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ChemicalBook >> CAS DataBase List >> L-Nicotine


alkaloid Toxicity

CAS No. 54-11-5
Chemical Name: L-Nicotine
Synonyms: NO-FID;Emo-Nik;Nic-Sal;Tendust;Nicolan;Niconil;Tabazur;ent3,424;fluxmaag;Mach-Nic
CBNumber: CB5293753
Molecular Formula: C10H14N2
Formula Weight: 162.23
MOL File: 54-11-5.mol
L-Nicotine Property
Melting point : -80 °C
alpha : -166 º (c=neat)
Boiling point : 243-248 °C
density : 1.010 g/mL at 20 °C(lit.)
refractive index : n20/D 1.5265(lit.)
Fp : 215 °F
storage temp. : 2-8°C
solubility : ethanol: 50 mg/mL
form : liquid
pka: 8.02(at 25℃)
color : yellow
Water Solubility : MISCIBLE
Sensitive : Air Sensitive & Hygroscopic
Merck : 14,6524
BRN : 82109
CAS DataBase Reference: 54-11-5(CAS DataBase Reference)
NIST Chemistry Reference: 3-(2-(N-methylpyrrolidinyl))pyridine(54-11-5)
EPA Substance Registry System: Pyridine, 3-[(2S)-1-methyl-2-pyrrolidinyl]- (54-11-5)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : T+,N,Xn,F,Xi,T
Risk Statements : 25-27-51/53-36-20/21/22-11-36/37/38-39/23/24/25-23/24/25-59-48/20-40-36/38-24-20/22-63
Safety Statements : 7-16-36/37-45-61-36-26-37/39-59
RIDADR : UN 1654 6.1/PG 2
WGK Germany : 3
RTECS : QS5250000
TSCA : Yes
HazardClass : 6.1
PackingGroup : II
Hazardous Substances Data: 54-11-5(Hazardous Substances Data)
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P262 Do not get in eyes, on skin, or on clothing.
P321 Specific treatment (see … on this label).
P405 Store locked up.

L-Nicotine Chemical Properties,Usage,Production

Nicotine is the substance in tobacco, nicotine content of tobacco because there are different species and origin, alkali content of tobacco each part is different. Cigarette factory scraps (tobacco powder) containing about 1% to 2% of the nicotine, tobacco stems and ribs smoke nicotine containing about 1% or so, people smoked cigarette contains nicotine amounted to about 3%. Pure nicotine is a colorless, oily liquid, miscible with water below 60 ℃, hydrate, more than 210 ℃ also miscible with water. Unstable nature, likely to be volatile, soluble in water and organic solvents. Nicotine is an alkaloid, so all properties of a base, to a compound made of salts and acids. In case of light and air turn brown and sticky, there is the odd smell and strong irritant.
Pure nicotine for people, livestock highly toxic rat oral LD50 of 50~60mg/kg, rabbit acute percutaneous LD5050mg/kg. Rabbit acute percutaneous LD50 for 50~60mg/kg, rabbit acute oral LD50 of 50mg/kg. Based on China's pesticide toxicity grading standards, is a highly toxic pesticides. However, because of volatile and rapidly decompose in air and light, and therefore can still be used to control pests on crops. Rapidly absorbed through the skin, inhalation and dermal exposure to toxic people. Toxic to birds. Young steelhead LC504mg/L, toxic to bees, but there insecticide effect. D. Pulex LC50 of 0.24mg/L. Fish and shellfish toxicity, mild injury to crops.
Chemical Properties
Yellow Liquid
Naturally-occuring isomer
Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
(S)-(-)-Nicotine is a prototype nicotinic acetylcholine receptor agonist. (S)-(-)-Nicotine is the naturally occurring isomer. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.
ChEBI: An optically active form of nicotine having S-configuration.
General Description
Liquids. Toxic by inhalation, ingestion, and skin absorption. More dense than water. Flash points usually below 140°F. Contact may irritate skin, eyes, and mucous membranes. If available, obtain the technical name of the material from the shipping papers and contact CHEMTREC, (800-424-9300) for specific response information.
Air & Water Reactions
Flammable. Slightly soluble in water.
Reactivity Profile
An alkaloid produced from tobacco. Colorless, oily liquid, combustible, highly toxic. When heated to decomposition L-Nicotine emits very toxic fumes of carbon monoxide and oxides of nitrogen [Lewis, 3rd ed., 1993, p. 919].
Health Hazard
L-Nicotine is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lbs.) person. It may be assumed that ingestion of 40-60 mg of nicotine is lethal to humans. There is fundamental difference between acute toxicity from use of nicotine as insecticide or from ingestion, and chronic toxicity that may be caused by prolonged exposure to small doses as occurs in smoking. Maternal smoking during pregnancy is associated with increased risk of spontaneous abortion, low birth weight and still-birth. Nicotine was found as a co-carcinogen in animals.
Fire Hazard
There is a moderate explosion hazard when exposed to heat or flame. When heated to decomposition, L-Nicotine emits nitrogen oxides, carbon monoxide and other highly toxic fumes. Avoid oxidizing materials. Stable under normal conditions. Avoid heat or flames.
L-Nicotine Preparation Products And Raw materials
Raw materials
Preparation Products
Nicotinic acid
L-Nicotine Suppliers      Global( 180)Suppliers     
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Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 CHINA 3230 55
Hubei Heno Biological Engineering Co.,Ltd 0755-23211157 18565668426
0718-8222016 China 5 58
Hangzhou J&H Chemical Co., Ltd. +86-0571-87396432 87396430
+86-0571-87396431 China 14071 53
Wuhan Landed Scientific Ltd. 027-88739577 18163556322
027-88739578 China 61 55
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 China 15950 69
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 China 30314 84
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078,021-50426030
86-021-50426522,50426273 China 10094 60
Jia Xing Isenchem Co.,Ltd 0573-85280080,15157346371
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54-11-5(L-Nicotine)Related Search:
NA 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN SNICOTINEN1OXIDE NICOTINE, L-, [N-METHYL-3H] (-)-COTININE (3S,5S)-3'-Hydroxycotinine (2'S)-Nicotine 1-Oxide (1'R, 2'S)-Nicotine 1,1'-Di-N-Oxide [20% in ethanol] NICOTINE, D [N-METHYL 14C] (S)-1-METHYLNICOTINIUM IODIDE Nicotinic acid Kresoxim-methyl Methylparaben Parathion-methyl Bensulfuron methyl Thiophanate-methyl Tetrahydro pyrrole Pyridine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine (-)-3-(N-Methylpyrrolidino)pyridine (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine 1-methyl-2-(3-pyridal)-pyrrolidin 1-Methyl-2-(3-pyridiyl)pyrrolidine 3-(1-Methyl-2-pyrollidinyl)pyridine 3-(1-Methyl-2-pyrrolidinyl) 3-(1-methyl-2-pyrrolidinyl)-,(S)-Pyridine 3-(1-methyl-2-pyrrolidyl)pyridine 3-(N-Methylpyrollidino)pyridine 3-(n-methylpyrrolidino)pyridine beta-Pyridyl-alpha-N-methylpyrrolidine Black Leaf blackleaf Campbell's nico-soap caswellno597 Destruxol orchid spray destruxolorchidspray dl-tetrahydronicotyrin Emo-Nik ent3,424 Flux Maag fluxmaag Fumetobac L-3-(1-Methyl-2-pyrrolidyl)pyridine Mach-Nic Niagara p.a. dust niagarap.a.dust Nicocide Nico-Dust Nico-Fume Nicotina Nicotine alkaloid nicotine(presentasalkaloidorassulphate) nicotine,[liquid] nicotinealkaloid nicotineandsalts Nic-Sal Nikotyna nikotyna(polish) Ortho N-4 and N-5 dusts Ortho N-4 dust Ortho N-5 dust orthon-4andn-5dusts orthon-4dust orthon-5dust Pyridine, 3-(1-methyl-2-pyrrolidinyl)- Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)- Pyridine, 3-(tetrahydro-1-methylpyrrol-2-yl) Pyridine,3-(1-methyl-2-pyrrolidinyl)-,(S)- pyridine,3-(tetrahydro-1-methylpyrrol-2-yl) Pyrrolidine, 1-methyl-2-(3-pyridyl)- rcrawastenumberp075 Tendust Tetrahydronicotyrine, DL- XL All Insecticide xlallinsecticide Pyridine Alkaloids
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