ChemicalBook >> CAS DataBase List >>LX-4211
LX-4211
- CAS No.
- 1018899-04-1
- Chemical Name:
- LX-4211
- Synonyms
- Sotagliflozin;β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S)-;(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP 802034;LX421;LX-4211;CS-1853;SOTA-009;LP 802034;EOS-61381;LX4211/LX-4211
- CBNumber:
- CB52516025
- Molecular Formula:
- C21H25ClO5S
- Molecular Weight:
- 424.94
- MDL Number:
- MFCD22493506
- MOL File:
- 1018899-04-1.mol
Last updated:2024-03-14 18:29:10
| Boiling point | 607.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
DMSO:84.0(Max Conc. mg/mL);197.67(Max Conc. mM) Ethanol:17.0(Max Conc. mg/mL);40.01(Max Conc. mM) |
| pka | 12.87±0.70(Predicted) |
| form | Powder |
| FDA UNII | 6B4ZBS263Y |
| NCI Drug Dictionary | sotagliflozin |
| ATC code | A10BK06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H351-H373 | |||||||||
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P260-P314-P501 | |||||||||
| NFPA 704 |
|
LX-4211 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19141 | Sotagliflozin ≥98% | 1018899-04-1 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19141 | Sotagliflozin ≥98% | 1018899-04-1 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 19141 | Sotagliflozin ≥98% | 1018899-04-1 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 19141 | Sotagliflozin ≥98% | 1018899-04-1 | 25mg | $573 | 2024-03-01 | Buy |
| ApexBio Technology | A3567 | LX-4211 | 1018899-04-1 | 5mg | $165 | 2021-12-16 | Buy |
LX-4211 Chemical Properties,Uses,Production
Uses
Sotagliflozin is used for the treatment of patients with type 1 diabetes mellitus.
Clinical Use
Two of the current SGLT-2 inhibitors (canagliflozin and LX-4211) have effects on SGLT-1. LX-4211 is a dual SGLT1/2 inhibitor and higher doses of canagliflozin transiently inhibit SGLT-1 in the gut due to high canagliflozin concentrations within the intestinal lumen during the period of drug absorption.
Synthesis
Sotagliflozin is a dual SGLT-1/SGLT-2 inhibitor which is currently under development by Lexicon Pharmaceuticals (phase III). It follows a similar strategy to ertugliflozin, i.e. aryl addition on an acyclic precursor. The synthesis starts from L-xylose 53, and the aryl moiety (same aryl moiety as for dapagliflozin) is introduced on an amide derivative (morpholine amide 54) via Grignard addition. A subsequent transformation leads to the sotagliflozin (Scheme 10). The overall yield of the synthesis is around 30%.
Sotagliflozin synthesis
Synthesis of LX-4211 from β-L-Xylopyranoside, Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-, 2,3,4-triacetate,(5S)-
LX-4211 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 246)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 359 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Related articles
- How to synthesize Sotagliflozin?
- Sotagliflozin (LX-4211) is a dual sodium-glucose co-transporter-2 and 1 (SGLT2/1) inhibitor for the treatment of both type 1 (....
- Jan 16，2024
View Lastest Price from LX-4211 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-15 | Sotagliflozin;LX-4211
1018899-04-1
|
US $0.00-0.00 / kg | 1kg | 99 | 500kg | Shanghai Affida new material science and technology center | |
 |
2024-01-04 | Sotagliflozin,LX-4211, LP-802034, LX4211, LP802034
1018899-04-1
|
US $0.00-0.00 / kg | 1kg | 99%，single impurity＜0.1 | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2023-11-01 | Sotagliflozin; LX-4211
1018899-04-1
|
US $5500.00 / g | 1g | 99.0%min， single impurity：0.5%min | 500kg | Hangzhou ICH Biofarm Co., Ltd |
-
- Sotagliflozin;LX-4211
1018899-04-1
- US $0.00-0.00 / kg
- 99
- Shanghai Affida new material science and technology center
-
- Sotagliflozin,LX-4211, LP-802034, LX4211, LP802034
1018899-04-1
- US $0.00-0.00 / kg
- 99%，single impurity＜0.1
- Nanjing Fred Technology Co., Ltd
-
- Sotagliflozin; LX-4211
1018899-04-1
- US $5500.00 / g
- 99.0%min， single impurity：0.5%min
- Hangzhou ICH Biofarm Co., Ltd
1018899-04-1(LX-4211)Related Search:
LX-4211
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(Methylthio)tetrahydro-2H-pyran-3,4,5-triol
(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-1-thio-beta-L-xylopyranoside
LX4211/LX-4211
LP 802034
LX4211 - L10525
LX-4211 (sotagliflozin)
LX-4211, >=98%
Zabofloxacin Hydrochloride
Sotagliflozin,0.99
β-L-Xylopyranoside, methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-, (5S)-
LX4211/Sotagliflozin-API
Sotagliflozin, must
LX4211, 98%, a potent dual SGLT2/1 inhibitor
Sotagliflozin lx4211
LX421
SOTA-009
(2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol
EOS-61381
LX4211; LX 4211; LX4211; LX 4211
CS-1853
(2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(methylsulfanyl)tetrahydro-2-H-pyran-3,4,5-triol
Sotagliflozin
(5S)-Methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-beta-L-xylopyranoside Sotagliflozin LP 802034
β-L-Xylopyranoside,methyl5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-,(5S)-
UNII-6B4ZBS263Y
Bifeprunox Impurity 42
Sotagliflozin,LX-4211, LP-802034, LX4211, LP802034
1018899-04-1
C21H25ClO5S
C21H25O5ClS