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2-METHOXYESTRADIOL

CAS No.
362-07-2
Chemical Name:
2-METHOXYESTRADIOL
Synonyms
2-Methoxy 17β-Estradiol;2-ME2;Panzem;2-MeOE2;NSC 659853;Methoxy estradiol;7-Methoxyestradiol;2-METHOXYESTRADIOL;2-METHOXYOESTRADIOL;2-Methoxy-β-estradiol
CBNumber:
CB5268052
Molecular Formula:
C19H26O3
Molecular Weight:
302.41
MDL Number:
MFCD00010489
MOL File:
362-07-2.mol
Last updated:2024-03-27 16:59:26

2-METHOXYESTRADIOL Properties

Melting point 188-190°C
Boiling point 464.4±45.0 °C(Predicted)
Density 1.178±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility DMSO: 10 mg/mL
form crystalline
pka 10.29±0.60(Predicted)
color light yellow
λmax 286nm(EtOH)(lit.)
InChIKey CQOQDQWUFQDJMK-SSTWWWIQSA-N
CAS DataBase Reference 362-07-2(CAS DataBase Reference)
NCI Dictionary of Cancer Terms 2-methoxyestradiol
FDA UNII 6I2QW73SR5
NCI Drug Dictionary 2-methoxyestradiol

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319-H335-H350-H360-H372-H410
Precautionary statements  P273-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338
Hazard Codes  T,Xi,N
Risk Statements  23/24/25-36/37/38-48-61-60-46-45-51/53
Safety Statements  22-26-36/37/39-45-53-36-61
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS  KG7537500
HS Code  2937.23.5050
NFPA 704
0
4 0

2-METHOXYESTRADIOL price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 454180 2-Methoxyestradiol 362-07-2 10mg $113 2024-03-01 Buy
Sigma-Aldrich 454180 2-Methoxyestradiol 362-07-2 50mg $417 2024-03-01 Buy
TCI Chemical M2530 2-Methoxy-β-estradiol >97.0%(GC) 362-07-2 25mg $44 2024-03-01 Buy
TCI Chemical M2530 2-Methoxy-β-estradiol >97.0%(GC) 362-07-2 100mg $117 2024-03-01 Buy
Cayman Chemical 13021 2-Methoxyestradiol ≥95% 362-07-2 5mg $31 2024-03-01 Buy
Product number Packaging Price Buy
454180 10mg $113 Buy
454180 50mg $417 Buy
M2530 25mg $44 Buy
M2530 100mg $117 Buy
13021 5mg $31 Buy

2-METHOXYESTRADIOL Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

2-Methoxyestradiol depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. Phase 2.

Uses

A natural metabolite of 17?Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule a

Uses

A natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly

Uses

2-Methoxy 17β-Estradiol is a natural metabolite of 17β-Estradiol which is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. 2-Methoxy 17β-Estradiol binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.

Uses

2-Methoxyestradiol is a tubulin polymerization inhibitor and also decreases HIF-1 activity.

Definition

ChEBI: A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.

Biological Activity

Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

2-METHOXYESTRADIOL Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 244)Suppliers
Supplier Tel Email Country ProdList Advantage
Hong Kong Excellence Biotechnology Co., Ltd.
+86-86-18838029171 +8618126314766 ada@sh-teruiop.com China 892 58
Sigma Audley
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Hebei Kangcang new material Technology Co., LTD
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Shanghai Aosiris new Material Technology Co., LTD
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career henan chemical co
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18871490254 linda@hubeijusheng.com CHINA 28180 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050 sean.lv@synzest.com China 323 58

View Lastest Price from 2-METHOXYESTRADIOL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methoxyestradiol pictures 2024-03-29 2-Methoxyestradiol
362-07-2
US $20.00-10.00 / kg 1kg 98% 20 Hebei Kangcang new material Technology Co., LTD
2-Methoxyestradiol pictures 2024-03-29 2-Methoxyestradiol
362-07-2
US $9.00-60.00 / g 10g 99% 10 tons Hebei Kangcang new material Technology Co., LTD
2-METHOXYESTRADIOL pictures 2024-03-27 2-METHOXYESTRADIOL
362-07-2
US $3.00-1.00 / kg 1kg 99.9% 10 tons Shanghai Aosiris new Material Technology Co., LTD
  • 2-Methoxyestradiol pictures
  • 2-Methoxyestradiol
    362-07-2
  • US $20.00-10.00 / kg
  • 98%
  • Hebei Kangcang new material Technology Co., LTD
  • 2-Methoxyestradiol pictures
  • 2-Methoxyestradiol
    362-07-2
  • US $9.00-60.00 / g
  • 99%
  • Hebei Kangcang new material Technology Co., LTD
  • 2-METHOXYESTRADIOL pictures
  • 2-METHOXYESTRADIOL
    362-07-2
  • US $3.00-1.00 / kg
  • 99.9%
  • Shanghai Aosiris new Material Technology Co., LTD
2-METHOXYESTRADIOL \ INHIBITOR OF CELL P ROLIFERATION AND ANGIOGENESIS 2-METHOXY-OESTRADIOL-(17BETA),(13S,17S)-2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL 2-Hydroxyestradiol 2-Methyl Ether 2-Methoxy-17b-estradiol 2-Methoxyestra-1,3,5(10)-triene-3,17b-diol NSC 659853 Panzem 2-methoxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol 2-METHOXYOESTRADIOL 2-METHOXYESTRADIOL 98+% 2-METHOXY-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL (17)-2-Methoxy-estra-1,3,5(10)-triene-3,17-diol 2-Methoxy-17-estradiol 2-Methoxyestra-1,3,5(10)-triene-3,17-diol (17B)-2-METHOXYESTRA-1,3,5(10)-TRIENE-3,17-DIOL 2-Methoxy-beta-estradiol 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether 2-MeOE2 2-methoxy-17beta-estradiol 2-methoxy-beta-oestradiol 1,3,5(10)-Estratriene-2,3,17β-triol 2-methyl ether, 2-Methoxy-estra-1,3,5(10)-triene-3,17β-diol 1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether, 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether, 2-Hydroxyestradiol 2-methyl ether, 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene (17β)-2-Methoxyestradiol 17β-2-Methoxyestradiol 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene 7-Methoxyestradiol 2-Methoxyestradiol,1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether, 2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether, 2-Hydroxyestradiol 2-methyl ether, 3,17β-Dihydroxy-2-methoxy-1,3,5(10)-es 2-Methoxy-[13C,2H3]-estradiol 2-ME2 2-Methoxyestradiol(2-MeOE2) (8R,9S,13S,14S,17S)-2-Methoxy-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol 2,3,17BETA-TRIHYDROXY-1,3,5[10]-ESTRATRIENE 2-METHYL ETHER 3,17BETA-DIHYDROXY-2-METHOXY-1,3,5[10]-ESTRATRIENE 2-METHOXY-3,17BETA-DIHYDROXYESTRA-1,3,5(10)-TRIENE 2-METHOXY-ESTRA-1,3,5(10)-TRIENE-3,17BETA-DIOL 2-METHOXYESTRADIOL 1,3,5(10)-ESTRATRIENE-2,3,17BETA-TRIOL 2-METHYL ETHER 1,3,5[10]-ESTRATRIENE-2,3,17-TRIOL 2-METHYL ETHER 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER 2-Methoxyestradiol (NSC-659853) 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem 2-Methoxy-β-estradiol> Methoxy estradiol Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17β)- 2-METHOXYESTRADIOL USP/EP/BP 2-Methoxyestradiol (2MeOE2, NSC659853, 2ME2) 362-07-2 2-METHOXYESTRADIOL 2-Methoxy-β-estradiol 2-Methoxy 17β-Estradiol 2-Methoxy-beta-estradiol 2-Methoxyestradiol 1, 3, 5(10)-ESTRATRIEN-2, 3, 17β-TRIOL 2-METHYL ETHER (17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol 362-07-2 363-07-2 Steroid Hormones Other Steroid Products META - METH Hormones