Linifanib (ABT-869)
- CAS No.
- 796967-16-3
- Chemical Name:
- Linifanib (ABT-869)
- Synonyms
- RG3635;CS-178;ABT-869;AL-39324;Linifanib;Linifanib-d4;ABT-869 5.2G;AL39324,RG3635;Caswell No. 146;ABT-869、AL-39324
- CBNumber:
- CB52464951
- Molecular Formula:
- C21H18FN5O
- Molecular Weight:
- 375.4
- MDL Number:
- MFCD11840918
- MOL File:
- 796967-16-3.mol
| Melting point | 180-183°C (dec.) |
|---|---|
| Boiling point | 542.2±50.0 °C(Predicted) |
| Density | 1.424 |
| storage temp. | -20°C Freezer |
| solubility | DMSO, Methanol |
| pka | 13.30±0.70(Predicted) |
| form | Brown powder. |
| color | Beige |
| NCI Dictionary of Cancer Terms | ABT-869 |
| FDA UNII | CO93X137CW |
| NCI Drug Dictionary | linifanib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H410-H372-H361-H400 |
| Precautionary statements | P273-P391-P501-P273-P391-P501-P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
| HS Code | 2933998090 |
Linifanib (ABT-869) price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13653 | ABT-869 ≥98% | 796967-16-3 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 13653 | ABT-869 ≥98% | 796967-16-3 | 5mg | $99 | 2024-03-01 | Buy |
| Cayman Chemical | 13653 | ABT-869 ≥98% | 796967-16-3 | 10mg | $139 | 2024-03-01 | Buy |
| TRC | L466450 | Linifanib | 796967-16-3 | 25mg | $295 | 2021-12-16 | Buy |
| TRC | L466450 | Linifanib | 796967-16-3 | 50mg | $535 | 2021-12-16 | Buy |
Linifanib (ABT-869) Chemical Properties,Uses,Production
Chemical Properties
Beige Solid
Uses
Linifanib (ABT 869) is an oral tyrosine kinase inhibitor with antineoplasic activity. As a dual inhibitor, Linifanib, is being tested on several different cancers.
Uses
Linifanib (ABT-869) is a novel, potent ATP-competitive RTK inhibitor for KDR, CSF-1R, Flt-1, Flt-3 and PDGFRβ with IC50 of 4 nM, 3 nM, 3 nM, 3 nM, and 66 nM respectively.
Definition
ChEBI: A member of the class of ureas that is urea in which one of the nitrogens is substituted by a 2-fluoro-5-methylphenyl group, while the other nitrogen is substituted by a p-(3-amino-1H-indazol-4-yl)phenyl group. It is a poten , selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinases.
Biological Activity
linifanib (abt-869) is an effective atp-competitive tyrosine kinase inhibitor against the platelet-derived growth factor (pdgf) receptor and the vascular endothelial growth factor receptor (vegfr) families, including constitutively active fms-like receptor tyrosine kinase 3 (flt3) [1][2]. it is of ic50 values of 0.55 nmol/l and 6 μmol/l to the cell growth in ba/f3 flt3 itd mutant cells and in ba/f3 flt3 wt cells, respectively [1].flt3 is important in controlling the proliferation and differentiation of hematopoietic cells. patients with acute myeloid leukemia (aml) showed activating mutations in flt3. these mutations caused abnormal cell proliferation [1].linifanib at a concentration of 10 nmol/l induced apoptosis in internal tandem duplication (itd) mutant cells, but showed no effect in wt cells. treatment with linifanib did not differentiate wt cells from flt3 mutant cells with mutation at d835v, in inhibiting proliferation or reducing cell viability. in ba/f3 flt3 itd cell lines, linifanib at a concentration of 10 nmol/l, effectively inhibited the phosphorylation of flt3. 10 nmol/l linifanib reduced the phosphorylation of akt at ser473 [1].daily orally treatment with linifanib by gavage in nod/scid mice with itd mutant cell decreased the leukemia progression rate compared with the control. on day 7, itd mutant cells showed rapid progression in control mice, whereas linifanib-treated mice showed no detectable disease. in addition, daily linifanib-treated mice with itd mutant cells showed significantly longer (p < 0.01) survival duration than control mice with itd mutant cells only [1].
target
VEGFR1/FLT1
storage
Store at -20°C
References
[1]. jenny e. hernandez-davies, joan p. zape, elliot m. landaw, et al. the multitargeted receptor tyrosine kinase inhibitor linifanib (abt-869) induces apoptosis through an akt and glycogen synthase kinase 3β–dependent pathway. mol. cancer ther., 2011, 10(6):949-59.
[2]. joyce e. ohm, michael r. shurin, clemens esche, et al. effect of vascular endothelial growth factor and flt3 ligand on dendritic cell generation in vivo. journal of immunology, 1999, 163:3260-3268.
Linifanib (ABT-869) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29322 | 58 |
View Lastest Price from Linifanib (ABT-869) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | Linifanib (ABT-869)
796967-16-3
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
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- Linifanib (ABT-869)
796967-16-3
- US $1.00 / KG
- 99%
- Career Henan Chemical Co