Lacidipine | 103890-78-4

Lacidipine Properties

Melting point	174-175°C
Boiling point	558.4±50.0 °C(Predicted)
Density	1.127±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: soluble20mg/mL, clear
pka	3.00±0.70(Predicted)
form	powder
color	white to beige
Merck	14,5331
InChIKey	GKQPCPXONLDCMU-CCEZHUSRSA-N
CAS DataBase Reference	103890-78-4(CAS DataBase Reference)
FDA UNII	260080034N
ATC code	C08CA09

Pharmacokinetic data

Protein binding	95%
Volume of distribution	0.9-2.3(L/kg)
Biological half-life	13-19 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312+P330-P501

Hazard Codes

Xn

Risk Statements

22

WGK Germany

3

RTECS

US7970200

Toxicity

mouse,LD50,intraperitoneal,80200ug/kg (80.2mg/kg),SKIN AND APPENDAGES (SKIN): HAIR: OTHERSENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.

NFPA 704

	0
1		0

Lacidipine price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0946	Lacidipine ≥98% (HPLC)	103890-78-4	10mg	$88.8	2024-03-01	Buy
Sigma-Aldrich	SML0946	Lacidipine ≥98% (HPLC)	103890-78-4	50mg	$286	2024-03-01	Buy
TCI Chemical	L0276	Lacidipine >98.0%(HPLC)(N)	103890-78-4	1g	$480	2023-01-07	Buy
TCI Chemical	L0276	Lacidipine >98.0%(HPLC)(N)	103890-78-4	200mg	$146	2021-12-16	Buy
Cayman Chemical	28270	Lacidipine	103890-78-4	100mg	$97	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0946	10mg	$88.8	Buy
SML0946	50mg	$286	Buy
L0276	1g	$480	Buy
L0276	200mg	$146	Buy
28270	100mg	$97	Buy

Lacidipine Chemical Properties,Uses,Production

Description

Lacidipine is a new second-generation dihydropyridine calcium antagonist introduced as a once a day treatment for mild to moderate hypertension. It is reported to have high selectivity for vascular smooth muscle and also a long duration of action. The use of lacidipine as an antiatherosclerotic agent is currently under investigation.

Description

Lacidipine is a dihydropyridine L-type calcium channel blocker. It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA₂ = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC₅₀s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC₅₀ = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED₂₅ = 0.35 mg/kg) and in renal hypertensive dogs (ED₂₅ = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 μM. It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE^-/- mice in a model of Western diet-induced atherosclerosis.

Chemical Properties

White-to-Off-White Crystalline Solid

Originator

Glaxo (United Kingdom)

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Uses

antihypertensive;dihydropyridinr calcium channel blocker

Definition

ChEBI: Lacidipine is a cinnamate ester and a tert-butyl ester.

brand name

Lacipil; Lacirex; Viapres

Biochem/physiol Actions

Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension. Lacidipine is a L-type Ca(2+) channel blocker belonging to 1,4-dihydropyridine class. Also, Lacidipine inhibits ryanodine receptors on the ER membrane that enhances folding, trafficking and lysosomal activity of ERAD (ER-associated degradation) misfolded lysosomal glucocerebrosidase (GS).

Lacidipine synthesis

Synthesis of Lacidipine from (tert-Butoxycarbonylmethyl)triphenylphosphanium bromide and ETHYL 3-AMINOCROTONATE and o-Phthalaldehyde

Lacidipine Preparation Products And Raw materials

Raw materials

tert-Butyl acetate Ethyl crotonate o-Phthalaldehyde trans-Cinnamic acid Triphenylphosphine

tert-Butyl acrylate

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Preparation Products

Lacidipine Suppliers

Global( 352)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hubei XinRunde Chemical Co., Ltd.	+8615102730682	bruce@xrdchem.cn	CHINA	566	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12453	58

Supplier	Advantage
Henan Bao Enluo International TradeCo.，LTD	58
Henan Tianfu Chemical Co.,Ltd.	55
Hubei XinRunde Chemical Co., Ltd.	55
career henan chemical co	58
Shandong chuangyingchemical Co., Ltd.	58
BOC Sciences	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hebei Mojin Biotechnology Co., Ltd	58

View Lastest Price from Lacidipine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-08-10	Lacidipine 103890-78-4	US $120.00 / kg	1kg	99%	1000tons	Henan Bao Enluo International TradeCo.，LTD
2023-02-09	Lacidipine 103890-78-4	US $0.00 / G	10G	98%min	30kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2023-01-31	Lacidipine 103890-78-4	US $100.00 / KG	1KG	99%	5000kg/week	Hebei Mojin Biotechnology Co., Ltd

Lacidipine
103890-78-4
US $120.00 / kg
99%
Henan Bao Enluo International TradeCo.，LTD

Lacidipine
103890-78-4
US $0.00 / G
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Lacidipine
103890-78-4
US $100.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

Lacidipine Spectrum

Lacidipine(103890-78-4)¹HNMR

103890-78-4(Lacidipine)Related Search:

Phenyl salicylate Ethoxyquin DIETHOXYMETHANE Diphenyl ether PHENYL VALERATE

Fentin hydroxide Ethoxyamine hydrochloride PHENYL RESIN Phenylacetic acid Oxygen

cis Lacidipine trans Lacidipine-d10,LACIDIPINE-D10 Dehydro Lacidipine 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID Lacidipine

LACIDIPINE INTERMEDIATE:4-(2-BROMOPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 4-(2-bromophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester (intermediate of lacidipine) LACIDIPINE IMPURITY STANDARD

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3,5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-(3-(1,1-dimethylet diethylester,(e)-hoxy)-3-oxo-1-propenyl)phenyl) MOTENS 3,5-Diethyl 4-{2-[(1E)-3-(tert-butoxy)-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate CID 5311217 Lacidipine，Lacipil 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-diethyl ester GX-1048,GR-43659X,SN-305 LACIPIL LACIREX LACIDIPINE LACIDIPINE-D9 Lacidipin LACIDIPINE, IMPURITY STANDARD BP STANDARD LACIDIPINE, BP STANDARD LACIDIPINE ASSAY STANDARD BP(CRM STANDARD) LACIDIPINE BP STANDARD(CRM STANDARD) LACIDIPINE IMPURITY STANDARD BP STANDARD(CRM STANDARD) LACIDIPINE IMPURITY STANDARD BP(CRM STANDARD) LacidipineC26H33N06 GX-1048 GR-43659X CALDINE (E)-4-[2-[3-(1,1-DIMETHYLETHOXY)-3-OXO-1-PROPENYL]PHENYL]-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER (E)-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester, GR-43659X, GX-1048, Caldine, Lacipil, Lacirex, Motens trans Lacidipine Lacidipine (Lacipil, Motens) 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1- propenyl)phenyl)-, diethyl ester, (E)- Diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate 4-[2-[(1E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester 4-[2-[(E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester SN-305 Lacidipine Solution, 100ppm Lacidipine Solution, 1000ppm LACIPIL;MOTENS 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester 3,5-Pyridinedicarboxylic acid, 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester Lacidipine USP/EP/BP (E)-Diethyl 4-(2-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Lacidipine (GX-1048, GR-43659X, SN-305, Lacipil, Motens) LacidipineQ: What is Lacidipine Q: What is the CAS Number of Lacidipine Q: What is the storage condition of Lacidipine Q: What are the applications of Lacidipine β-GPA Lacidipine flat Lacipil, Motens, Lacidipine iethyl2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate Lacidipine Diethyl 4-{o-[(E)-2-tert-butoxycarbonylethenyl]phenyl}-2,6- dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 103890-78-4 C26H33NO6 C26H24NO6D9 Calcium channel Dihydropyridine Intermediates & Fine Chemicals Pharmaceuticals Active Pharmaceutical Ingredients Dihydropyridine Class Chemicals API Lacipil, Motens