AACOCF3
- CAS No.
- 149301-79-1
- Chemical Name:
- AACOCF3
- Synonyms
- BPK;ATK;AGMX1;AATFMK;PSCTK1;AACOCF;AACOCF3;Arach-CF3;BTK active human;B cell progenitor kinase
- CBNumber:
- CB5266861
- Molecular Formula:
- C21H31F3O
- Molecular Weight:
- 356.47
- MDL Number:
- MFCD00236427
- MOL File:
- 149301-79-1.mol
- MSDS File:
- SDS
| Boiling point | 421.7±45.0 °C(Predicted) |
|---|---|
| Density | 0.981±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >5 mg/mL |
| form | liquid |
| color | yellow |
| Stability | Light Sensitive |
| EWG's Food Scores | 1 |
| FDA UNII | 00XIW1CR0F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
AACOCF3 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A231 | Arachidonyl trifluoromethyl ketone oil, ≥97% (NMR) | 149301-79-1 | 5mg | $482 | 2024-03-01 | Buy |
| Cayman Chemical | 62120 | Arachidonyl Trifluoromethyl Ketone ≥98% | 149301-79-1 | 5mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 62120 | Arachidonyl Trifluoromethyl Ketone ≥98% | 149301-79-1 | 1mg | $8 | 2021-12-16 | Buy |
| Cayman Chemical | 62120 | Arachidonyl Trifluoromethyl Ketone ≥98% | 149301-79-1 | 10mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 62120 | Arachidonyl Trifluoromethyl Ketone ≥98% | 149301-79-1 | 50mg | $433 | 2024-03-01 | Buy |
AACOCF3 Chemical Properties,Uses,Production
Uses
Arachidonyl trifluoromethyl ketone (AACOCF3) has been used as a anandamide degradation inhibitor to study its effects in primary astrocyte cultures.
Definition
ChEBI: A fatty acid derivative that is arachidonic acid in which the OH part of the carboxy group has been replaced by a trifluoromethyl group
Biological Activity
Inhibitor of cytosolic (85 kDa) phospholipase A 2 . Also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro .
Biochem/physiol Actions
Arachidonyl trifluoromethyl ketone (AACOCF3) plays a role in the inhibition of 12-hydroxyeicosatetraenoic acid (12-HETE) and thromboxane B2 produced by the platelets.
storage
-20°C (desiccate)
References
[1]. ackermann ej, conde-frieboes k, dennis ea. inhibition of macrophage ca(2+)-independent phospholipase a2 by bromoenol lactone and trifluoromethyl ketones. j biol chem, 1995, 270(1): 445-450.
[2]. riendeau d, guay j, weech pk, et al. arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kda phospholipase a2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. j biol chem, 1994, 269(22): 15619-15624.
[3]. malaviya r, ansell j, hall l, et al. targeting cytosolic phospholipase a2 by arachidonyl trifluoromethyl ketone prevents chronic inflammation in mice. eur j pharmacol, 2006, 539(3): 195-204.
AACOCF3 Preparation Products And Raw materials
Raw materials
Preparation Products
AACOCF3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18739 | 57 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3419 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 9998 | 58 | |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9287 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |