Kasugamycin hydrochloride
- CAS No.
- 19408-46-9
- Chemical Name:
- Kasugamycin hydrochloride
- Synonyms
- kasumin;Kasugamycin hy;KasugaMycin HCl;kasugamycin (jmaff);KASUGAMYCIN HYDROCHL;KASUGAMYCIN HCL HYDRATE;KASUGAMYCIN HYDROCHLORIDE;Kasugamycin HCl, Monohydrate;kasugamycin,monohydrochloride;KASUGAMYCIN HYDROCHLORIDE HYDRATE
- CBNumber:
- CB5297221
- Molecular Formula:
- C14H25N3O9.ClH
- Molecular Weight:
- 415.82
- MDL Number:
- MFCD00058459
- MOL File:
- 19408-46-9.mol
- MSDS File:
- SDS
| Melting point | 202-204 °C (decomp) |
|---|---|
| vapor pressure | <1.3x l0-8 Pa (25 °C) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | H2O: soluble |
| pka | 3.23 (carboxyl), 7.73 and 11.0 (bases) |
| Water Solubility | 125 g l-1 (25 °C) |
| color | white to off-white |
| Stability | Hygroscopic |
| CAS DataBase Reference | 19408-46-9(CAS DataBase Reference) |
| FDA UNII | SXA18D440T |
| EPA Substance Registry System | Kasugamycin monohydrochloride (19408-46-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| Safety Statements | 22-24/25-26 |
| WGK Germany | 2 |
| RTECS | NM7521800 |
Kasugamycin hydrochloride price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | K4013 | Kasugamycin hydrochloride from Streptomyces kasugaensis ≥90% (HPLC) | 19408-46-9 | 10g | $402 | 2024-03-01 | Buy |
| Sigma-Aldrich | 32354 | Kasugamycin hydrochloride VETRANAL | 19408-46-9 | 100mg | $69.5 | 2024-03-01 | Buy |
| Alfa Aesar | J67325 | Kasugamycin, 50 mg/ml in distilled water, sterile-filtered | 19408-46-9 | 25ml | $294 | 2023-06-20 | Buy |
| Alfa Aesar | J67325 | Kasugamycin, 50 mg/ml in distilled water, sterile-filtered | 19408-46-9 | 50ml | $340 | 2021-12-16 | Buy |
| Cayman Chemical | 15322 | Kasugamycin (hydrochloride) ≥70% | 19408-46-9 | 1g | $48 | 2023-06-20 | Buy |
Kasugamycin hydrochloride Chemical Properties,Uses,Production
Description
Kasugamycin is an aminoglycosidic antibiotic isolated from S. kasugaensis. It blocks the initiation of translation, preventing initiation complex formation on 30S ribosomes in bacteria.
Uses
kasugamycin, derived from Streptomyces kasuguensis, is also used to control rice blast.It acts by inhibiting protein synthesis by interfering with the binding of aminoacyl-tRNA to the mRNA-30s ribosomal subunit complex (Yamaguchi, 1998).
Uses
antifungal
Uses
Kasugamycin Hydrochloride is an aminoglycoside antibiotic that inhibits the initiation of translation. It is also a type of fungicide that controls leaf and neck blast disease caused by Pyricularia oryzae and increases rice yields.
in vitro
kasugamycin could inhibit protein synthesis by interacting with the 30s ribosomal subunit. the mechanism of inhibition of protein synthesis appeared to be different from that of other aminoglycosides, such as kanamycin, streptomycin, neomycin, gentamicin. the initiation complex formation on 30s ribosomes could be inhibited by kasugamycin but not by streptomycin, kanamycin or gentamicin, though the binding of fmet-trna to 70s ribosomes was inhibited by both streptomycin and by kasugamycin. [1].
in vivo
five groups, each consisting of five guinea pigs, were infected with shibaura strain; two groups were treated by injection with kasugamycin. all animals treated with 1 mcg/g were killed showing an average survival period of 7.4 days, which was close to the average survival period of 6.2 days in the control group; while all animals treated with 5 mcg/g survived. the other two groups were treated with kasugamycin from the icteric stage to the 10th day after infection. two animals of the 5 mcg/g group survived, showing no leptospira in the kidney; the other three died in an average of 7.7 days. three animals of the 10 mcg/g group survived; while the other two animals died in 6.5 days on an average . the total amounts of kasugamycin administered to the infected guinea pigs from the febrile stage were 10.8 mg (the 1 mcg/g group) and 54.0 mg (the 5 mcg/g group) [2].
Metabolic pathway
kasugamycin hydrochloride hydrate is a relatively stable antibiotic. There is limited published information on its metabolism and environmental fate but it is extensively degraded in plants and soil as indicated in Scheme 1.
Degradation
kasugamycin hydrochloride hydrate is very stable at room temperature. It is stable in weak acids but unstable in strong acids and under basic conditions. Its DT50 values at 50 °C are 47 and 14 days at pH 5 and 9, respectively (PM).
References
[1] okuyama, a. ,machiyama, n.,kinoshita, t., et al. inhibition by kasugamycin of initiation complex formation on 30s ribosomes. biochemical and biophysical research communications 43(1), 196-199 (1971).
[2] kitaoka m, mori m, arimitsu y. in vitro and in vivo effects of kasugamycin on leptospira icterohaemorrhagiae. jpn j med sci biol. 1975 oct-dec;28(5-6):285-90.
Kasugamycin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 1696 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
View Lastest Price from Kasugamycin hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-18 | Kasugamycin Hydrochloride
19408-46-9
|
US $1.00 / KG | 1KG | 99.91% | 200000 | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-12-12 | Kasugamycin hydrochloride
19408-46-9
|
US $3.20 / Kg/Drum | 1KG | 99% | 20tons per month | qingdao trust agri chemical co.,ltd | |
 |
2023-09-15 | Kasugamycin hydrochloride
19408-46-9
|
US $10.00-1.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Kasugamycin Hydrochloride
19408-46-9
- US $1.00 / KG
- 99.91%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Kasugamycin hydrochloride
19408-46-9
- US $3.20 / Kg/Drum
- 99%
- qingdao trust agri chemical co.,ltd
-
- Kasugamycin hydrochloride
19408-46-9
- US $10.00-1.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.