'-Triiodo-L-thyronine) Levothyroxine Sodium EP Impurity K Liothyronine Triiodothyronin 5817-39-0 472-61-546 C913C6H12I3NO4 BioChemical Biochemicals and Reagents Amino Acids and Peptides Specialty Synthesis