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alkaloid Toxicity
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Nicotine Properties

Melting point:
-80 °C
-166 º (c=neat)
Boiling point:
243-248 °C
1.010 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.5265(lit.)
Flash point:
215 °F
storage temp. 
ethanol: 50 mg/mL
8.02(at 25℃)
Water Solubility 
Air Sensitive & Hygroscopic
CAS DataBase Reference
54-11-5(CAS DataBase Reference)
NIST Chemistry Reference
EPA Substance Registry System
Pyridine, 3-[(2S)-1-methyl-2-pyrrolidinyl]- (54-11-5)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+,N,Xn,F,Xi,T
Risk Statements  25-27-51/53-36-20/21/22-11-36/37/38-39/23/24/25-23/24/25-59-48/20-40-36/38-24-20/22-63
Safety Statements  7-16-36/37-45-61-36-26-37/39-59
RIDADR  UN 1654 6.1/PG 2
WGK Germany  3
RTECS  QS5250000
HazardClass  6.1
PackingGroup  II
Hazardous Substances Data 54-11-5(Hazardous Substances Data)
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P262 Do not get in eyes, on skin, or on clothing.
P321 Specific treatment (see … on this label).
P405 Store locked up.

Nicotine price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical N0079 Nicotine >95.0%(GC)(T) 54-11-5 25mL $50 2017-12-01 Buy
TCI Chemical N0079 Nicotine >95.0%(GC)(T) 54-11-5 100mL $140 2017-12-01 Buy
Alfa Aesar A12398 (S)-(-)-Nicotine, 99% 54-11-5 100g $212 2017-11-08 Buy
Alfa Aesar A12398 (S)-(-)-Nicotine, 99% 54-11-5 25g $61 2017-11-08 Buy
TCI Chemical N0079 Nicotine >95.0%(GC)(T) 54-11-5 500mL $455 2017-12-01 Buy

Nicotine Chemical Properties,Uses,Production


Nicotine is the substance in tobacco, nicotine content of tobacco because there are different species and origin, alkali content of tobacco each part is different. Cigarette factory scraps (tobacco powder) containing about 1% to 2% of the nicotine, tobacco stems and ribs smoke nicotine containing about 1% or so, people smoked cigarette contains nicotine amounted to about 3%. Pure nicotine is a colorless, oily liquid, miscible with water below 60 ℃, hydrate, more than 210 ℃ also miscible with water. Unstable nature, likely to be volatile, soluble in water and organic solvents. Nicotine is an alkaloid, so all properties of a base, to a compound made of salts and acids. In case of light and air turn brown and sticky, there is the odd smell and strong irritant.


Pure nicotine for people, livestock highly toxic rat oral LD50 of 50~60mg/kg, rabbit acute percutaneous LD5050mg/kg. Rabbit acute percutaneous LD50 for 50~60mg/kg, rabbit acute oral LD50 of 50mg/kg. Based on China's pesticide toxicity grading standards, is a highly toxic pesticides. However, because of volatile and rapidly decompose in air and light, and therefore can still be used to control pests on crops. Rapidly absorbed through the skin, inhalation and dermal exposure to toxic people. Toxic to birds. Young steelhead LC504mg/L, toxic to bees, but there insecticide effect. D. Pulex LC50 of 0.24mg/L. Fish and shellfish toxicity, mild injury to crops.

Chemical Properties

Yellow Liquid


Naturally-occuring isomer


Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.


(S)-(-)-Nicotine is a prototype nicotinic acetylcholine receptor agonist. (S)-(-)-Nicotine is the naturally occurring isomer. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.


ChEBI: An optically active form of nicotine having S-configuration.

General Description

Liquids. Toxic by inhalation, ingestion, and skin absorption. More dense than water. Flash points usually below 140°F. Contact may irritate skin, eyes, and mucous membranes. If available, obtain the technical name of the material from the shipping papers and contact CHEMTREC, (800-424-9300) for specific response information.

Air & Water Reactions

Flammable. Slightly soluble in water.

Reactivity Profile

An alkaloid produced from tobacco. Colorless, oily liquid, combustible, highly toxic. When heated to decomposition L-Nicotine emits very toxic fumes of carbon monoxide and oxides of nitrogen [Lewis, 3rd ed., 1993, p. 919].

Health Hazard

L-Nicotine is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lbs.) person. It may be assumed that ingestion of 40-60 mg of nicotine is lethal to humans. There is fundamental difference between acute toxicity from use of nicotine as insecticide or from ingestion, and chronic toxicity that may be caused by prolonged exposure to small doses as occurs in smoking. Maternal smoking during pregnancy is associated with increased risk of spontaneous abortion, low birth weight and still-birth. Nicotine was found as a co-carcinogen in animals.

Fire Hazard

There is a moderate explosion hazard when exposed to heat or flame. When heated to decomposition, L-Nicotine emits nitrogen oxides, carbon monoxide and other highly toxic fumes. Avoid oxidizing materials. Stable under normal conditions. Avoid heat or flames.

Nicotine Preparation Products And Raw materials

Raw materials

Preparation Products

Nicotine Suppliers

Global( 189)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545 CHINA 514 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3229 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20809 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32766 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 CHINA 804 55
Hubei Heno Biological Engineering Co.,Ltd 0755-23211157 18565668426
0718-8222016 China 5 58
Hangzhou J&H Chemical Co., Ltd. +86-0571-87396432
+86-0571-87396431 China 14049 53
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 China 15940 69
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 China 30309 84
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078,021-50426030
86-021-50426522,50426273 China 10089 60

View Lastest Price from Nicotine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-03-05 L-Nicotine
US $200.00 / KG 1KG 99% 100000KG Hubei XinRunde Chemical Co., Ltd

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