tert-Butyl 3-oxoazetidine-1-carboxylate
- CAS No.
- 398489-26-4
- Chemical Name:
- tert-Butyl 3-oxoazetidine-1-carboxylate
- Synonyms
- 1-BOC-3-AZETIDINONE;N-Boc-3-azetidinone;N-Boc-Azetidin-3-one;3-OXO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-Butyl 3-Ox;Baricitinib-011;1-Boc azitidone;N-boc-3-azetidine;1-Boc-3-azetidione;1-Boc-3-acetidinone
- CBNumber:
- CB5282384
- Molecular Formula:
- C8H13NO3
- Molecular Weight:
- 171.19
- MDL Number:
- MFCD01861741
- MOL File:
- 398489-26-4.mol
- MSDS File:
- SDS
| Melting point | 47-51 °C |
|---|---|
| Boiling point | 251.3±33.0 °C(Predicted) |
| Density | 1.174±0.06 g/cm3(Predicted) |
| Flash point | 102 °C |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Sparingly), Dichloromethane (Slightly) |
| pka | -1.99±0.20(Predicted) |
| form | Crystalline Powder |
| color | White to off-white |
| Sensitive | Moisture Sensitive/Stench |
| InChI | InChI=1S/C8H13NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h4-5H2,1-3H3 |
| InChIKey | VMKIXWAFFVLJCK-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CC(=O)C1 |
| CAS DataBase Reference | 398489-26-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| RIDADR | UN 3335 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
tert-Butyl 3-oxoazetidine-1-carboxylate price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 696315 | 1-Boc-3-azetidinone 97% | 398489-26-4 | 1g | $97.1 | 2024-03-01 | Buy |
| TCI Chemical | B3988 | 1-(tert-Butoxycarbonyl)-3-azetidinone >98.0%(GC) | 398489-26-4 | 1g | $50 | 2024-03-01 | Buy |
| TCI Chemical | B3988 | 1-(tert-Butoxycarbonyl)-3-azetidinone >98.0%(GC) | 398489-26-4 | 5g | $145 | 2024-03-01 | Buy |
| Alfa Aesar | H50826 | 1-Boc-3-azetidinone, 95% | 398489-26-4 | 250mg | $51.8 | 2021-12-16 | Buy |
| Alfa Aesar | H50826 | 1-Boc-3-azetidinone, 95% | 398489-26-4 | 1g | $201 | 2021-12-16 | Buy |
tert-Butyl 3-oxoazetidine-1-carboxylate Chemical Properties,Uses,Production
Chemical Properties
White to light brown solid
Uses
1-Boc-3-azetidinone can be used for the preparation of antibacterial aminoglycoside analogs.
Uses
tert-Butyl 3-oxoazetidine-1-carboxylate(1-Boc-3-azetidinone) is a currently common organic intermediate. It is a key intermediate for preparing various medicaments. It can be used for preparing Janus kinase 3(JAKS), which is a useful target for immunosuppression and transplant rejection, and can be used for treating inflammatory disorders, autoimmune disorders, cancer and other diseases; also useful in the preparation of a second class of HCV protease inhibitors useful in the treatment of HCV genotype 1 infection; can also be used for preparing novel aminoglycoside compounds with antibacterial activity; bicyclic himbacine (himbacine) derivatives can be prepared which are useful as antagonists of the protease activated receptor-1 (PAR-1) and are predicted to be cannabis (CB2) receptor inhibitors, useful for the treatment of secondary prevention of Acute Coronary Syndrome (ACS), myocardial infarction or thrombotic stroke or peripheral arterial disease; bicyclic azacyclobenzylamine derivatives, such as pyridopyrimidines, can be prepared that modulate the activity of phospho-inositol 3-kinase (P13K) and are useful in the treatment of diseases associated with P13K, including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
General Description
tert-Butyl 3-oxoazetidine-1-carboxylate is moisture sensitive and incompatible with oxidizing agents. This chemical can cause skin irritation and severe eye irritation.
Synthesis
The traditional preparation method of tert-Butyl 3-oxoazetidine-1-carboxylate is mainly to oxidize the hydroxyl on an aza ring into ketone. For example: 3-azetidinium alkoxide, di-tert-butyl dicarbonate and sodium bicarbonate in dioxane: stirring the mixture of water for 15 hours to obtain 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethylethyl ester; dissolving 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethyl ethyl ester in ethanedioyl chloride and dichloromethane, adding DMSO and triethylamine, stirring at room temperature for 15 hours to obtain tert-Butyl 3-oxoazetidine-1-carboxylate.
tert-Butyl 3-oxoazetidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Jinli Pharmaceutical Co.,Ltd | +86-21-57256005 +86-15921811235 | chang@shjlchem.com | China | 20 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Lianhe Aigen Pharmatech Co.,Ltd. | +86-18918657159 +86-18918657159 | sales-Aigen@lianhetech.com | China | 305 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| AB PharmaTech,LLC | 323-480-4688 | United States | 989 | 55 |
View Lastest Price from tert-Butyl 3-oxoazetidine-1-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-28 | Tert-Butyl 3-oxoazetidine-1-carboxylate
398489-26-4
|
US $0.00 / KG | 25KG | 96% | Inquiry | PNP Biotech Co. Ltd | |
 |
2024-02-26 | Tert-butyl 3-oxoazetidine-1-carboxylate
398489-26-4
|
US $0.00-0.00 / kg | 1kg | 98% | Kgs | BTC Nantong Pharmaceuticals Technology Co.,Ltd | |
 |
2023-12-29 | Tert-butyl 3-oxoazetidine-1-carboxylate
398489-26-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd |
-
- Tert-Butyl 3-oxoazetidine-1-carboxylate
398489-26-4
- US $0.00 / KG
- 96%
- PNP Biotech Co. Ltd
-
- Tert-butyl 3-oxoazetidine-1-carboxylate
398489-26-4
- US $0.00-0.00 / kg
- 98%
- BTC Nantong Pharmaceuticals Technology Co.,Ltd
-
- Tert-butyl 3-oxoazetidine-1-carboxylate
398489-26-4
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
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