ChemicalBook >> CAS DataBase List >>3-Nitrophthalic acid
3-Nitrophthalic acid
- CAS No.
- 603-11-2
- Chemical Name:
- 3-Nitrophthalic acid
- Synonyms
- 3-NPA;o-Nitrophthalic acid;Pomalidomide Impurity 8;3-nitro-1,2-benzenedicarboxylic acid;NSC 3120;AKOS B028734;3-nitrophthalic;3-nitro-phthalate;RARECHEM AL BO 0803;m-Nitrophthalic acid
- CBNumber:
- CB5323089
- Molecular Formula:
- C8H5NO6
- Molecular Weight:
- 211.13
- MDL Number:
- MFCD00007138
- MOL File:
- 603-11-2.mol
- MSDS File:
- SDS
Last updated:2024-03-28 17:11:29
| Melting point | 210 °C (dec.) (lit.) |
|---|---|
| Boiling point | 350.79°C (rough estimate) |
| Density | 1.6342 (rough estimate) |
| vapor density | 7.3 (vs air) |
| refractive index | 1.5282 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | water: soluble5%, clear to slightly hazy, colorless to faint yellow or tan |
| form | Powder |
| pka | pK1:1.88 (25°C) |
| color | Off-white to light yellow |
| Water Solubility | 20 g/L (25 ºC) |
| Decomposition | 216 °C |
| BRN | 2054269 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | KFIRODWJCYBBHY-UHFFFAOYSA-N |
| CAS DataBase Reference | 603-11-2(CAS DataBase Reference) |
| FDA UNII | MC7W4GB97C |
| NIST Chemistry Reference | 3-Nitrophthalic acid(603-11-2) |
| EPA Substance Registry System | 3-Nitrophthalic acid (603-11-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-41 | |||||||||
| Safety Statements | 26-36/39-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29173980 | |||||||||
| NFPA 704 |
|
3-Nitrophthalic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 369306 | 3-Nitrophthalic acid 95% | 603-11-2 | 100g | $59.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 137820 | 3-Nitrophthalic acid 99% | 603-11-2 | 100g | $145 | 2024-03-01 | Buy |
| TCI Chemical | N0243 | 3-Nitrophthalic Acid >98.0%(HPLC)(T) | 603-11-2 | 25g | $31 | 2024-03-01 | Buy |
| TCI Chemical | N0243 | 3-Nitrophthalic Acid >98.0%(HPLC)(T) | 603-11-2 | 500g | $140 | 2024-03-01 | Buy |
| Alfa Aesar | A14281 | 3-Nitrophthalic acid, 95% | 603-11-2 | 100g | $48.65 | 2024-03-01 | Buy |
3-Nitrophthalic acid Chemical Properties,Uses,Production
Chemical Properties
Pale yellow crystals. soluble in hot water, methanol, ethanol, slightly soluble in ether, insoluble in chloroform, carbon tetrachloride, carbon disulfide, benzene.
Uses
3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast.
Uses
3-Nitrophthalic acid may be used as starting reagent in the synthesis of modified 2-iodoxybenzoic acid derivatives. It may be used in the synthesis of brucinium 2-carboxy-6-nitrophthalate dihydrate (systematic name: 2,3-dimethoxy-10-oxostrychnidinium 2-carboxy-6-nitrophthalate dihydrate), via heating with brucine.
Preparation
Phthalic anhydride was added to concentrated sulfuric acid, stirring under the passage of water vapor heating to 80 °C, fuming nitric acid was added dropwise, the reaction temperature to maintain 100-110°C, add the end of the heat above 110°C for 2h, placed in the overnight pour into the water, and filtered. The filter cake was recrystallized with water to obtain 3-Nitrophthalic acid. Yield of about 30%.
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 2468, 1974 DOI: 10.1021/jo00930a051
General Description
3-Nitrophthalic acid is a degradation product of isoxaben herbicide. It acts as ligand and forms rare-earth complexes.
Safety Profile
A preparative hazard. When heated to decomposition it emits toxic fumes of NOx.
Purification Methods
Crystallise 3-nitrophthalic acid from hot water (1.5mL/g). Dry it in air. The amide has m 201o (from EtOH). [Beilstein 9 H 823, 9 IV 3275.]
3-Nitrophthalic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Candesartan
Luminol
2-Amino-6-nitrobenzoic acid
3-Nitrophthalic anhydride
3-CHLOROPHTHALIC ANHYDRIDE
1of3
Global( 684)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Asia Chem I and E (Jiangsu) Co Ltd | +8615105181882 | mera.z@nitrobenzenechemical.com | China | 129 | 58 |
| shandong exelon biochem co.ld | +86-533-2119995 +8615053330977 | 451614802@QQ.com | China | 28 | 58 |
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7378 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Yancheng Green Chemicals Co.,Ltd | +undefined-86-25-86655873 | info@royal-chem.com | China | 114 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from 3-Nitrophthalic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-18 | 3-Nitrophthalic acid
603-11-2
|
US $12.56 / Kg/Drum | 25Kg/Drum | 99.5%HPLC | 20tons/month | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2024-03-29 | 3-nitrophthalic acid
603-11-2
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | |
 |
2023-12-26 | 3-Nitrophthalic acid
603-11-2
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- 3-Nitrophthalic acid
603-11-2
- US $12.56 / Kg/Drum
- 99.5%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 3-nitrophthalic acid
603-11-2
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- 3-Nitrophthalic acid
603-11-2
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
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603-11-2
603-111-2
603-11-8
603-11-3
O2NC6H3COOH2
C8H5NO6
C8H5O6N
O2NC6H312CO2H2
Organic Building Blocks
Building Blocks
C8
Carboxylic Acids
Carbonyl Compounds
intermediate
Aromatics
C8
Carbonyl Compounds
Carboxylic Acids
Organic acids
Dyes intermediates
Phthalic Acids, Esters and Derivatives
Organics
1
603-11-2