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2-N-HEXYL-4-PENTYNOIC ACID

CAS No.
96017-59-3
Chemical Name:
2-N-HEXYL-4-PENTYNOIC ACID
Synonyms
Hexyl-4-pentynoic Acid;2-Hexyl-4-pentynoic Acid;2-PROPARGYLOCTANOIC ACID;2-Hexyl-4-pentynoicAcid>2-N-HEXYL-4-PENTYNOIC ACID;2-(2-PROPYNYL)OCTANOIC ACID;Hexyl-4-pentynoic acid (HPA);R-2-(2-propynyl)octanoic acid;2-(2-Propyn-1-yl)octanoic Acid;2-(Prop-2-yn-1-yl)octanoic acid
CBNumber:
CB5317246
Molecular Formula:
C11H18O2
Molecular Weight:
182.26
MDL Number:
MFCD00946863
MOL File:
96017-59-3.mol
MSDS File:
SDS
Last updated:2023-06-08 17:06:35

2-N-HEXYL-4-PENTYNOIC ACID Properties

Boiling point 287.1±23.0 °C(Predicted)
Density 0.94
refractive index 1.4450-1.4510
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form oil
pka 4.24±0.21(Predicted)
color Colorless
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xn
Risk Statements  22
HS Code  2916.19.3000
NFPA 704
0
2 0

2-N-HEXYL-4-PENTYNOIC ACID price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical H0964 2-Hexyl-4-pentynoic Acid >95.0%(T) 96017-59-3 5g $239 2024-03-01 Buy
TCI Chemical H0964 2-Hexyl-4-pentynoic Acid >95.0%(T) 96017-59-3 25g $762 2024-03-01 Buy
Cayman Chemical 15205 2-hexyl-4-Pentynoic Acid ≥95% 96017-59-3 1g $120 2024-03-01 Buy
Cayman Chemical 15205 2-hexyl-4-Pentynoic Acid ≥95% 96017-59-3 5g $257 2024-03-01 Buy
Cayman Chemical 15205 2-hexyl-4-Pentynoic Acid ≥95% 96017-59-3 250mg $44 2024-03-01 Buy
Product number Packaging Price Buy
H0964 5g $239 Buy
H0964 25g $762 Buy
15205 1g $120 Buy
15205 5g $257 Buy
15205 250mg $44 Buy

2-N-HEXYL-4-PENTYNOIC ACID Chemical Properties,Uses,Production

Description

2-hexyl-4-Pentynoic acid is a derivative of valproic acid , an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 μM. It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 μM.

References

1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272 2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127

2-N-HEXYL-4-PENTYNOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

2-N-HEXYL-4-PENTYNOIC ACID Suppliers

Global( 52)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
Aladdin Scientific
+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131981 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006608290; 18621169109 market03@meryer.com China 40241 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24539 81
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18739 57
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66099280 17798518460 cfzhang@aikonchem.com China 19918 55

2-N-HEXYL-4-PENTYNOIC ACID Spectrum

2-(2-PROPYNYL)OCTANOIC ACID 2-N-HEXYL-4-PENTYNOIC ACID 2-PROPARGYLOCTANOIC ACID 2-Hexyl-4-pentynoic Acid 2-Propargyloctanoic Acid 2-(2-Propynyl)octanoic Acid 2-Hexyl-4-pentynoicAcid> 2-(Prop-2-yn-1-yl)octanoic acid Hexyl-4-pentynoic acid (HPA) R-2-(2-propynyl)octanoic acid Hexyl-4-pentynoic Acid HDAC inhibitor,Heat shock proteins,HSP70,Excitotoxicity,Histone deacetylases,inhibit,HDAC,Neuroprotection,2hexyl4Pentynoic Acid,2 hexyl 4 Pentynoic Acid,Inhibitor,Glutamate,HSP,Valproic acid Octanoic acid, 2-(2-propyn-1-yl)- 2-(2-Propyn-1-yl)octanoic Acid 96017-59-3 Acetylenic Carboxylic Acids & Their Derivatives Acetylenes Acetylenic Carboxylic Acids & Their Derivatives Acetylenes