KGN
- CAS No.
- 4727-31-5
- Chemical Name:
- KGN
- Synonyms
- KGN;CS-612;100822;Kartogenin;KGN USP/EP/BP;Kartogenin(KGN);4'-Phenylphthalanilic Acid;n-Biphenyl-4-yl-phthalamic acid;4′-Phenyl-phthalanilic acid (8CI);2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid
- CBNumber:
- CB52622751
- Molecular Formula:
- C20H15NO3
- Molecular Weight:
- 317.34
- MDL Number:
- MFCD00560510
- MOL File:
- 4727-31-5.mol
- MSDS File:
- SDS
| Melting point | 272 °C |
|---|---|
| Boiling point | 464.4±38.0 °C(Predicted) |
| Density | 1.289±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: >15mg/mL |
| form | powder |
| pka | 3.45±0.36(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| InChIKey | SLUINPGXGFUMLL-UHFFFAOYSA-N |
| FDA UNII | Q93BBN11CP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319-H410 | |||||||||
| Precautionary statements | P273-P305+P351+P338-P501 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-36-50/53 | |||||||||
| Safety Statements | 60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2916310090 | |||||||||
| NFPA 704 |
|
KGN price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0370 | Kartogenin ≥98% (HPLC) | 4727-31-5 | 5mg | $110 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0370 | Kartogenin ≥98% (HPLC) | 4727-31-5 | 25mg | $441 | 2024-03-01 | Buy |
| Cayman Chemical | 11826 | Kartogenin ≥98% | 4727-31-5 | 5mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 11826 | Kartogenin ≥98% | 4727-31-5 | 10mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 11826 | Kartogenin ≥98% | 4727-31-5 | 25mg | $261 | 2024-03-01 | Buy |
KGN Chemical Properties,Uses,Production
Description
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-
Uses
Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.
Biochem/physiol Actions
Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
storage
+4°C
References
1) Johnson et al. (2012), A stem cell-based approach to cartilage repair; Science, 336 717
KGN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21149 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from KGN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid pictures](https://img.chemicalbook.com/ProductImageEN/2019-9/Small/52a74ed7-749b-4502-bb97-fa685facc639.jpg) |
2019-09-06 | 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid
4727-31-5
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
-
- 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid
4727-31-5
- US $1.00 / KG
- 98%
- Career Henan Chemical Co